RCC Renal Cell Carcinoma

RCC (Lub raum ntawm lub tsheb carcinom) yog feem ntau hom raum cancer hauv cov neeg laus. Cov ntawv no tshawb nrhiav tus kab mob, npog nws hom, cov tsos mob, kuaj mob, kev kho mob, thiab kev kho mob. Lub Cim Ntawm Lub Carcinom Calberoma?Lub cev ntawm lub cev Carcinoma (RCC), los yog mob raum, keeb kwm nyob rau hauv lub ob sab phlu convolution convoluted trackrute, ib feem ntawm cov leeg me heev hauv lub raum uas lim cov ntshav thiab tshem cov khoom pov tseg. Nkag siab txog ntau hom thiab theem ntawm Rcc yog qhov tseem ceeb rau kev kho kom zoo. Hom ntawm Lub Cim Ntawm Lub Carcinom CalberomaOb peb subtypes ntawm Rcc muaj nyob, txhua tus muaj cov yam ntxwv sib txawv thiab kev kho mob. Cov hom feem ntau suav nrog: ntshiab cell Lub Cim Ntawm Lub Carcinom CalberomaQhov feem ntau sib zog subtype, suav nyiaj kwv yees li 70% ntawm Rcc . Nws yog tus cwj pwm los ntawm cov hlwb uas tshwm sim los yog daj ntseg hauv qab lub tshuab tsom vim yog cov ntsiab lus lipid siab. Tau qhov twg los: American Cancer SocietyPaparary Lub Cim Ntawm Lub Carcinom CalberomaQhov thib ob feem ntau hom uas feem ntau, muaj txog li 10-15% ntawm cov neeg mob. Paparary Rcc yog tus cwj pwm los ntawm cov ntiv tes-zoo li projections hu ua papillae. Feem ntau nws cuam tshuam nrog qee yam kev mob caj ces. Muaj ob lub ntsiab subtypes: Hom 1 thiab hom 2, nrog ntaus 2 feem ntau ua kom nruj. Chromophebe Lub Cim Ntawm Lub Carcinom CalberomaQhov no subtype sawv cev kwv yees li 5% ntawm Rcc . Chromophebe Rcc feem ntau muaj qhov zoo dua qhov piv txwv rau kom meej me ntsis RccCov. Lub hlwb loj dua thiab paler dua li ntshiab cell Rcc Cell.Collecting duct Lub Cim Ntawm Lub Carcinom CalberomaIb qho kev tsis tshua muaj thiab txhoj puab heev subtype, suav rau tsawg dua 1% ntawm cov neeg mob. Kev Sau Quav Rcc tshwm sim nyob rau hauv kev sau cov duct ntawm lub raum, uas thauj cov zis rau lub zais zis. Nws yog feem ntau kuaj pom ntawm theem tom ntej thiab tuaj yeem nyuaj los kho.Lub Lub Cim Ntawm Lub Carcinom CalberomaLwm qhov tsawg thiab kev txhoj puab heev subtype, feem ntau cuam tshuam cov tib neeg nrog cov lej cell sickle. Medparary Rcc feem ntau cuam tshuam nrog cov txiaj ntsig tsis zoo.Symptoms ntawm Lub Cim Ntawm Lub Carcinom CalberomaTheem thaum ntxov ntawm Rcc tej zaum yuav tsis muaj cov tsos mob tshwm sim. Txawm li cas los xij, raws li lub qog nqaij, cov tsos mob ntawm cov zis tsis zoo (Hematuria Lub Cim Ntawm Lub Carcinom CalberomaKev kuaj Rcc Feem ntau cuam tshuam nrog kev kuaj lub cev, kev kuaj cov kev sim, thiab kev sim biopsy.simıqhov kev sim ua si lub luag haujlwm tseem ceeb hauv kev kuaj pom thiab theem RccCov. Cov kev ntsuas uas tsom xam muaj xws li: Sib piv Tomography (CT) Luam Ntawv: Muab cov ncauj lus kom ntxaws ntawm cov duab ntawm lub raum thiab ib puag ncig cov ntaub so ntswg. Sib nqus resonance tsom (MRI): Muaj cov ntaub so ntswg zoo sib xws thiab muaj txiaj ntsig tshwj xeeb rau kev soj ntsuam cov qog thiab kuaj pom rau cov qauv nyob ze. Ultrasound: Tuaj yeem pab sib txawv ntawm cov khoom loj thiab cov kua dej puv plab hauv lub raum. Lub raum zais (angiography): Lub xoo hluav taws xob kuaj ntawm cov hlab ntsha lub raum tom qab zas xim tau txhaj. Nws yog siv tsawg dua ct lossis mri.beApsya biopsya muaj cov qauv me me ntawm cov nqaij raum rau kev tshuaj ntsuam nyob rau hauv lub tsom iav. Kev cob qhia yog qhov tsim nyog kom paub meej tias kev kuaj mob ntawm Rcc thiab txiav txim siab subtype. Cov duab-coj cov paj lug muaj feem ntau tau siv CT lossis ultrasound kom ntseeg tau tias qhov kev sib tw yog qhov txawv txawv. Theem ntawm Lub Cim Ntawm Lub Carcinom CalberomaTheem ntawm Rcc Hais txog qhov tseeb ntawm tus mob cancer thiab seb nws tau kis mus rau lwm qhov chaw ntawm lub cev. Staging yog qhov tseem ceeb rau kev txiav txim siab cov kev kho mob tsim nyog thiab kwv yees qhov ntsuas tau. TNM (qog, ntawm, Metastasis) Staging system feem ntau siv: T (qog): Piav qhia qhov loj me thiab raws li thawj cov qog. N (Node): Qhia hais tias tus mob cancer tau kis mus rau cov qog noj ntshav nyob ze. M (Metastasis): Qhia hais tias tus mob cancer tau kis mus rau deb chaw nyob deb, nrog rau theem thiab theem ntxov tshaj plaws yog qhov kev xaiv ntau tshaj.Qhov kev xaiv rau Lub Cim Ntawm Lub Carcinom CalberomaKho rau Rcc Nyob ntawm ntau yam, suav nrog rau theem ntawm mob cancer, tus neeg mob txoj kev noj qab haus huv tag nrho, thiab kev nyiam tus kheej. Cov kev xaiv cov kev xaiv ntau yam suav nrog kev tshem tawm cov qog yog feem ntau ua ntej kev kho mob rau hauv nroog Rcc (Theem I-III). Kev tsim kho cov kev xaiv muaj xws li: Ib feem methrectomy: Tshem tawm ntawm tsuas yog cov qog thiab ib co npoo me me ntawm cov ntaub so ntswg zoo. Cov kauj ruam no yog nyiam thaum muaj peev xwm khaws cia raum ua haujlwm. RADAL NETRECTOMY: Kev tshem tawm ntawm tag nrho lub raum, nrog rau cov ntaub so ntswg loj, xws li cov yeeb yaj kiab thiab cov qog ntshav. Qhov no feem ntau ua rau cov hlav loj los yog thaum ib nrab ntawm Neptargy tsis yog tshuaj uas muaj tshuaj uas muaj cov tshuaj tua kab mob cancer thiab muaj sia nyob. Cov tshuaj no tuaj yeem ua haujlwm tau zoo Rcc (Theem IV) thiab tseem siv tau nyob rau hauv cov theem ua ntej hauv qee kis. Piv txwv li: Vegf inhibitors: Sunitinib (Sutent), Sorafenib (Nexavar), Pazopanib (VoTrient), Axitinib (Bevacizumab (AVASTA) Mtor Inhibitors: Temsirolimus (Tunisel), EvinialS (Afinorit) Kev txhaj tshuaj tiv thaiv cov tshuaj pab lub cev tiv thaiv thiab tua kab mob hlwb. Kev txhaj tshuaj tsis huv tau pom tias muaj kev cog lus tseem ceeb hauv kev kho siab RccCov. Piv txwv li: PD-1 Inhibitors: Nivolumab (OPDIVO), Pembrolizumab (Keytruda) CTLA-4 inhibitors: Ipilimimab (Yervoy) Ua ke immunotherapy: Nivolumab ntxiv rau cov kev kho mob IpilagumetabotThother tej zaum yuav raug siv nyob rau qee cov xwm txheej, xws li: Kev Siv Hluav Taws Xob: Siv cov hluav taws xob siab rau tua cov kabmob kheesxaws. Nws tsis yog siv ntau rau Rcc, tab sis nws yuav siv los kho cov pob txha metastases lossis daws qhov mob. Kev kho mob abl muab: Cov tswv yim zoo li hluav taws xob radiofrequency ablation (RFA) lossis sryoabation siv kub lossis txias kom rhuav tshem cov qog. Cov no yuav siv rau cov qog me me hauv cov neeg mob uas tsis yog cov neeg sib tw zoo rau kev phais mob. Cov kev soj ntsuam nquag: Rau me me, qeeb kev soj ntsuam, kev soj ntsuam nquag (kev soj ntsuam ze) yuav yog qhov kev xaiv hloov kho tam sim ntawd.pogosis ntawm Lub Cim Ntawm Lub Carcinom CalberomaQhov preemosis ntawm Rcc Kev sib txawv nyob ntawm ntau yam, suav nrog rau theem ntawm mob cancer, tus neeg mob subtepe, thiab tus neeg mob muaj kev noj qab haus huv tag nrho. Ntxov paub thiab kho ntxov yog qhov tseem ceeb rau kev txhim kho cov txiaj ntsig. Raws li Lub Koom Haum Cancer National Cancer Lub Chaw Haujlwm Sea Seer, 5-xyoo txheeb ze muaj sia nyob tus nqi rau hauv zos Rcc (Cancer uas tsis tau nthuav tawm sab nraud lub raum) yog siab. Txawm li cas los xij, tus nqi muaj sia nyob tsawg tsawg rau cov theem ntawm tus kab mob. 5-xyoo tus txheeb ze muaj txoj sia nyob rau lub raum ntawm lub cev muaj nuj nqis hauv zej zog ua ke 73% tag nrho cov neeg seer) nyob rau txhua lub sijhawm 76% cov lej no yog raws cov neeg uas tau kuaj pom Rcc Ntau xyoo dhau los, yog li cov nqi ciaj sia tau siab dua tam sim no vim nce rau kev nce qib hauv kev kho mob. Lub Cim Ntawm Lub Carcinom Calberoma, tshawb txog cov kev tshawb fawb pib ntawm Shanga Cancer Tshawb Fawb Txog Lub Koom Haum, mob siab rau kev saib xyuas cancer.