kurapwa genetic mutation lung cancer kurapwa

Kurapa kwe genetic kuzvitunura mumapapu emapapu uye kurapa menderekedzo yemapapu muCancer Gwara iri rinopa kuongororwa kwakazara kweiyo genetic kuyedzwa mu cancer yemapapu, zviitiko zvizhinji, uye zvingashandiswa kurapwa. Iyo inovavarira kupa varwere uye mhuri dzavo nezivo inoda kufambisa rwendo urwu rwakaoma. Isu tichaongorora zvakarongedzwa kurapa, immunomunotherapy, uye mamwe marongero aripo mumachira emapapu emapapu anotungamirirwa ne genetic abnormalities.

Genetic kuyedza mu cancer yemapapu

Kukosha kwemanyorerwo

Usati watanga kurapwa genetic mutation lung cancer kurapwa, genetic kuyedzwa kwakakosha. Maitiro aya, anowanzotaurwa semanyorerwe emoleculing kana biomarker kuongororwa, anozivisa zvakananga genetic shanduko mukati mematumba masero. Aya mafambiro anogona kukanganisa sarudzo dzekurapa uye kufanotaura mukana wekupindurwa kwekurapa. Kuwanzoedzwa kuedzwa majini kunosanganisira EGF, ALK, Ros1, BrAF, uye KRA. Kuziva iyo chaiyo genetic mutation inobvumira Obcologists kuTailor kurapa kumanenjo yemurwere. Mhedzisiro yekuedzwa kweiyo genetic inokosha pakuona nzira yakanakisa yekuita.

Mhando dze genetic bvunzo

Nzira dzinoverengeka dziripo dzekuedza genetic, imwe neimwe nezvigadzirwa zvayo uye zvakashata. Izvi zvinosanganisira zvinotevera-chizvarwa kutevedzwa (ngs), izvo zvinobvumidza kuyedzwa panguva imwe chete marudzi mazhinji, uye polymerese keteni yekugadzirisa (pcr) Iyo sarudzo yenzira inoenderana nezvinhu zvakaita senge zviwanikwa zviripo uye mibvunzo yakatarwa yekiriniki iri kugadziriswa. Yako oncologist inokutungamira iwe kuburikidza neyakanakisa yekuyedza sarudzo kubva pane yako yemunhu mhosva.

Zvakajairika genetic kusetwa mu cancer yemapapu uye kurapwa kwavo

EGFR MUDZIMA

Egfr shanduro dzinozivikanwa mune dzisina-diki cell lung cancer (NSCLC), kunyanya muvarwere vasina kumboputa kana kuve nenhoroondo yechiedza kuputa. Taranied kurapa, senge egfr tyrosine kinase inhibitors (tkis), anoshanda zvakanyanya nevarwere nevarwere. Aya marators anovharira chiitiko cheiyo yakakwenenzverwa egfr protein, ichitadzisa kukura kwebundo. Mienzaniso inosanganisira Gishinib, Erlotinib, neAfatinib. Nekudaro, kuramba kune izvi zvinodhaka kunogona kutanga nekufamba kwenguva.

Alk rearransments

ALK rearrzarments ndeimwe yakakosha mutyairi mutya mutaundi mu nsclc. Zvakafanana neEnfr muchitunhi, ALK Rearrasements anowanzove neTKIS chaiyo. Criztinib neAlelecinib mienzaniso yeAlk Inhibitors yakave yakaratidza inoshanda mukurapa varwere neAlk-yakanaka mapapiro emapapu. Kugara uchiongorora kwakakosha kuziva uye kubata chero kupikisana kunogona kukura.

Ros1 rearransments

Ros1 rearransments haawanzo kudarika egfr kana alk yekugadzirisa, asi vanogovana kurapwa kwakafanana. Varwere vane ros1-yakanaka mapapiro cancer inogona kubatsirwa kubva pakurapa kwakanangidzirwa, senge crizotinib, lorlatinib, uye entrecebub. Aya marapirwo akaratidzira kubudirira mukuwedzera kupona uye nekuvandudza hupenyu hwehupenyu hwevarwere neiyi mutation.

Zvimwe Zvitatu

Dzimwe dzakasiyana-siyana menderekedzo dzezvidzidzo dzinogona kubatsira kumapapu eganza, kusanganisira braf, kras, uye kuzvitengesa kwaakasimba. Nepo tarisa maPoraphies aripo kune mamwe ekuzvishandura izvi, nzvimbo yekurapa iri kuramba ichiyerera, nekuenderera mberi kwekutsvaga sarudzo nyowani uye dzakavandudzwa. Iyo Shandong Baoma cancer Research Information Institute (https://www.bhabohanaleptal.com/) iri pamberi pekutsvagisa uku, kugara uchitsvaga sarudzo nyowani uye dzekuvhiringidza dzesarudzo dzekenza yemapapu.

Marongero ezvekurapa kupfuura anotarisa kurapwa

Immamuritherapy

Immamuritherapy inosunga simba remagetsi emurwere ekudzivirira kwemurwere kurwisa cancer. Cheki inhibitors, senge pombirolizumab uye nivolumab, inoshandiswa mukati kurapwa genetic mutation lung cancer kurapwa, dzimwe nguva mukubatanidzwa neanonongedzerwa kurapa kana chemotherapy. Aya mishonga inovharira maune cheki, ichibvumira immune system yekuziva zviri nani uye kurwisa cancer cancer masero. Immamuritherapy inogona kushanda kunyange mune zviitiko uko kwakanangidzirwa kurapa kunogona kusabatsira.

Chemotherapy

Chemotherapy inoramba iri yakakosha kurapwa sarudzo yegomarara remapapu, kunyanya mune dzakatarwa marongero kana kuti immunotherrapy haina kukodzera. Nekudaro, chemotherapy inowanzo kuve isina kunyanyovanzika pane kutsva mishonga yekurapa, uye inogona kuve nemhedzisiro yakakosha.

Radiation kurapwa

Radiation kurapwa kunogona kushandiswa kunongedza uye kuparadza cancer masero. Kazhinji inoshandiswa kudzikira tumors, kuderedza kurwadziwa, kana kuderedza zvimwe zviratidzo. Inogona kushandiswa yega kana kusanganiswa nezvimwe kurapa.

Kufambisa rwendo rwekurapa

Kurapa Type	Zvakanakira	Zvinokuvadza
Targeted kurapa	Kukwirisa kwakanyanya mune zvakanangana kuzvitunha, mashoma mhedzisiro pane chemotherapy.	Kupokana kunogona kukura, kusanyatsoshanda kuzvikoro zvese.
Immamuritherapy	Mhinduro dzakasimba, dzinogona kushanda kunyange nekupokana kune mamwe marapirwo.	Zvinogona kuitika kune zviitiko zvine chekuita nehanya.
Chemotherapy	Inoshanda mumhando dzakawanda dzekenza, iripo zvakanyanya.	Mimwe mhedzisiro inokanganisa pane yakanangidzirwa kurapa kana kuti immunomtherapy, isina kuvanzika kurapwa.

Kusarudza kodzero kurapwa genetic mutation lung cancer kurapwa Icho chiitiko chakaoma icho chinoda kubatana kwepedyo pakati pemurwere, yavo yeoni, uye dzimwe nyanzvi dzehutano. Izvo zvakakosha kubvunza mibvunzo, kunzwisisa sarudzo dzekurapa, uye kutora chikamu shangu mukuita sarudzo. Rangarira, kufambira mberi mukutsvaga zvinogara zvichinatsa marongero ekurapa ekenza yemapapu. Gara uchiziviswa, uye usazeza kutsvaga rutsigiro kubva kumapoka emurwere emurwere uye rutsigiro net.Discleer: Ruzivo urwu nderekudzidzisa chete uye harifanirwe kufungwa nezano rekurapa. Gara uchibvunza nezve nyanzvi yehutano kune chero hutano hutano kana usati waita chero sarudzo zvine chekuita nehutano kana kurapwa.