ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution

Ka hoʻomaopopoʻana i ka hana o ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution he mea nui no ka hoʻokele pilikino a me ka pono o ka hoʻokele Cancer Cancer. Hōʻike kēiaʻatikala i ka hōʻikeʻana o ka hōʻikeʻana i nā manaʻo e pili ana i ka maʻi maʻi maʻamau, a uaʻikeʻia nā kumu maʻi Cancerl ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution. ^. Hiki i kēia mau hoa'āina ke hele mai i nā gene e ulu ana ka uluʻana o ke kelepona,ʻokoʻa, a me ka hoʻoponopono. ʻO ka hoʻomaopopoʻana i kēia mau mutations he mea pono no ka mea hiki ke alakaʻi i nā hoʻolālā lapaʻau a hoʻomaikaʻi i nā hopena maʻi. Ma ka noiʻiʻanaʻo Shandong Banufa Cancer noiʻi noiʻi, hana mua mākou i ka hoʻomaopopoʻana i ka maʻi genetic o kēlā me kēia maʻi maʻi o kēlā me kēia maʻi maʻi?ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution e loli ana i ka hana dna e hiki ke alakaʻi i keʻano o keʻano o keʻano. Hiki i kēia mau hiʻohiʻona ke hoʻokaʻawale a loaʻa paha i ka wā o ke ola o kahi kanaka. Ma ka maʻi maʻi maʻi, loaʻa nā mutations i loaʻa i nā mea maʻamau a maʻamau pinepineʻia e nā mea kūlohelohe e like me ka ulaula a iʻole ka hoʻolahaʻana i nā haumia. Hiki i kēia mau'ōkuhi ke hōʻole i nā kaʻina hana maʻamau, ke alakaʻiʻana i ka uluʻana o ka uluʻana a me ka hoʻokumuʻana i nā'ōmole genetics genetics. ʻO ka hoʻomaopopoʻana he mea nui kēia mau mutations no ke kohoʻana i ke ala kūpono kūpono. Eia kekahi o nā mea maʻamau:Egfr (epidermal (epidermal ulu ulu gautor): ʻO nā mika i ka egfr maʻamau ma keʻano heʻelima manuahi liʻiliʻiʻole (nsclc), kūikawā ma Adenocarcinoma. Hiki i kēia mau'ōkuhi ke hana i nā cancer cell iʻoi aku ka naʻau iʻikeʻia i loko o kekahi mau mea i kohoʻia.Alk (Anuplastic Lymphoma Kinase): ʻO nā hoʻoponopono alkʻo ia kekahi mau mea kiko'ī i loaʻa i ka mika i loaʻa ma NSCLC. Ua hōʻikeʻo Alk In Mohatorst i ka kūleʻa nui ma ka mālamaʻana i nā tumors me kēia mutation.Ros1: E like me Alk,ʻo Ros1 mau fusiotion hiki ke kiʻi i ka ulu lāʻau maʻi lungu. Loaʻa nā IS1 IS1 i nā maʻi no nā maʻi me Ros1-maikaʻi NSCLC.Braf: ʻO nā'ōkuhi Braf,ʻo ia ka mutation V600E, hiki ke loaʻa ma NSCLC. Hiki ke hoʻohanaʻia nā inhibors BrafʻO Kēia: ʻO Kras MITITALS maʻamau ma LUNG ADENORCACINMA. ʻOiai paʻakikī e paʻakikī i nā pahuhopu, e kū mai nā mea hana hou e mālama pono iā Kran-mutated lingubers.PD-L1 (huiʻia i ka make-ligand 1): ʻOiaiʻaʻole he Gene General i keʻano kuʻuna Hiki ke hōʻikeʻia ka hōʻike PD-L1 kiʻekiʻe eʻoi aku ka maikaʻi o ka mea maʻi e pono ai e pōmaikaʻi iā immunotherarapy.geneticʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution uaʻikeʻia ma o ka ho'āʻoʻana i keʻano genetic genetic,ʻikeʻiaʻo ia e like me keʻano o ka biomarker ʻO kēia hoʻokolohua e hōʻike ana i nā tissue tissue a iʻole, i loko o kekahi mau hihia, nā'āpana koko e hoʻomaopopo ai i ka uluʻana o ka maʻi maʻi maʻi. ʻO nā hopena o kēia mau hōʻike e kōkua i nā mea e kōkua i nā hoʻolālā pilikino e hoʻolālā i nā hiʻohiʻona kūʻokoʻa o kēlā me kēia mea maʻi. Hoʻohanaʻiaʻo Baafta Cancer Review Institute State-of-the-the-of genetic offsenlogiesEXEDER-ONDERSE (NGS): ʻO nā NGS kahiʻano hana hoʻohālikelike e hiki ke nānā i nā gene likeʻole. Hāʻawi kēia i kaʻikeʻana o ka nui o nā mutations a me nā loli genomic.PlymeAse chain reaction (PCR): ʻO PCR kahiʻano hana ho'āʻo houʻia e hoʻohanaʻia eʻike i nā mana kiko'ī a iʻole ka hanaʻana.ʻO ka fluorescecence i loko o kahi hybridization (iʻa): Hoʻohanaʻia ka iʻa eʻike i ka hoʻouluʻana o Genety, e like me Alk a me Rose1 Fusions.Immunonhilistchemostry (ihc): Ua hoʻohanaʻiaʻo IHC eʻike i ka hōʻike protein Pono e hanaʻia ka ho'āʻoʻana e like me ka hiki i ke kaʻina hana hoʻolālā no ka mea hiki ke noʻonoʻoʻia nā mea i nānāʻia mai ka huhū. He mea nui ia e hōʻike hou ai inā e holomua ana ke kōkuaʻana i nā mea kūʻai aku no nā mea kanu cancer i loaʻa i nā lāʻau lapaʻau cancer ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution. ^. Ua hoʻolālāʻia kēia mau mea lapaʻauʻia me ka uluʻana o ka uluʻana, maheleʻana, ma ka hoʻokaʻawaleʻana i nā mea uila i nā hopena o nā hopena maʻamau. Hoʻohanaʻia ka holomua o ka Hale Hōʻikeʻikeʻo BaafA i nā mea lapaʻau i hoʻohanaʻia i nā mea hoʻokūkū nui Hoʻopili kēia mau lāʻau lapaʻau i ka hana o ka protein egfr,ʻo ia ka mea maʻamau i loko o nā cancer carcer me kēia mau hoa hana. ʻO nā mea hoʻohana maʻamau e pili ana i nā IMFR maʻamau:Gefitinab (IRSNA)Erlolinib (tarceva)AFATINI (GILOTRIFIF)Ostiberninib (tagrisso): Pinepine ka hoʻomaʻamaʻa muaʻana o ka laina mua-line no egfr-mutated nsclc.kcork i hoʻohanaʻia e mālama i nā cancecers pungbors me nā hana alk. ʻO kēia mau lāʻau lapaʻau i hoʻopaʻaʻia i ka hana o ka faile alk E hui pū nā mea hana maʻamau:Ciorotinib (Xaltori)Alelenib (Alecensa)Ceritinib (zykadia)ʻO Brigatinib (Alunbgig)LortLinib (LRBRENA)Ua hoʻohanaʻiaʻo Ros1 Ushirastorsos1 i nā mea hana inhibitors1 e mālama i nā Canang Canancers me Ros1 Fusions Fusion. Hoʻopili kēia mau lāʻau lapaʻau i ka hana o ka protein o ka sperin,ʻo ia ka mea nui e hana pinepineʻia i loko o nā cecer camer. E pili ana nā mea hoʻohana kālā Ron1Ciorotinib (Xaltori)Entretrectib (rozlytrek)Hoʻohanaʻia nā inhiburf inhibitorbraborsborbraborbaf Hoʻopili kēia mau lāʻau lapaʻau i ka hana o ka protein braf,ʻo ia ka mea maʻamau i loko o nā cancer carcer i kēia mau'ōmole. ʻO nā mea hoʻohana maʻamau BrafDabrafenab (tafinlar)TrameokiBi (mekinist): Hoʻohana pinepineʻia ka hui pūʻana me Dabrafyib.Kras G12C IribrasSorassosib (Lrazarat) a me ADAGRATIE. Hana lākou ma ka hoʻopaʻaʻana i ka hana o ka hana o ka carin.Mmeitotherapy a me Genetic Muttanimmuntherapy a me keʻano o keʻano o ka maʻi maʻi maʻi. ʻOiaiʻo Immunotherapyʻaʻole pololei ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution, kekahi mau mutations genetic a me nā biograkes, e like me ka hua'ōlelo pd-l1 a me kaʻeha kaumaha (tmb) ʻO nā mea maʻi me nā'ōlelo PD kiʻekiʻe a iʻole ka hōʻike kiʻekiʻe a iʻole ka tmb kiʻekiʻe e pono ai e pōmaikaʻi i ka immunotherapy. Ma Shndong Baofa cancer noiʻi noiʻiʻana, hoʻohui pū me nā mea hana'ē aʻe o keʻano o ka maʻi maʻi maʻi maʻi. ʻO nā mea i kohoʻia nā mea i kohoʻia a me nā immunotherapies e hoʻomohalaʻia a ho'āʻoʻia i nā hoʻokolohua lapaʻau. Ke hana nei nā mea noiʻi eʻike hou ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution hiki ke kohoʻia me nā mea hana novel. E like me kā mākou hoʻomaopopoʻana i nā genetics of lung cancer, hiki iā mākou ke manaʻo eʻike i nā koho pilikino hou aku no nā mea maʻi. Ua hanaʻiaʻo Shandong Banuo Cancer Recovery Institute e noho ana ma ka papa mua o kēia mau mea hana LorchedInibbBlock Alk Protein Workrosanib, Entreclibblock Ron1 protein protein inika ʻO ka hoʻomaʻamaʻaʻana o Gentic Mungution he mea pono no ka hoʻomaikaʻiʻana i nā hopena no nā maʻi maʻi me ka maʻi maʻi lung. Hiki ke kōkua i ka hoʻokolohua genetic ke kōkua i nā hōʻailona kūikawā e hiki ke kohoʻia me nā mea mālama pilikino. E like me kā mākou hoʻomaopopoʻana i nā genetics o ka maʻi lungu e ulu i ka uluʻana, hiki iā mākou ke manaʻo eʻike i nā maʻi maikaʻi loa a me nā hana maikaʻi loa no kēia maʻi maʻi. Kipa Shandong banufa cancer noiʻi noiʻi E aʻo hou e pili ana i kā mākou pili pihaʻana i ka mālamaʻana i ka mālama maʻi maʻi.Hōʻike: ʻO kēiaʻikepili no nā kumu hoʻonaʻauao wale nō aʻaʻole pono e noʻonoʻoʻia i nā'ōlelo lapaʻau. E kamaʻilio mau me kahiʻoihana olakino kūpono no ka maʻi maʻi a me ka mālamaʻana i keʻano lāʻau lapaʻau. www.cancer.govʻAmelikaʻAmelika Hui PūʻIa. www.haelac.org