Cov kev kho caj tshuaj taus ntshav qab zib

Nkag siab lub luag haujlwm ntawm Cov kev kho caj tshuaj taus ntshav qab zib yog qhov tseem ceeb rau tus kheej thiab muaj mob ntsws tswj mob ntsws. Cov ntawv no tshawb nrhiav tias kev sib cav sib ceg ntawm cov ntshav mob caj dab, thiab cov kev kho mob feem ntau pom kev tuag thoob ntiaj teb, feem ntau yog tsav los ntawm Cov kev kho caj tshuaj taus ntshav qab zibCov. Cov kev hloov pauv no tuaj yeem tshwm sim hauv cov noob uas tswj hwm kev loj hlob ntawm tes ntawm tes, kev faib tawm, thiab kho. Kev txheeb xyuas cov kev sib hloov no yog qhov tseem ceeb vim tias nws tuaj yeem coj cov tswv yim kho mob thiab kho cov txiaj ntsig ntawm tus neeg mob. Ntawm Shandong Baofa Cancer Tshawb Fawb Lub Koom Haum, peb ua ntej nkag siab txog tus neeg mob caj ces.Qhov kev sib pauv ntsws?Cov kev kho caj tshuaj taus ntshav qab zib yog kev hloov pauv hauv DNA ntu uas tuaj yeem ua rau muaj kev coj txawv txav ntawm tes. Cov kev sib hloov no tuaj yeem tau txais los yog nrhiav thaum ib tus neeg lub neej. Hauv mob ntsws cancer, tau txais kev sib hloov pauv tau ntau dua thiab feem ntau tshwm sim los ntawm ib puag ncig cov khoom xws li kev haus luam yeeb lossis kev haus luam yeeb lossis kev haus luam yeeb lossis kev haus luam yeeb. Cov kev sib hloov no tuaj yeem cuam tshuam cov txheej txheem cell lub cev, ua rau kev tswj cov qog thiab cov qog ua si hauv lub ntsws mob ntsws mob ntsws. Kev nkag siab cov kev sib hloov no yog qhov tseem ceeb rau xaiv txoj kev kho mob yog. Nov yog qee qhov feem ntau:Egfr (Epidermal Kev Loj Hlob Receptor): Kev sib hloov hauv EGFF muaj ntau yam hauv cov pa mob cancer me me cancer (NSCLC), tshwj xeeb hauv Adenocarcinomas. Cov kev sib hloov no tuaj yeem ua rau cov qog nqaij hlav cancer kom nkag siab ntau rau qee yam kev kho mob.Alk (anapleLast qog ntawm lymphoma Kinase): Alk tu ncua yog lwm qhov kev hloov pauv tau pom hauv NSCLC. Alk Inhibitors tau pom tias muaj kev vam meej tseem ceeb hauv kev kho cov qog nrog qhov kev hloov pauv no.Ros1: Zoo ib yam li Alk, Ros1 fusion tuaj yeem tsav tsheb ntsws mob qog nqaij hlav. Ros1 Inhibitors muaj rau cov neeg mob nrog Ros1-NSCLC.BRAF: Kev sib hloov, tshwj xeeb yog V600E kev sib hloov, tuaj yeem nrhiav tau hauv NSCLC. Braf Inhibitors tuaj yeem siv los ua hom kev hloov pauv no.KRAS: Kras hloov pauv tau tshwm sim hauv ntsws adenocarcinoma. Thaum lawv nyuaj rau lub hom phiaj, cov kev kho tshiab yog los kho cov qog nqaij hlav KRAS.PD-L1 (programmed Tuag-Ligand 1): Thaum tsis yog cov gene sib hloov hauv cov ib txwm nkag, PD-L1 qhia yog kev qhia uas tuaj yeem twv xyuas cov lus teb rau kev tiv thaiv. Cov lus qhia pd-L1 yuav qhia tau tias tus neeg mob muaj txiaj ntsig ntau dua los ntawm kev tshuaj tiv thaiv kab mob npaws "Cov kev kho caj tshuaj taus ntshav qab zib yog txheeb xyuas los ntawm kev kuaj keeb kwm kev twv txiaj, tseem hu ua biomarker kuaj lossis molecular profiling. Qhov kev ntsuas ntsuas qog nqaij daim qog lossis, qee kis, cov kab mob ntshav los txheeb xyuas cov kev hloov pauv ntawm cov keeb kwm kev hloov pauv tshwj xeeb uas yog tsav tsheb cancer kev loj hlob. Cov txiaj ntsig ntawm cov kev xeem no pab oncologists tus kheej cov phiaj xwm kev kho mob los tsom tus yam ntxwv tshwj xeeb ntawm txhua tus neeg mob cancer. Lub Tsev Haujlwm Tshawb Fawb Cancer Baofa Siv----art-the-the-the-the-the-the-the-the-the-the-theenTom ntej-Generation exctrencing (NGS): NGS yog txoj kev xeem uas tuaj yeem tshawb xyuas ntau cov noob ntawv ib txhij. Qhov no tso cai rau kev kuaj pom ntawm ntau yam kev sib hloov thiab lwm yam kev hloov pauv GUTOMIC.Polymerase Coawe (PCR): PCR yog ib txoj kev ntsuas kev ntsuas ntxiv uas tau siv los kuaj cov kev sib raug zoo lossis cov vene rearrancements.Fluorescence nyob rau hauv situ hybridization (ntses): Ntses siv tau los tshawb xyuas cov gene rearrancements, xws li Alk thiab Ros1 fusions.Immunohistochemistry (IHC): IHC yog siv los kuaj cov protein qhia, xws li PD-L1, uas tuaj yeem pab twv kom pom tseeb tias muaj kev kuaj caj ces Kev xeem yuav tsum tau ua kom ntxov li ntxov tau hauv txoj kev npaj ua tswv yim li ntawd cov kev kho mob uas tau txiav txim siab los ntawm qhov pib. Nws kuj tseem ceeb kom rov kuaj yog tias kev kho mob qog noj ntshav yog cov tshuaj kho mob tshiab ua yeeb yam tshwj xeeb mob cancer hlwb nrog tshwj xeeb Cov kev kho caj tshuaj taus ntshav qab zibCov. Cov kev kho mob no tau tsim los cuam tshuam nrog kev loj hlob, faib, thiab kis cov qog nqaij hlav cancer thaum tsis tshua muaj kev puas tsuaj rau cov hlwb ib txwm muaj. BaofA tsev kho mob tus tshuaj xyuas cov tshuaj uas tau txais kev kho mob tshiab.egf in inhibitionsegrators tau siv los kho cov ntsws mob ntsws nrog EGFr hloov. Cov tshuaj thaiv no cov kev ua ntawm EGFR protein, uas feem ntau ua rau mob qog nqaij hlav cancer nrog cov kev hloov pauv no. Xws li EGFR inhibitors xws li:Gefitinib (Iressa)Erlotinib (Tarceva)Afatinib (Gilotrif)Osimertinib (TaxsisTo): Feem ntau kho rau EGF-Mutated NSCLC inhibitorsalk inibitors yog siv los kho cov ntsws mob ntsws nrog cov kua zaub. Cov tshuaj thaiv no cov kev ua ntawm cov alk protein, uas feem ntau ua tsis taus cov qog nqaij hlav cancer nrog cov kev rov qab los. Alk Incoleative Alk Inhibitors muaj xws li:Crizotinib (xalori)Alectinib (alecensa)Ceritinib (ZYKADIA)Brigatinib (Alunbrig)Lorlatinib (Lorbrena)Ros1 Inhibitorsros1 Inhibitors tau siv los kho cov mob ntsws mob ntsws nrog Ros1 fusions. Cov tshuaj thaiv no cov kev ua ntawm Ros1 protein, uas feem ntau tsis tshua muaj mob qog nqaij hlav cancer nrog cov fusion. Cov Ros1 Incibitors nquag muaj:Crizotinib (xalori)Entrectinib (rozlystrek)Braf InhibitorsBrafa Inibitors tau siv los kho cov ntsws mob ntsws nrog rau kev sib hloov, tshwj xeeb yog V600E kev sib hloov. Cov tshuaj thaiv no cov kev ua ntawm cov prof prof, uas feem ntau ua rau mob qog nqaij hlav cancer nrog cov kev hloov pauv no. Cov Braf Inhition Inhibitors xws li:Dab Neeg (TAFINLAR)Trametinib (Mekinist): Feem ntau siv hauv kev sib xyaw ua ke nrog Dab Neeg Lawv ua haujlwm los ntawm kev thaiv cov kev ua si ntawm KRAS cov kev sib cav ntawm kev kho mob caj dab thiab kev tiv thaiv kab mob cancer uas tiv thaiv mob cancer. Thaum immunotherapher tsis ncaj qha lub hom phiaj Cov kev kho caj tshuaj taus ntshav qab zib, qee qhov kev sib nrig sib tsam genetic thiab biomarkers, xws li PD-L1 qhia thiab cov lus qhia cov lus qhia Cov neeg mob uas muaj cov ntawv tshaj-L1 lossis siab TMB yuav muaj txiaj ntsig zoo dua los ntawm kev txhaj tshuaj tiv thaiv kab mob. Ntawm Shandong Baofa Cancer Tshawb Fawb, peb ua ke kev kho mob qog noj ntshav rau kev kho mob ntsws uas muaj kev kho mob ntsws sai sai. Cov kev kho mob tshiab thiab cov tshuaj tiv thaiv kab mob tau raug tsim thiab kuaj hauv kev sim tshuaj. Cov kws tshawb nrhiav kuj ua haujlwm los txheeb xyuas qhov tshiab Cov kev kho caj tshuaj taus ntshav qab zib uas tuaj yeem tsom nrog kev kho mob tshiab. Raws li peb txoj kev nkag siab txog cov noob caj noob ces mob qog nqaij hlav zaws, peb tuaj yeem cia siab tias yuav pom cov neeg mob tus kheej thiab muaj txiaj ntsig zoo rau cov neeg mob. Shanga Cancer Tshawb Nrhiav Lub Koom Haum tau ua haujlwm rau ntawm qhov kev tsim kho ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob ntawm cov kev kho mob no: Alk Protein Actos1crizotinib, entrectinibblock Ros1 protein kev ua yeeb yam kras gulas protein kev ua siconconcented lub luag haujlwm ntawm Cov kev kho caj tshuaj taus ntshav qab zib yog qhov tseem ceeb rau kev txhim kho cov txiaj ntsig zoo rau cov neeg mob ntsws cancer. Kev Tshuaj Ntsuam Txog caj ces tuaj yeem pab txheeb xyuas cov kev hloov pauv tshwj xeeb uas tuaj yeem npaj nrog cov kws kho mob ntiag tug. Raws li peb txoj kev nkag siab txog cov noob caj noob ces cov kabmob tseem loj tuaj ntxiv, peb tuaj yeem cia siab tias yuav tau txais kev kho mob ntau dua thiab cov hom phiaj rau kev mob no. Xyuas Shanga Cancer Tshawb Fawb Txog Lub Koom Haum Xav paub ntau ntxiv txog peb txoj kev ua kom mob ntsws ntsws.Tsis paub tseeb: Cov ntaub ntawv no yog rau lub hom phiaj kev kawm nkaus xwb thiab tsis txhob txiav txim siab kho mob. Ib txwm sab laj nrog tus kws kho mob tsim nyog rau kev kuaj mob thiab kho cov mob cancernational. www.cancer.govAmerican Cancer Society. www.cancer.org