Targeted kutumira kwedhorobha kwekenza: Nhungamiro yakazara 

Targeted kutumira kwedhorobha Zvinangwa zvekuvandudza kurapwa kwekubata uye kuderedza mhedzisiro nekusarudza kuendesa vatambi vezviratidziro kune cancer celecs celecer.net Iyi nzira inokweretesa vatakuri vakasiyana siyana uye vanonongedza mazano ekuwedzera kuunganidzwa kwezvinodhaka mukati mebundu microdenronment, rinotungamira kudzvanyiswa nemhedzisiro yemurwere.

Kunzwisisa Targeted kutumira kwedhorobha

Chii Targeted kutumira kwedhorobha?

Targeted kutumira kwedhorobha Iyi nzira yakasarudzika yekupa mushonga wakananga kumasokisi cancer. Kusiyana nechirongwa chechidzitiro, chinobata muviri wese, zvakanangwa zvekutumira masisitimu kutarisa pakuendesa zvinodhaka zvakananga kune iyo bundu saiti. Iyi nzira inoderedza kukuvadza kune hutano hwematikirwo uye inoderedza mhedzisiro yakakura kazhinji inowanzoenderana ne cancer cancer marapirwo.

Nei iri Targeted kutumira kwedhorobha Zvakakosha?

Chinangwa chikuru che Targeted kutumira kwedhorobha ndeyekuwedzera kushanda kwe cancer kurapwa uku uchideredza iyo ine chepfu mhedzisiro pamasero ane hutano. Nekununura zvinodhaka zvakananga kune bundu racho, zvakakwirira zvekutarisa kwemuratidziro wemubvumo anogona kuwanikwa panzvimbo yakatarwa, achivandudza mikana yekubudirira kurapwa. Izvi zvakare zvinoderedza kuratidzwa kwehurongwa kune zvinodhaka, zvichitungamira kune mashoma uye mashoma mativi mhedzisiro yemurwere.

Nzira dzekuenda Targeted kutumira kwedhorobha

Passive Targeting

Passive tarisiro inovimba nehunhu hwepanyama dzevhu, dzakadai seyadzo dzekusvetuka dzemvura uye dzakaremara lymphatic kudhonza, kubvumira zvinodhaka kuti uunganidze muTumor microdentement. NAANOPATICCICChicles ine saizi yakakodzera uye nzvimbo dzepamusoro dzinogona kushandisa izvi zvimiro zvekutarisa tarisiro tumor. Mumwe muenzaniso ndehombodo dzesarudzo dzinoshambidzika vessicles dzakaumbwa ne lipid bilay.

Inoshanda chinangwa

Inoshanda chinangwa inosanganisira kugadzirisa vatakuri vezvinodhaka neyechinongedzo chivharo chinosunga vanogamuchira zvakawoneka pamatehwe emanani. Uku kudyidzana kunoita kuti usarudze kwekutakura zvinodhaka ne cancer cell. Zvakajairika ligands zvinosanganisira antibodies, mapepeti, uye aptamers.

Kukurudzira-kuteerera zvinangwa

Stimuli-inonakidza chinangwa chinoshandisa mamiriro emukati kana zvekunze, zvakadai saP, tembiricha, kana mwenje, kukonzeresa zvinodhaka zvinodhaka panzvimbo yebundu. Iyi nzira inobvumira kudzora chaiko pamusoro pekutakura zvinodhaka, kuwedzera iyo yekurapa inoshanda apo kuderedza-chinangwa. Ph-inongwirwa nanharticles, semuenzaniso, kusunungura kwavo zvinodhaka kubhadhara munzvimbo yematareji ebundu microdentement.

Vatakuri vanoshandiswa mukati Targeted kutumira kwedhorobha

NANOPATCICCLICCICLESS

Nanoparticles inoshandiswa zvakanyanya sevatakuri mukati Targeted kutumira kwedhorobha Nekuda kwehukuru hwavo hushoma, nzvimbo yakakura pamusoro, uye inosiyana. Ivo vanogona kugadzirwa kubva kune dzakasiyana siyana zvinhu, kusanganisira lipids, polymers, uye inorganic makomendi. Nuoparticles inogona kuunganidzwa kuti ishandise zvinodhaka, chivadzivirira kubva mukushatisa, uye kufambisa kutumirwa kwavo kwakanangidzirwa kuCancer masero. The the Shandong baofa cancer researching Institute Inoratidza zvakasiyana neNanoparticles Insoparticles mukutsvaga kwavo kuenderera mberi kuita dzidziso yemucheche marapirwo.

Liposoms

LOSPOMES ZVIMWE ZVESE ZVESE ZVESE ZVINOGONESWA ZVAKANAKA BUPID BLELEERS. Ivo vane biocompable, biodegradable, uye inogona kusimbisa zvese hydrophilic uye hydrophobic zvinodhaka. LOSPOMS inogona kushandurwa pamwe nekuvanzika ligands kuti uwedzere kusarudzika kwavo kwemasero cancer.

Antibody-zvinodhaka conjugates (adcs)

ADCS yakaumbwa neye monoclonal Anti body yakabatanidzwa neinodhaka cyttory. Iyo Anti Provide inosarudza kubhururuka kune cancer masero, kuendesa mushonga zvakananga kune bundu resaiti. Iyi nzira inosanganisira chaiyo yehutachiona hwekurwisa ne potency yezvinodhaka zveCytotoxic.

Mienzaniso ye Targeted kutumira kwedhorobha Mukushandiswa kwekiriniki

Doxil? (Liposomal doxorubicin)

Doxil? is liposomal yakasarudzika ye doxorubicin, anthracycline chemotherapy drug. Iyo liposomal ichisimbisa yeDoxorubicin inosimbisa nguva yayo inotenderera uye inosimudzira kuunganidzwa kwayo muTumors ine leaky Vasculature. Doxil? inotenderwa kurapwa kwegomarara reovari, myloma myeloma, uye Sarcoma's Sarcoma.

Kadyla? (Trastuzumab Emtansine)

Kadyla? IS ADC inoumbwa neTrastuzumab, monoclonal Antibody iyo inotarisa yake2, yakabatanidzwa neEmtansine, iyo micretubuutuble inhibitor. Kadyla? inotenderwa kurapwa kweakara-messaiti yemazamu emazamu emazamu. Iyo Trastuzumab Chikamu cheKadyla? inosungira kumasero ake2 akanaka cancer, kuendesa Emtansine zvakananga kune bundu resaiti.

Zvinonetsa uye Nzira Dzamangwana

Kukurira zvipingaidzo zveBiological

Imwe yematambudziko makuru mukati Targeted kutumira kwedhorobha Kukurira zvipingamupinyi zvebhaibheri, senge ropa-brain barrier uye bundu microenvironi. Nzira dzekukunda izvi zvipingamupinyi zvinosanganisira kushandisa madiki naneopartticles, ichichinja zvinhu zvavo zvepamhepo, uye kushandisa zvinomutsa-zvinotevera zvinangwa.

Kuvandudza Kunaka Kwechokwadi

Kuvandudza chokwadi chekusanzwisiswa kwezvinodhaka zvekutengesa kwakakosha kuti uderedze mhedzisiro yekubvisa uye kusimudzira maitiro ekuratidzira. Izvi zvinogona kuwanikwa nekuvandudza mimwe yakasarudzika ligands, optimizing dhizaini yevatakuri vezvinodhaka, uye kushandisa musanganiswa marapirwo.

Mushonga wakasarudzika

Yakasarudzika mishonga yekushandisa inobata chipikirwa chikuru chekuvandudza kushanda kwe Targeted kutumira kwedhorobha. Nekutonga marongero ekurapa kune mamwe maitiro emurwere mumwe nemumwe uye bundu ravo, zvingave zvichiita kuti uwedzere kuendesa zvinodhaka uye zvinowedzera kurapwa. Izvi zvinogona kusanganisira kuongorora iyo genetic chimiro chebunako kuti uzive zvirevo zvakatemwa zvinodhaka.

Tafura yeFDA-yakatenderwa Inonongedzerwa Dhivha Dishm Stystems yeCancer

Disiki: Ichi chinyorwa ndechekuziva ruzivo chete uye hachifanirwe kufungwa sezano rekurapa. Bvunza neanokodzera hutano hwehutano hwekuongororwa uye kurapwa kwegomarara.