Kuvura karcinoma ya renal: Icyerekezo cya patologiya

Iki gitabo cyuzuye gishakisha pathologiya ya karcinoma ya renal selile (RCC), yirukana muburyo butandukanye, uburyo bwo gusuzuma, hamwe nibisobanuro byo kuvura ingamba. Dusuzuma ibintu bya microscopique, guhinduranya ibipimo, hamwe nibintu byabi baregwa bifitanye isano na RCC, gutanga imyumvire irambuye kubanyamwuga nubuvuzi.

Gusobanukirwa Ingoma ya Corkor

Gusobanura RCC na Sundtypes

Renal Carcinoma ya Renal, Ubwoko bwa kanseri ikunze kugaragara, ikomoka mu ndirimbo yimpyiko. Ubuso bushya bubaho, buri kimwe gifite ibintu bitandukanye cyane hamwe nimyitwarire yubuvuzi. Muri byo harimo selile isobanutse RCC (CCRCC), Papillary RCC (PMCC), Chromoso RCC (ChRECC), nabandi. Kumenyekanisha neza ni ngombwa mu kuyobora Kuvura renal selile karcinoma patcinoma pathologiya no guhanura prognose. Ibyiciro bishya bishingiye kubizamini bya microscopique witonze hamwe na immunohistochemical, akenshi bisaba ubuhanga mubikorwa bya genotouriry.

Microscopique Ibiranga kandi ibipimo byo gusuzuma

Isuzuma rya RCC rishingiye cyane cyane kuri hestortologiya yipimisha imiti ya Tissue yakuwe mu biopsy cyangwa kubaga. Ibiranga microscopique yihariye, nka morphologiya ya selile, ibiranga ibidukikije, no gukura, gufasha gutandukanya RCC suttypes. Kurugero, CCRCC irangwa na cytoplasm isobanutse, mugihe PRCCHIMS Ubwubatsi bwa Papillary. ImmongoOStoCochemie igira uruhare runini mu kwemeza isuzuma no kumenya subtypes yihariye, gufasha kunonosora Kuvura renal selile karcinoma patcinoma pathologiya gahunda.

Guhindura genetike na patologiya

Uruhare rwa genetiki mugutezimbere RCC

Genetike idasanzwe ifite uruhare runini mugutezimbere no gutera imbere kwa RCC. Guhindura abantu benshi bikubiyemo von hippel-lindau (VHL) ibibyimba bya Gene, cyane cyane muri CCRCC. Izindi genes, nka pmborm1, Bap1, na Setd2, nabo bakunze gutandukana muburyo butandukanye bwa RCC. Gusobanukirwa ubu buryo bwa genetike ningirakamaro kugirango utezimbere imitsi igamije no kuzamura umusaruro wihanga. Ubuhanga bwateye imbere, kimwe gikurikira-gisekuru gikurikira, kigenda gikoreshwa mu kumenya ibyo guhindura, kumenyesha Kuvura renal selile karcinoma patcinoma pathologiya Uburyo.

Ingaruka zatewe no kuvura

Kumenyekanisha ihinduka ry'ibidukikije muri RCC byatumye habaho imiti igamije. Kurugero, ibibuza ibintu byiterambere byimibare (vegf) hamwe nintego yinyamabere ya rapamycin (Mtor) ikoreshwa muri RCC yateye imbere, cyane cyane abafite VHL. Aba bakozi bagenewe bakunze kwerekana inyungu zikomeye zuzuye no kunoza umubare urokoka. Ubushakashatsi bukomeje muri Falecular Dispinsings ya RCC isara ikomeza guha inzira yo kuvugurura ibintu byiza bigamije kandi ingamba zifatika.

Impamvu mbi hamwe ningamba zo kuvura

Guteganya Guhitamo Ibikorwa no Guhitamo

Ibintu byinshi bigira ingaruka ku byaha bya RCC, harimo icyiciro cya kabiri, amanota, na subtype. Kuba hari indwara ya Metastatike igira ingaruka zikomeye kurokoka. Ibiranga pathologiya, nkibiciro bya kirimbuzi na necrosis, nabyo bigira uruhare mubyiciro bya prognostic. Iyi isuzuma rirambuye rya patologiya ni ngombwa mugutega imyanzuro yo kuvura no kudoda uburyo bwo kuvura bujyanye nabarwayi kugiti cyabo. Guhitamo Kuvura renal selile karcinoma patcinoma pathologiya Biterwa cyane kuri iri suzuma.

Amahitamo yo kuvura hamwe na patologiya yabo

Ingamba zo kuvura RCC ziratandukanye bitewe na stage nicyiciro cyindwara. Gutandukana no kuvurwa kwambere kwa RCC. Kuri RCC cyangwa Metastatike RCC, sisitemu ya sisitemu nkabakozi bagenewe cyangwa impfubyi barakoreshwa. Guhitamo kwivuza akenshi biyoborwa nubuso bwa patologiya, guhinduranya ibipimo, nubuzima bwumurwayi muri rusange. Ubushakashatsi bukomeje burakora uburyo bushya bwo kuvura butangaje, dutanga gusobanukirwa uburyo bushimishije butwara iterambere rya RCC.

Tekinike yambere muri RCC Pathology

ImmonahStochemie na Porogaramu yayo

ImpfunhistoChiphisgems (IHC) nikikoresho kitagereranywa muri RCC Pathology. Ibimenyetso byihariye, nka VHL, AMR, na Pax8, bikoreshwa mukumenya RCC sustypes kandi bitandukanya nibindi bibyimba. IHC irashobora kandi gufasha mugusuzuma icyiciro cyo kwikinisha no guhanura prognose. Byongeye kandi, IHC igira uruhare rukomeye mu kumenya intego zishobora gutanga ibitekerezo, kumenyesha yihariye Kuvura renal selile karcinoma patcinoma pathologiya ibyemezo.

Ubuhanga bwa patologiya

Ubuhanga bwateye imbere, nko gukurikiranya igisekuru gikurikira (Ngs) na Fluorescence muri Ahantu hbriditisation (amafi), bigenda bigaragara cyane muri RCC Pathology. Ngs yemerera imyigaragambyo yuzuye, kumenya imiterere nini ya geneti ishobora guhindura ihitamo ryo kuvura no guhanura igisubizo cyubuvuzi. Amafi arashobora kumenya ibintu bidasanzwe bya chromosomal bidasanzwe, bitanga ubushishozi mubinyabuzima bibinyabuzima no kuba prognose.

Amakuru yatanzwe hano ni agamije kwiga gusa kandi ntabwo ari inama zubuvuzi. Kugirango usuzume no kuvura karcinoma ya renal renal, nyamuneka mugisha inama yumwuga wubuzima bwiza.

Kubindi bisobanuro no gushyigikirwa, tekereza gusura Uwiteka Shandong Baofa Kanseri Ikigo cyubushakashatsi Urubuga. Batanga ibikoresho byingirakamaro nubuhanga mu kwita kuri kanseri.