Kurapa kweRenal Cell Carcinoma: A Parthology maonero

Iyi gwara rakazara rinotsvaga iyo patelly yeRenal cell Carcinoma (RCC), ichinyengerera munzvimbo dzayo dzakasiyana siyana, dzinza nzira, uye zvizere nzira dzekurapa. Isu tinoongorora microscopic zvinhu, genetic shanduko, uye zvinhu zvinofemesa zvakabatana neRCC, tichipa kunzwisisa kwakadzama kwehutano hwehutano uye vatsvagiri.

Kunzwisisa Renal Cell Carcinoma

Tsanangura rcc uye yayo subtypes

Renal cell carcinoma, iyo inowanzoitika mhando yekona yeitsvo, inobva mukumirira kweiyo itsvo tubules. Dzakati wandei zvigaro zviripo, imwe neimwe ine zvakasiyana-siyana maitiro uye maitiro ekiriniki. Izvi zvinosanganisira cell cell rcc (ccrcc), papillary rcc (prcc), chromophobe rcc (chrcc), nevamwe. Kunyatsojeka kunokosha kutungamira Kurapa Renal Cell Carcinoma Pathology uye kufungidzira prognosis. Kugadziriswa chaiko kunovimba nekunyatsoongorora microscopic bvunzo uye immunohistochemical Staining, kazhinji inoda hunyanzvi muGenitourinary pategariro.

Microscopic zvinhu uye diagnostic maitiro

Iko kuongororwa kweRCC kwakanangana kubva kuFoptopathological kuongorora kwetishu sampuli inowanikwa kuburikidza ne biopsy kana yekuvhiya. Zvakanakisa microscopic maitiro, akadai se morphology, hunhu nyukireya, uye maitiro ekukura, batsira kusiyanisa pakati peRCC Subtypes. Semuenzaniso, CRCCC inoonekwa neCyToplasm, nepo Prcc inoratidza paPapillary architecture. Immunohistochemistry anotora basa rakakosha mukusimbisa kuongororwa uye kuzivisa zvakananga zvidiki, zvichibatsira kunatsa Kurapa Renal Cell Carcinoma Pathology zvirongwa.

Genetic kushandurwa uye molecular pathology

Basa reGenetics muRCC Development

Genetic Abnormalities anotamba basa rekusimudzira uye kufambira mberi kweRCC. Iyo inowanzoitika genetic shanduko inosanganisira iyo von hippel-lindau (vhl) tumor suppressor genge, kunyanya muCRCCC. Mamwe ma resini, akadai sePrb1, bap1, uye Setd2, anowanzoshandiswa zvakare mumashure akasiyana rcc. Kunzwisisa aya genetic kushandurwa kwakakosha kukudziridza kurapa kwakanangidzirwa uye kuvandudza zvibodzwa zvemurwere. Tekinoroji yeyakafambira mberi, seyinotevera-chizvarwa kuteverwa, vari kuwedzera kushandiswa kuona izvi zvekushandurwa, vachizivisa Kurapa Renal Cell Carcinoma Pathology nzira.

Zvekuita Zvekurapa Zvakarongedzwa

Iko kuzivikanwa kweiyo chaiyo genetic muutons muRCC yakatungamira mukuvandudzwa kweanonongerwa kurapwa. Semuenzaniso, inhibitors of vascular endothelial kukura chinhu (Vegf) uye mammali Aya vamiririri vakatarisana vanowanzoratidza kukosha kwekiriniki uye nekuvandudza huwandu hwekupona. Kutsvaga kuenderera mberi mumanyorerwo eRoleCar

Frognostic zvinhu uye marongero ekurapa

Kufanotaura prognosis uye kusarudzwa kwekurapa

Zvinhu zvinoverengeka zvinopesvedzera proong yeRCC, kusanganisira bundu rekutakura, giredhi, uye subtype. Kuvapo kwechirwere chesarthatiatic kwakanyanya kukanganisa kuponeswa kwemitengo. Pathological maficha, akadai segiredhi renyukireya uye necrosis, zvakare anopa mukurumbira kufungidzirwa. Izvi zvakadzama pathological ongororo yakakosha kutungamira sarudzo dzekurapa uye kuitisa mararamiro emumwe munhu. Kusarudzwa kwe Kurapa Renal Cell Carcinoma Pathology zvinoenderana zvakanyanya nekuongororwa uku.

Sarudzo dzekurapa uye yavo pathological hwaro

Maitiro ekurapa eRCC anosiyana zvichienderana nechikamu uye giredhi rechirwere. Kuzvishongedza kwekushata ndiko kurapwa kwekutanga kweanowanikwa RcC. Yemamhanje kana metastatic rcc, kurongeka kwezvirongwa senge zvevamiriri zvakanangwa kana kuti immunomtherapy anoshanda. Kusarudzwa kwekurapa kunowanzotungamirirwa neiyo patchological subtype, genetic shanduko, uye hutano hwemurwere. Kuenderera mberi kwekutsvaga kunoongorora nzira dzekutengesa dzinosimudzira, kuremedza kunzwisisika kwedu kwekuita ma molecular mechanisms kutyaira rcc kuvandudzwa kweRCC.

Advanced Tekiniki muRcc Pathology

Immunhuhistochemistry uye zvayo zvinoshandiswa

Immunohistochemistry (IHC) chishandiso chakakosha muRcc pathhology. Chaizvoizvo mamakisi, akadai seVHL, amacr, uye pax8, anoshandiswa kuona Rcc Subtypes uye kuvasiyanisa kubva kune mamwe madzinza emapundu. IHC inogona zvakare kubatsira mukuongorora tumor giredhi uye kufanotaura prognosis. Uyezve, IHC inoita basa rakakosha mukuzivisa vangangoita zvirongwa zvekuratidzira, kuratidza mwero Kurapa Renal Cell Carcinoma Pathology zvisarudzo.

MOLECARAR PATHOLOGY TUTNenique

Yepamusoro molecular maitiro, yakadai seinotevera-chizvarwa chekusarongeka NGS inobvumira kuti gadziriswe denthing genomic, ichizivisa huwandu hwakawanda hwekushandurwa kwemhando dzinogona kukanganisa kurapwa uye kufanotaura kurapwa. Hove dzinogona kuona zvakananga chromoomal abnormalities, kupa zvimwe zvinonzwisisika kuita tumor biology uye prognosis.

Ruzivo rwakapihwa pano ndezvekudzidzisa zvinangwa chete uye hazviite zano rekurapa. Kune kuongororwa uye kurapwa kweRenal cell Carcinoma, ndapota bvunza neanokodzera hutano hwehutano hwehutano.

Kuti uwane rumwe ruzivo uye rutsigiro, funga kushanya Shandong baofa cancer researching Institute webhusaiti. Ivo vanopa zvakakosha zviwanikwa uye hunyanzvi muCancer Care.