Musalin halittar halittar jini huhu

Fahimtar rawar Musalin halittar halittar jini huhu yana da mahimmanci ga keɓaɓɓen sarrafa cutar kansa. Wannan labarin yana binciken yadda gwajin kwayoyin halitta ke ba da sanarwar yanke hukunci na jikoki, da magungunan da suka shafi cutar sankarar mahaifa a duniya, galibi ana tura su ta hanyar Musalin halittar halittar jini huhu. Waɗannan maye gurbi na iya faruwa a cikin kwayoyin da ke sarrafawa sel, rarrabuwa, da gyara. Gano irin maye gurbi yana da mahimmanci saboda yana iya jagorantar dabarun magani da inganta sakamako mai haƙuri. A at Shandong Cibiyar Bincike ta Bincike Cibiyar Shaidar, muna fifita fahimtar yanayin kwayoyin halittar kowane kerewararrun kasar.Musalin halittar halittar jini huhu canji ne a cikin jerin DNA wanda zai iya haifar da halayen sel sel. Wadannan maye gurbi za a iya gādon ko samu a rayuwar mutum. A cikin ciwon daji na huhu, wanda ya samu maye gurbinsu mafi gama gari kuma galibi ana haifar da abubuwan da muhalli ko fuskantar shan sigari. Wadannan maye gurbi na iya rushe hanyoyin samar da salula na yau da kullun, haifar da haɓakar haɓakawa da kuma samuwar ciwace-ciwacen daji a cikin ciwon daji na huhu. Fahimtar wadannan maye gurbi yana da mahimmanci don zabar tsarin jiyya ta dama. Ga wasu daga cikin abubuwan da suka fi kowa:Egfr (epidmal ci gaban da ke tattare da shi): Yesu ya zama ruwan dare gama gari a cikin ƙarancin ƙwayar sel mara ƙarfi (NSCLC), musamman a Adenocarcinomas. Waɗannan maye gurbi na iya haifar da sel na ciwon daji fiye da wasu magungunan da aka yi niyya.AlK (Anagrasic Lymphoma Kinase): Alk Abitrangements wani maye gurbi ne wanda aka samo a cikin NSCLC. Masu hana mu sun hana samun nasara wajen magance ciwan da ke da wannan maye gurbi.ROS1: Kama da AlK, Ros1 Fusions na iya fitar da haɓakar cutar sankarar mahaifa. Akwai masu hana kishin ROS1 don marasa lafiya da ROSP-tabbatacce NSCLC.Braf: Canjin Braf, musamman maye gurbi ne a cikin NSCLC. Za'a iya amfani da masu hana kibau don yin niyya ga waɗannan maye gurbi.Kras: Kras maye gurbi ne na gama gari a cikin huhu adencaroma krun. Yayin da tarihi yayi wuya a ci gaba, da sababbin magungunan suna fitowa don kula da Krats na cutar sankara.PD-L1 (an shirya shi-Ligand 1): Duk da yake ba a maye gurbi a cikin gargajiya na gargajiya, PD-L1 nuna magana ne da ke bita wanda zai iya yin hukunci da martani ga rigakafin rigakafi. Babban magana Pd-L1 na iya nuna cewa mai haƙuri ya fi amfanar da gwajin Imnunothera don ciwon kansaMusalin halittar halittar jini huhu An gano ta hanyar cikakkiyar gwajin halittar halitta, wanda kuma aka sani da gwajin biomarer ko mai amfani da kwayar cutar. Wannan nazarin tarin girki nama ko, a wasu halaye, samfuran jini don gano takamaiman canji na kwayoyin da ke tuki haɓaka cutar kansa da ke tuki ci gaban cutar kansa. Sakamakon waɗannan gwaje-gwajen suna taimakawa wajen tsara shirye-shiryen da ke shirin magani don yin niyya ga halaye na musamman na cutar kansa kowane mai haƙuri. Cibiyar Shaidar Cibiyar Cutar Cutar Cibiyar Cutar tana amfani da fasahar gwajin-art-dabaru.typespes na shaidar cututtukan kwayoyin halitta da kuma tsarin maganin cutar sankarar mahaifa:Search tsara (NSG): NGS shine cikakkiyar hanyar gwaji wanda zai iya bincika halittar halittu da yawa a lokaci guda. Wannan yana ba da damar gano ƙarin maye gurbi da sauran gyare-gyare da yawa.Polymormes sarkar dauki (PCR): PCR ne mafi mai da hankali ga hanyar gwaji wanda ake amfani dashi don gano takamaiman maye gurbi ko kayan aikin.CLEILESFESFE A TUEU Hybridization (kifi): Ana amfani da kifi don gano kayan aikin, kamar AlK da Ros1 Fusions.Imnunohistahoferview:: IHC): Ana amfani da IHC don gano kalmomin furotin, kamar Pd-l1, wanda zai iya taimakawa wajen yin hasashen rigakafin rigakafi a kan duk marasa lafiya da aka kamu da cutar NSCLC. Ya kamata a yi gwaji a farkon abin da zai yiwu a tsarin shirya magani wanda ya kamata a yi la'akari da magudin da aka yi niyya daga farkon. Hakanan yana da mahimmanci don sake gwadawa idan ciwon daji ya samu.Rarfafa Sifikar da aka yiwa magungunan ciwon jiki da musamman kan ƙwayoyin cutar sankara musamman Musalin halittar halittar jini huhu. Wadannan hanyoyin kwantar da hankali an tsara su don tsoma baki, rarrabuwa, kuma yaduwar sel na cutar kansa yayin rage lalacewar sel na yau da kullun. Asibitin Asibitin Baoa na yau da kullun yana amfani da mafi yawan ci gaba da aka niyya.egfr Ingfitorygfr ana amfani da su don kula da cutar sankara da cutar sankara. Wadannan kwayoyi suna toshe ayyukan furotin na EGFR, wanda yawanci ana watsi da sel ne a sel na ciwon daji tare da waɗannan maye gurbi. Abubuwan da ke haifar da kayan kwalliya na yau da kullun sun haɗa da:Gefitinib (iresssa)Erlotinib (taraceva)Afatinib (Gilotrif)Osimertinib (Tagristo): Sau da yawa magani na farko don maganin egfr-mutated NSCLC.k Inhibitoral masu hana cutar da cutar sankara da alkama. Wadannan kwayoyi suna toshe ayyukan furotin na AlK, wanda yawanci yana aiki ne a cikin sel na cutar kansa tare da waɗannan abubuwan. Abubuwan da aka keɓe na AlK sun haɗa da:Crizotinib (xalkori)Apinib (Alecelna)CeriITinib (Zykadia)Brigatinb (Alunrbig)Lorlatinib (Lorbrebena)Ros1 inhibitorsross1 ana ba da izini don kula da cututtukan huhu tare da ROS1 Fusions. Wadannan kwayoyi suna toshe ayyukan furotin na ROS1, wanda yawanci yana aiki cikin sel na cutar kansa tare da waɗannan fusions. Ros1 na gama gari sun hada da:Crizotinib (xalkori)Entcterib (rozlytrek)BRAF Inhiitorraf masu hana cutar suna amfani da cutar sankarar mahaifa da maye gurbi, musamman maye gurbi. Wadannan kwayoyi suna toshe ayyukan furotin na BRA, wanda yawanci ana fitar da su ne a cikin sel na ciwon daji tare da waɗannan maye gurbi. Abubuwan da ke hana su na yau da kullun sun hada da:Dabrafib (Tafinllar)Trartib (Minkinist): Sau da yawa ana amfani dashi a hade tare da Dabrafeib.kras infiborsotorasibasib (lumakras) da ADagrasib (Kraikras) da ADagrasib (kraakras) da masu cutar sankarar Krung da aka yi amfani da su don magance cutar hats. Suna aiki ta hanyar toshe ayyukan Kras Presarin gina jiki na Muteotheics da kwayoyin halittar asalinsu wani nau'in cutar kansa ne ta fi gaban cutar kansa. Yayin da rigakafin ya zama manufa kai tsaye Musalin halittar halittar jini huhu, Anali da wasu maye gurbi da biomarkers, kamar bayyana PD-L1 da kuma tsinkaye na ƙwayar cuta (TMB), na iya yin hasashen amsa ga ƙwaƙwalwar ajiya. Marasa lafiya tare da bayyanar PD-L1 ko babban TMB na iya amfana da rashin rigakafin rigakafi. A Kananin Bincike na Shandong Cibiyar Cutar Cibiyar Bincike ta Shander, za mu inganta maganin rigakafi tare da wasu hanyoyin kulawa don cikakken maganin cututtukan daji na cutar sankarar mahaifa. Ana ci gaba da sabbin kwastomomin da aka yi niyya kuma ana gwada su a cikin gwaje-gwaje na asibiti. Masu bincike suna kuma yin aiki don gano sabon Musalin halittar halittar jini huhu ana iya yin niyya tare da magungunan malami. A matsayin fahimtarmu game da ilimin cutar sankarar mahaifa, muna iya tsammanin ganin zaɓuɓɓukan magani da inganci ga marasa lafiya. Cibiyar Bincike ta Shandong Cibleer Cener ta himmatu wajen kasancewa a kan wadannan cigaban tebur Lorlatinibblock Alkerein Motros1Crizotinib, entedabrasib, sau da yawa tare da Track Musalin halittar halittar jini huhu yana da mahimmanci don inganta sakamako ga marasa lafiya da cutar sankara. Gwajin halittar halittar na iya taimakawa gano takamaiman maye gurbi wanda za'a iya kaiwa tare da kwayar halittu. Kamar yadda fahimtarmu game da ilimin cutar sankarar mahaifa ta ci gaba, muna iya tsammanin ganin mafi inganci da kuma tafiyata da aka yi niyya don wannan cuta mai lalata. Ziyarta Shandong Cible Bincike Cibiyar Bincike don ƙarin koyo game da cikakken tsarinmu ga kulawar cutar kansa.Discimer: Wannan bayanin shine don dalilai na ilimi kawai kuma bai kamata a dauki shawarar likita ba. Koyaushe shawara tare da ƙwararren ƙwararren kiwon lafiya don ganewar asali da kuma lura da yanayin likita. www.cancer.govBa'amurke na kasar Sin. www.cancer.org