Ubushinwa Ibishya Bito Bito Kuvura Kanseri y'ibihaha

# Ubushinwa bushya bwo kuvura kanseri ya kanseri ya kanseri ya kanseri ya kanseri ya kanseri idafite kanseri ntoya (NSCLC) ihora ihinduka mu Bushinwa. Iyi ngingo itanga incamake yo gutera imbere iheruka, yibanda kuri traprapies igamije, imbura, hamwe nubundi buryo bushya bugera kubarwayi. Tuzasesengura ahantu nyaburanga Ubushinwa bushya bwo kuvura kanseri karemano, kwerekana ibitekerezo byingenzi kubarwayi nabarera.

IGITABO KUBA MURI NSCLC MU BUHAMBE

Abafite amashanyarazi bashushanyijeho iterambere rikomeye muri Ubushinwa bushya bwo kuvura kanseri karemano. Izi nyungu zigamije cyane cyane ihinduka rya genetike ritwara imikurire yingirabuzimafatizo. Ubuvuzi butandukanye bugamije bwerekanye imikorere idasanzwe mugutanga ubuzima no kuzamura imibereho kubarwayi bafite ihinduka rya mutation yihariye.

Ubugizi bwa Egfr

Imikurire yimiterere ya reseptor (EGFR) ihinduka rirasanzwe muri NSCLC, cyane cyane mubarwayi batigeze banywa itabi. EGFRY Tyrosine Kibititers (TKIS), nka Gefitinib, Erlotinib, Aftinib, Ositinib, Ositinib, aboneka mu Bushinwa kandi aboneka mu Bushinwa kandi agaragaza imikorere ikomeye mu kuvura egfr-yahindutse NSCLC. Ibi biyobyabwenge bihagarika inzira yamabati ya EGFR, kubuza ibibyimba. Guhitamo egfr-tki biterwa nibintu nkubwoko bwa egfr mutation nubuzima bwumurwayi muri rusange. Ingaruka nimpande ziri ziratandukanye hagati yiyi miti.

ALK Abagizi ba nabi

Anaplastic lymphoma kinase (ALK) Imyitozo ngororamubiri nubundi buryo busanzwe butagereranywa muri NSCLC. ALK Abagizi ba nabi, nka cnzitinib, ceritinib, voletinib, na brigatinib, bagamije neza iyi muco. Kimwe nubwo esfr tkis, guhitamo alk ikwiye alk irimo ibintu nkibisobanuro byihariye bya alk.

Izindi mbuga zagenewe

Hanze ya egfr na alk abarashi, izindi mbuga zigamije kuboneka mubushinwa kubarwayi ba NSCLC bafite imyanya yihariye. Ibi birimo imirongo yibasiye ihinduka rya Ros1, subiza, na Braf, nibindi. Kuboneka no kugerwaho ubuvuzi birashobora gutandukana mu karere mu Bushinwa. Gukomeza kumenyeshwa binyuze mu nama hamwe nabatedozi ni ngombwa kugirango ubone aya mahitamo agezweho.

Imbura ya NSCLC mubushinwa

Impunotherafay ibihonga imbaraga zumubiri wumubiri wo kurwanya kanseri. Ubu buryo bugereranya impinduka ya paradiji muri Ubushinwa bushya bwo kuvura kanseri karemano kandi yerekanye intsinzi idasanzwe mugutezimbere ibisubizo kubarwayi benshi.

Gukurikirana imbine

Gugenzura imbile (ICIS) nicyiciro cyibiyobyabwenge bidahwitse guhagarika poroteyine zifasha kanseri ifasha sisitemu yumubiri. Intego ebyiri zingenzi za ICIS ni gahunda y'urupfu-1 (PD-1) kandi yateguwe n'urupfu-Ligand 1 (PD-L1). Pembezimab, NIVOLUMAB, na Sintilimab ni ingero za PD-1 / PD-L1 abarashi bemerewe mubushinwa kuri NSCLC. Gukoresha ICIS bikunze kuyoborwa na PD-L1 imvugo mubyigiri, nubwo imikorere yabo igera kure ya PD-L1 imiterere mubihe bimwe. Gukurikirana neza ingaruka zishobora kuba ari ngombwa.

Ubundi buryo bushya bwo kuvugurura

Ubushakashatsi bukomeje bukomeje gutwara udushya mu kuvura NSCLC. Ubuvuzi bwo mushyanga, harimo amashanyarazi agenewe ibinyabuzima bugaragara, bihuza impfuyika hamwe nibikoresho bigamije, nibindi bisobanuro byegeranye, biri gukorwa kugirango bigire ingaruka mubikorwa byubuvuzi. Umurima uragenda vuba, kandi usanzwe ugisha inama abatanga ubuzima bwihariye ni ngombwa kugirango ukomeze kuvugururwa kumateraniro aheruka. Kumakuru nyayo kandi agezweho, nyamuneka ubaza umuganga wawe.

Guhitamo ubuvuzi bwiza

Uburyo bwo kuvura neza kuri NSCLC mubushinwa bwihariye kandi buterwa nibintu byinshi birimo icyiciro cya kanseri, ihinduka rya genetike rihari, ubuzima rusange bwumurwayi, kandi kuboneka kubitabo byihariye. Ibiganiro na Oncologied Inzobere muri kanseri y'ibihaha ni ngombwa mugutezi agaciro ingamba zikwiye kandi zifatika. Shandong Baofa Kanseri Ikigo cyubushakashatsi (https://www.baofahospasdatan.com/) nicyo kigo cyambere mubushinwa gutanga ubwitonzi bwambere.

Ingaruka zo kuvura no gucunga

Kuvura kwa kanseri, harimo na NSCLC, birashobora kugira ingaruka mbi. Izi ngaruka mbi ziratandukanye bitewe nubuvuzi bwihariye numurwayi wa buri muntu. Gufungura kumugaragaro hamwe nitsinda ryubuzima bwawe kubyerekeye ingaruka zose ningirakamaro kugirango ibageke neza. Serivisi zifasha ningamba zo gucunga impande ziboneka kugirango ihumure nubuzima bwose mubuzima bwose.

Umwanzuro

Imiterere ya Ubushinwa bushya bwo kuvura kanseri karemano ni imbaraga no gusezerana. Iterambere mu buvuzi bugamije, Impindurarorapy, no ku bundi buryo butanga ibyiringiro ku barwayi. Kumenya hakiri kare no kwisuzumisha ni ngombwa kugirango ugere kumahitamo akwiye kandi meza. Gukorana cyane nitsinda ryanyu ryubuzima ni ngombwa kugirango uyobore ibintu bigoye bya NSCLC no kugwiza amahirwe yo kuzamuka neza. Wibuke kugisha inama oncologue yawe kugirango muganire ku iterambere riheruka kandi gahunda nziza yo kuvura ibihe byawe.