RCC renal cell carcinoma

RCC (Renal Cell Carcinoma) ndiyo inozivikanwa mhando yekanza yetsvo muvakuru. Ichi chinyorwa chinoongorora chirwere ichi, kufukidza mhando dzayo, zviratidzo, kuongororwa, sarudzo dzekurapa, uye prognosis.Zvakatoita Renal Cell Carcinoma?Renal Cell Carcinoma (RCC), kana Kenani yekanza, inobva mukumirira kweiyo Proximal Tubule Tubule, chikamu chemakwenzi madiki madiki muitsvo iyo yetsvina iyo firita iyo ropa uye bvisa zvigadzirwa zvechinguvana. Kunzwisisa mhando dzakasiyana uye matanho e Rcc yakakosha pakurapwa kunobudirira. Mhando dze Renal Cell CarcinomaAkati wandei Rcc kuvapo, imwe neimwe ine mutsauko mutsauko uye kurapwa kwakasiyana. Mhando dzakajairika dzinosanganisira: cle cle cell Renal Cell CarcinomaIyo yakanyanya kujairika subtype, accounting yeanenge 70% ye Rcc mhosva. Iyo inoratidzwa nemasero inoratidzika kunge yakajeka kana kupenya pasi pe microscope nekuda kweiyo yakakwira lipid zvemukati. Kwayaka: American Cancer SocietyPapillary Renal Cell CarcinomaYechipiri yakanyanya mhando, inosanganisira anenge 10-15% yezviitiko. Papillary Rcc inoonekwa nemunwe-semapepa emunwe anonzi Papillae. Zvinowanzobatanidzwa nezvimwe zvinhu genetic. Kune maviri main subtyplies: Type 1 uye mhando 2, ine mhando 2 kazhinji kuve kwakanyanya kurwisa. Chromohobe Renal Cell CarcinomaIyi subtype inomiririra inenge 5% ye Rcc mhosva. Chromohobe Rcc kazhinji ine prognosis iri nani kana ichienzaniswa neyekujeka cell Rcc. Masero akakura uye akapfeka kupfuura sero rakajeka Rcc masero.cllecting duc Renal Cell CarcinomaChisingaperi uye nehasha subtype, accounting pane isingasviki 1% yezviitiko. Kuunganidza duct Rcc Inomuka mumubvumirano yekuunganidza itsvo, iyo yekufambisa urini kune bladder. Zvinowanzo kuwanikwa padanho rakatevera uye rinogona kuve rakaoma kurapa.medulary Renal Cell CarcinomaImwe nguva isingawanzo uye nehasha, kunyanya kukanganisa vanhu vane excle cell maitiro. Medullary Rcc inowanzobatanidzwa nehurombo risina kunaka.symptoms dze Renal Cell CarcinomaMatanho ekutanga e Rcc inogona kusaratidza zviratidzo zvinooneka. Nekudaro, sezvo iyo bundu richikura, zviratidzo zvinogona kusanganisira: Ropa mune urini Renal Cell CarcinomaKuongorora Rcc kazhinji zvinosanganisira kusanganiswa kwekuongorora mumuviri, kufungidzira bvunzo, uye Biopsy.fund.funding maitiro ekuongorora anotamba basa rakakosha mukuona uye kuitisa Rcc. Miedzo yakajairika yekufungidzira inosanganisira: Computer Tomography (CT) Scan: Inopa yakadzama mifananidzo-chikamu cheitsvo uye tishu dzakatenderedza. Magnetic Resonance kufungidzira (MRI): Inopa zvakanakisa zvinyoro nyoro kusiyanisa uye zvinonyanya kubatsira kuti uongorore huwandu hwebunako uye kuona kupararira kune zvivakwa zviri pedyo. Ultrasound: Inogona kubatsira kusiyanisa pakati pezvakasimba masimba uye marara-akazadzwa makona muitsvo. Renal arteriography (Angiography): Iyo X-ray kuongororwa kweiyo renal arteries mushure mekunge dhayirwa yave kuiswa. Izvo zvinoshandiswa zvishoma kazhinji kupfuura CT kana MRI.biipsya Biopsy inosanganisira kubvisa sampuli diki yetsvina yetsvina yekuongorora pasi pe microscope. Biopsy inodikanwa kuti isimbise kuongororwa kwe Rcc uye sarudza iyo subtype. Mufananidzo-unotungamirwa Biopsies zvinowanzoitwa uchishandisa CT kana Ultrasound kuve nechokwadi chekutarisirwa kwakaringana kwenzvimbo yekufungidzira. Matanho e Renal Cell CarcinomaChikamu che Rcc zvinoreva huwandu hwe cancer uye kana ikapararira kune dzimwe nhengo dzemuviri. Staging yakakosha yekuona nzira yakakodzera yekurapa uye kufanotaura prognosis. Iyo tnm (bundu, node, metastasis) Staging system inowanzoshandiswa: T (bundu): Inotsanangura ukuru uye huwandu hwenguva yekutanga. N (node): Inoratidza kana cancer yakapararira kune yepedyo Lymph node. M (Metastasis): Zvinoratidza kana kenza yakapararira kunzvimbo dziri kure, dzakadai semapapu, mapfupa, kana uropi. Renal Cell CarcinomaKurapwa kwe Rcc Zvinoenderana nezvinoitika zvinoverengeka, kusanganisira iyo nhanho yekenza, hutano hwemurwere, uye zvido zvemunhu. ZVIMWE ZVAKAWANDA ZVESANGANO ZVINOGONESESA ZVINOGONESESA: Kuvhiya Kubviswa kwebunako kazhinji ndiko kurapa kwekutanga kwekodhi Rcc (Matanho i-iii). Sarudzo dzekuvhiya dzinosanganisira: Chidimbu nepeprectomy: Kubviswa kweiyo bundu chete uye chidiki chidiki chehutano hwehutano. Iyi nzira inosarudzwa pazvinogoneka kuchengetedza itsvo basa. Radical Neprectomy: Kubviswa kweiyo itsvo dzese, pamwe chete nematehwe akapoterera, senge adrenal gland uye lymph node. Izvi zvinowanzoitwa kune makomba akakura kana kana ipophial nephrectomy isinga learapytar emagetsi ekurapa anodhaka mishonga inosanganiswa nemurume wecancer muchitokisi uye kupona. Izvi zvinodhaka zvinogona kushanda mukurapa kwepamberi Rcc (Stage IV) uye inogona kushandiswawo mumatanho ekutanga mune mamwe mamiriro ezvinhu. Mienzaniso inosanganisira: Vegf Inhibitors: Sunitinib (Sutent), SoraFenib (Nexavar), Pazopanib (Votrient), Axitinib (inlyta), Bevacizumab (avastin) Moror Inhibhitors: Temslimus (Torisel), Everrolimus (AFINITE) immanhyrapyimmunotsurapy mishonga inobatsira immune system yemuviri anoziva uye kurwisa cccer masero. Immamuritherapy yakaratidza chipikirwa chakakosha pakurapa kwepamberi Rcc. Mienzaniso inosanganisira: PD-1 Inhibitors: Nivolumab (opdivo), pembrolizumab (keytruda) CTLA-4 Inhibitors: IPilimumab (Yervoy) Kusanganisa immunomtherapy: NIVOLUBABABAR PLUS IPILIMOMOTHERE KUSHANDA MABASA RINOGONA KUTI UShandiswe mune mamwe mamiriro ezvinhu, akadai se: Radiation Kurapa: Kushandisa yakakwirira-simba marangi kuuraya cancer masero. Hazvishandiswe Rcc, asi inogona kushandiswa kubata membwe yemasimbi kana kudzikamisa kurwadziwa. Ablelity kuronga: Nhungamiro dzakadai sedhizimusi redhiyo (RFA) kana kukonzeresa kushandisa kupisa kana kutonhora kuparadza bundu. Izvi zvinogona kushandiswa kune madiki madiki muvarwere vasiri vakanaka vanokwikwidza kuvhiyiwa. Active Kuongorora: Kune vashoma kwazvo, vanononoka-vanokura, vanononoka kuongorora (vhesi yekuongorora Renal Cell CarcinomaKubiridzira kwe Rcc Inosiyana zvichienderana nezvinhu zvinoverengeka, kusanganisira iyo nhanho yekenza, iyo subtype, uye hutano hwemurwere. Kuziva kwekutanga uye kurapwa kwakakosha kune zvinovandudza zvibodzwa. Maererano ne National Cancer Institute's Seer Chirongwa, iyo yemakore mashanu-yemakore ekupona huwandu hwenzvimbo yemuno Rcc (cancer iyo haina kupararira kunze kweitsvo) yakakwira. Nekudaro, iyo mwero wekupona zvinodzora zvakanyanya kune matanho ezvirwere. Mitero yechiremba 5 yeKurarama Yemari yeRenal Cell Carcinoma Stage 53% Yemari Yepazasi 71% Dunhu Rese Resenti Rcc Makore mazhinji apfuura, saka huwandu hwekupona hunogona kunge hwakakwira ikozvino nekuda kwekufambira mberi mukurapa.Formert Insight uye Yepamberi Kurongeka Kurapa Sarudzo dze Renal Cell Carcinoma, ongorora zvirevo zvekutsvagisa Shandong baofa cancer researching Institute, yakatsaurirwa kufambira mberi kufambira mberi cancer.