Phekotso e tsitsitseng ea kalafo ea lithethefatsi: Tataiso e felletseng 

Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi e emela tsoelo-pele ea bohlokoa ho saense ea meriana, e fana ka melemo e mengata ho feta mekhoa ea ho tsamaisa lithethefatsi tse tloaelehileng. Mokhoa ona o kenyelletsa ho etsa meriana ea bona ho lokolla metsoako ea bona e mafolofolo, e lebisang mekheng ea lithethefatsi tse tsitsitseng, e fokotsoeng khafetsa, le litla-morao li ka ba le litlamorao. Sengoliloeng sena se hlahloba melao-motheo, melemo, likopo le litaelo tsa bokamoso tsa ho phatloha ha lithethefatsi tse potlakileng, ho fana ka kakaretso e felletseng ea leano lena la bohlokoa la kalafo.

Kutloisiso e Kholisitsoeng Khatiso ea Lithethefatsi

Phekotso ea Lithethefatsi e Khobisitsoeng ea LithethefatsiHape, hape e tsejoa e le topollo e atolositsoeng kapa e laoloang, ke mokhoa oa tsamaiso ea lithethefatsi tse fetisang meriana ka nako e telele. Ho fapana le makhetlo a tokollong a ho lokolla kapele, a lokollang tekanyetso eohle hang-hang, litsamaisong tsa tokoloho tse kholisitsoeng li etselitsoe ho boloka maemo a lithethefatsi a kalafo bakeng sa nako e telele. Sena se fumaneha ka mekhoa e fapaneng ea ho theha e laolang sekhahla seo moriana o se nang moriti o tsoang foromo ea litekanyetso.

Melaoana ea tokollo e tšehelitsoeng

Molao-motheo oa Core Core Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi e bua ka sekhahla sa ho lokolla ha moriti ho fihlela profil e lakatsehang. Lintlha tse 'maloa li susumetsa tokollo ena, ho kenyelletsa:

• Lithethefatsi tsa Lithethefatsi: SHOELE, METSI ea Molecear le botsitso ba lithethefatsi.
• Moralo oa sebopeho: Mofuta oa polymer o sebelisitsoeng, sebopeho sa matrix le ho ba teng ha likokoanyana.
• Lintlha tsa 'Nete: PH ea mohlokomeli oa gastrointestinal, sekhahla sa ho loka le tšebetso ea enzymatic.

Ka ho nahana ka hloko, Bakhabulli ba Pharasiketsi ba ka raloa Khopolo e Khobisitsoeng Mefuta e ntlafatsang ho fana ka lithethefatsi le ho ntlafatsa sephetho sa kalafo. Bakeng sa temohisiso e khethehileng haholoanyane hore e se eka ho phekola li-affitli tsa mofets'e, ho hlahloba mekhoa ea lipatlisiso mabapi le mekhatlo e kang Shandong Baofa e ka fana ka moelelo o mong.

Melemo ea likhatiso tse matlafatsang

Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi e fana ka melemo e mengata ea bohlokoa e bapisoang le mekhoa e tloaelehileng ea lithethefatsi:

• Khafetsa ho fokotsa khafetsa: Bakuli ba sebelisa meriana ka tlase khafetsa, ho tlisa mekhoa e bonolo le ho khomarela.
• Maemo a lithethefatsi a tsitsitseng: E boloka mahloriso a sa fetoheng ea kalafo, fokotsa ho feto-fetoha ha ho feto-fetoha le litlamorao.
• Ho Ntlafatsa Mamello ea Mamello: Mekhahlelo e bonolo ea ho jala media e ntlafatsa kholingoang ka mamello ho meriana e laetsoeng.
• Litlamorao tse Fokotseng: Maemo a lithethefatsi a tsitsitseng a ka fokotsa likotsi tsa tlhoro tse tlatsetsang litlamorao tse mpe.

Mefuta ea lits'ebetso tse matlafatsang

Mahlale a 'maloa a fapaneng a hiriloe ho fihlela Khopolo e Khobisitsoeng. Mehlala e Tloaelehileng ke ena:

Matlapa a matrix

Matlapa a matrix a entsoe ka lithethefatsi ka har'a matrix ea polymer. Setlhare se lokollotsoe e le e beroes kapa moriana o tiisa matrix. Li-polymers tse tloaelehileng tse sebelisitsoeng:

• Pydrophilic Polymer: Hydroxypropypropypropinyl methylcelllulolose (HPMC), le polyethylene oxide (peo).
• Setsebi sa hydrophobic: Ethylxilose le Polymethacrylates.

Litsamaiso tsa Reservoir

Mekhoa ea pokello e nang le selepetsi sa lithethefatsi e pota-potiloe ke membrane ea nakoana. Setlhare se lokollotsoe ka har'a membrane sethaleng se reriloeng esale pele. Litsamaiso tsena li ka fana ka taolo e nepahetseng haholo holim'a tokollo ea lithethefatsi.

Litsamaiso tsa Osmotic

Tsamaiso ea osmotic sebelisa khatello ea lefutso ea ho laola khatello ea lithethefatsi. Letlapa hangata le na le membrane e lumelloang e nang le sekontiri se senyenyane. Ha metsi a kena ka matlatleng, e felisa moriana, 'me ho baka khatello ea khatello tharollo ea lithethefatsi ka sekoting se laoloang.

Li-microencap

Li-microencaps tse kenyelletsang ho kenyelletsa sethethefatsi ho microcapress kapa Microcapsules. Microcapsules tsena li ka kenngoa ka har'a tafole kapa capsule. Setlhare se lokollotsoe e le microcapsules e nyenyefatsang kapa sethethefatsi se tiisa ka leboteng la microcapUrune.

Likopo tsa Theknoloji ea ho lokolloa

Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi e sebelisoa libakeng tse fapaneng tsa libaka tsa kalafo, ho kenyelletsa:

• Tsamaiso ea bohloko: Bakeng sa maemo a bohloko a bohloko, li-opioids tse ileng tsa lokolla - lialgesion e seng li-ana e opioid li fana ka liphallelo tse tšoarellang nako e telele.
• Lefu la pelo: Khopolo e Khobisitsoeng Mefuta ea meriana e khahlanong le khatello ea maikutlo le khatello ea maikutlo le li-anti-barhystiki li thusa ho boloka khatello e tsitsitseng ea mali le morethetho oa pelo.
• Lefu la tsoekere: Khopolo e Khobisitsoeng Metformin ke kalafo e letsitseng la lefu la tsoekere ea mofuta oa 2, e fana ka taolo e ntle ea Glycemic.
• Bophelo bo botle ba kelello: Khopolo e Khobisitsoeng Antibepress le meriana ea khatello ea matšoenyeheng e ka ntlafatsoa ho latela litlamorao.
• ADHD: Khopolo e Khobisitsoeng Botsi ba khothatsana ba thusa ho ntlafatsa tsepamiso le ho ela hloko letsatsi lohle.

Mehlala ea Lithethefatsi tse Khothalelitsoeng

Lithethefatsi tse 'maloa Tse tsebahalang lia fumaneha ho Khopolo e Khobisitsoeng liforomo. Mehlala e 'maloa ke ena:

Liphephetso Khahlanong le Khokahano ea Khatiso e Kholisitsoeng

Ho hola hantle Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi LITLHAKISO li hlahisa mathata a mangata:

• Ho tsilatsila lithethefatsi: Ho netefatsa hore seriana se lula se tsitsitse har'a sebopeho ka mor'a nako.
• Bigavaimer: Ho boloka ho monya lithethefatsi ka mokhoa o lekaneng oa lithethefatsi le binavalilip.
• Dee oa lahla: Ho thibela ho se be le tse ling kapele ha moriana oa moriana.
• Ho rarahana ha ho rarahana: Ho hlaolela mekhoa e sa senyeheng le e theko e boima.

Mekhoa ea nako e tlang ho lokollotsoeng

Tšimo ea Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi e lula e fetoha lintho. Mekhoa e Meno e Tsoang:

• Medimo ya Botho: Ho tsamaisa Khopolo e Khobisitsoeng Mefuta ea ho bakuli ba nang le motho ka mong e thehiloeng ho lintlha tsa liphatsa tsa lefutso le tsa 'mele.
• 3D khatiso: Ho sebelisa theknoloji ea khatiso ea 3D ho theha tloaelo Khopolo e Khobisitsoeng liforomo tsa dosage.
• Smart Litsamaiso tsa Lithethefatsi: Litsamaiso tse ntseng li tsoela pele ho susumetsoa ke tšusumetso, tse kang pH kapa mocheso, ho tsosa tokollo ea lithethefatsi.
• Nanotechnology: Ho sebelisa nanoparts ho ntlafatsa phaello ea lithethefatsi le ho beoa.

Sephetho

Phekotso ea Lithethefatsi e Khobisitsoeng ea Lithethefatsi E fetotse tsamaiso ea lithethefatsi e fetotsoeng, e fana ka melemo e mengata ho bakuli le ba fanang ka bophelo bo botle. Ho tloha ho latela mamello ea mamello ho litlamorao tse fokotsehileng, Khopolo e Khobisitsoeng Mefuta ea ho bapala karolo ea bohlokoa ho kenya maemo a tloaelehileng a bongaka. Haholo-holo theknoloji e ntse e tsoela pele, re ka lebella hore re be le tsebo le ho feta ebile e sebetsa Khopolo e Khobisitsoeng Litsamaiso tsa ho hlaha nakong e tlang, ho matlafatsa sephetho sa mamello. Patlisiso e Iketseng Libakeng tse kang Shandong Baofa E totobatsa tsoelo-pele e tsoelang pele le bohlokoa ba kalafo e khethehileng le mekhoa ea ho fana ea lithethefatsi libakeng tse tebileng.

Dislaimer: Sengoliloeng sena se fana ka leseli ka kakaretso mabapi le kalafo ea lithethefatsi tsa kalafo ea lithethefatsi ebile ha ea lokela ho nahanisisoa ke bongaka. Kamehla buisana le setsebi sa bophelo bo tšoanelehang sa bophelo bo botle kapa pele ho lebaka le etsang liqeto tse amanang le leano la hau la kalafo.

Litšupiso: Tlhahisoleseling e fanoeng sehloohong sena e ipapisitse le lingoliloeng tsa sammuso tse fumanehang phatlalatsa le tlhaiso-leseling ea sehlahisoa sa PharmaCotucal. Lipalo tse ikhethang tsa data tse amanang le liforomo tse sebelisoang ho liwebosaete tsa phaello ea meriana tse mabapi le phaello e ntle ea meriana le ka tlhaiso-leseling ea sehlahisoa.