Targeted kutumira kwedhorobha

Targeted kutumira kwedhorobha Zvinangwa zvekuvandudza kurapwa kushamwaridzana uye kuderedza mhedzisiro nekuendesa maAratapeutic vamiririri zvakananga kumasokisi cancer, nepo kuderedza kuratidzwa kwehutano hwehutano. Iyi nzira inoshandisa nzira dzakasiyana-siyana, kusanganisira nuoparticles, antiopsies, uye mapepeti, kusarudza cancer cancer cancer masero uye kusunungura zvinodhaka panzvimbo yejira. Uku kutumirwa kwakaratuka kunowedzera kusimbisa zvinodhaka mukati mebundo, zvichitungamira kune zvakadzvanywa zvabuda uye zvakaderedza hurongwa hwekutarisa zvinodhaka zvakakwenenzverwa kwemakore, kubva kune yechinyakare chemakore kusvika kune mamwe maitiro akanyanya Targeted kutumira kwedhorobha. Chinangwa chikuru che Targeted kutumira kwedhorobha ndeyekuwedzera iyo yekuraira yemishonga yezvinodhaka paunenge uchidzora yavo ine chepfu mhedzisiro pamasero ane hutano. Izvi zvinowanikwa nekuendesa zvinodhaka zvakananga kune bundu saiti kana cancer masero, kuona kuti zvinodhaka zvinokonzeresa kwazvinonyanya kufarirwa zvakanyanya. Panguva Shandong baofa cancer researching Institute. Izvi zvinogona kutungamira kune zvakakosha mhedzisiro, sekurasikirwa kwebvudzi, kusvotwa, uye immune maitiro ekudzvinyirira, sezvo masero ane hutano anokanganiswawo nemishonga yechipoterapy. Targeted kutumira kwedhorobha Inopa akati wandei zvakanakira: Yakaderedzwa mhedzisiro: Nekutarisira cancer masero zvakananga, masero ane hutano anosanganisirwa, anotungamira kune mashoma uye mashoma mativi emhedzisiro. Yakavandudzwa Kubata: Kukwirira kwepamusoro kwemushonga kunogona kuendeswa zvakananga kuTumor saiti, kuwedzeredza kushanda kwayo. Yakawedzera Murwere Zvekunze: Zvirinani kushanda zvakanaka uye zvakaderedzwa mhedzisiro zvinogona kutungamira kune yakagadziridzwa mhando yehupenyu uye huwandu hwakapona hwekupona hwevarwere vekenza. Kukurira Kudzvinyirira Kurovedzera: Target Targeted kutumira kwedhorobha, imwe neimwe iine mashandiro aro akasarudzika ekushandisa cancer cancer concer concer Nuoparticles yakagadzirirwa kushandisa izvi zvinhu, kuunganidza zvakaringana mu bundu microdentement. Izvi zvinonzi zvakare kuwedzeredzwa kwekuvandudza uye nekuchengetwa (EPR) mhedzisiro.Achirongwa Uku kudyidzana kunoita kuti usarudze kwekutakura zvinodhaka ne cancer cell. Iyi nzira inosanganisira: Antibody conjugates (adss) adcs ine munhu anrcess anoziva zvakananga bundu-rakabatana antigen, akabatanidzwa nemushonga une simba. Kana iyo ADC inosungira kuchitokisi checancer, iri mukati, uye mushonga unoburitswa mukati mechitokisi, zvichitungamira kurufu rwesero. Muenzaniso uri Ado-trastuzumab Emtansine (Kadcyla) Izvo Zvinonongedzera Cancer Hwake Nekusungira ligands (mamorekuru anosunga kune vanogamuchira aya) kune vanobata zvinodhaka, zvinokwanisika kunongedza mushonga zvakananga kune aya ma cancer concer masero. Vaiti veRelous Receptors uye vanochinjisa Receptings vanowanzoitika zvinangwa [2] .Stimuli Izvi zvinovimbisa kuti mushonga unoburitswa chete paTumor saiti, kuderedza kure-chinangwa mhedzisiro. Mienzaniso inosanganisira kushandisa ph-inotyisa liposomes iyo inoburitsa para kubhadhara kwavo munzvimbo yeActic yeTumors [3] Targeted kutumira kwedhorobha. Izvi zvidiki zvidiki, zvinowanzoitika kubva ku1 kusvika ku100 Nanometers muhukuru, inogona kuunganidzwa kuti itakure zvinodhaka uye nekusarudza kuendesa kumasokisi cancer. Mhando dzakasiyana dzeNanoparticles inoshandiswa, imwe neimwe nezvigadzirwa zvayo zvakaringana: Losimes: Spherical vesolies yakaumbwa ye lipid bilayers, liposoms inogona kusimbisa ese maHydrophilic uye hydrophobic zvinodhaka. Polymeric Naneoparticles: Yakagadzirwa kubva kune biohandura polymers, aya nanoparticles inopa kudzoreredzwa zvinodzora zvinodhaka uye kusimudzirwa kugadzikana. Quantum Dots: Semiconductor nanocrystals ine akasiyana expical zvivakwa, Quantum Dots inogona kushandiswa yekufungidzira uye kutumira zvinodhaka. Kabhoni Nanotubes: Zvivakwa zveCylindrical zvakagadzirwa neCarbon Maatomu, kabhoni Nanotubes anogona kuve anoshanda neyekuvanzika ligands uye zvinodhaka.xamples yeanonongedzerwa zvinodhaka system Targeted kutumira kwedhorobha Systems parizvino iri mukushandiswa kwekiriniki kana kuvandudzwa: Doxil / caelyx: Liposomal doxorubicin, anotenderwa kurapwa kweecharongi yeOvarian, Kandi's Sarcoma, uye akawanda myeloma [4]. Yayo liposomal kuumbwa kunodzora cardiocoxicity kuenzaniswa netsika yechinyakare doxorubicin. Abraxane: Albumin-yakasungirirwa Paclitaxel, inoshandiswa kurapwa kwegomarara remazamu, isina-diki sero cancer, uye kenza yemapani [5]. Iyo Albumin inosungira inosungira kuendesa zvinodhaka kune iyo tumor site.challenges uye ramangwana dhaireprions Targeted kutumira kwedhorobha Inobata vimbiso huru, matambudziko akati wandei anosara: Tumor Heterogeneity: Cancer masero mukati mebunako anogona kuratidzira maitiro akasiyana, achiita kuti zviome kutaridzira masero ese zvinobudirira. Kudzikisira kwezvinodhaka: Masero cancer anogona kukudziridza kuramba kunonzwisisika kurapa nekufamba kwenguva. Dhirivhari zvipingamupinyi: Kusvika paTumor Site kunogona kuve kwakaoma nekuda kwezvipinganidzo zvepanyama, sekuti reropa-reropa. Kuyera-kumusoro uye kugadzira: Kugadzira zvakanangwa zvinodhaka zvinodhaka pane chiyero chakakura chinogona kuve chakaoma uye chinodhura.Future yekutsvaga kuedza kuri kutarisisa Kubatanidza zvakarongedzwa kurapa nedzimwe nzira dzekurapa, dzakadai sedzimbudzi. Kugadzira masisitimu ekukurudzira anokurudzira anokwanisa kuenderana neyekuchinja bundu microdentement. Kuvandudza Scalability uye Kubata-Kubudirira Kwekugadzira Yakanangwa Dhivha Dhivha Diki Systems.The Chiitiko cheShongong Baofa cancer Research Shandong baofa cancer researching Institute, isu tinoshingairira kuita nekutsvagisa nekusimudzira kwebhuku Targeted kutumira kwedhorobha masisitimu. Chikwata chedu chemasayendisiti nemheriniki vari kushanda kuti vakurire matambudziko ataurwa pamusoro apa uye kududzira kuvimbisa zvidzidziso mukushandisa maClinic. Isu tinotenda izvozvo Targeted kutumira kwedhorobha Irongwa hwakakosha hwekuvandudza cancer marongero emucheka uye nekuvandudza hupenyu hwehupenyu hwe cancer varwere.conclusiusesTargeted kutumira kwedhorobha inomiririra kufambira mberi kwakakura mu cancer kurapwa, kupa mukana wekuvandudza kushanda kwesimba uye kuderedza mhedzisiro. Nokusarudza kusarudza cancer masero, aya masisitimu anogona kuburitsa zvakakwirira zvekuvhundutsa zvinodhaka zvakananga kune bundu saiti, zvichitungamira kune zviri nani zvevarwere. Nepo matambudziko akasara, enderera mberi nekutsvaga nekuvandudza kuedza kuri kuita nzira yekubudirira kwegungano rakawanda uye rakarongeka..Refession National Cancer Institute - Anti Boy-drug conjugates Targeting Folate Receptor yeCancer Therapy Ph-inonyanyo liposomes yekurapa cancer. European Mishonga Agency - Doxil FDA - Abraxane Prescribing Information