Unyango lwemfuza

Ukuqonda indima ye Unyango lwemfuza Kubalulekile ukuba ulawulo lwe-LART loMhlaza. Eli nqaku livavanya ukuba uluncedo lwemfuza luyakwazisa njani izigqibo zonyango, iindidi eziguqulweyo zifumaneka kwi-fistring ye-LIngs kwi-Counciang Umhlaza, kudla ngokuqhutywa ngu Unyango lwemfuza. Olu tshintsho lunokwenzeka kwimfuza elawula ukukhula kweseli, ukwahlula-hlula, nokulungiswa. Ukuchonga ezi zinguqu kubalulekile kuba kunokukhokela ngeendlela zonyango kunye nokuphucula iziphumo zomonde. Kwi-Bhandong BaeoF I-Baeoong Badrer Institute IZiko, sibeka phambili ukuqonda imeko yemfuza yomhlaza ngamnye wesigulana.Unyango lwemfuza ziinguqu kulandelelwano lwe-DNA olunokukhokelela ekuziphatheni ngeselfowuni. Olu tshintsho lunokufunyanwa njengelifa okanye lufunyenwe ngexesha lokuphila komntu. Kumhlaza wemiphunga, utshintsho olwenziweyo luxhaphake kwaye luhlala lubangelwa zizinto ezikhoyo zokusingqongileyo njengokutshaya okanye ukuvezwa kongcoliseko. Olu tshintsho lunokuphazamisa iinkqubo eziqhelekileyo zeselfowuni, ezikhokelela ekukhuleni okungalawulwa kunye nokuqulunqwa kwe-tuumurs.com yohlobo lwemfuza kwimiphunga yomhlaza we-LIGSEPE Ukuqonda olu tshintsho kubalulekile ekukhetheni indlela efanelekileyo yokunyanga. Nazi ezinye zezona zixhaphakileyo:I-EGFR (i-Epiradeli yokukhula kwe-Ecerider): Ukuguquguquka kwi-ENFR kuxhaphakile kumhlaza-weseli ongenzi omncinci (i-NSCLC), ngakumbi kwi-Adenocarcinomas. Olu tshintsho lunokwenza iiseli zomhlaza zinovelwano ngakumbi kwizifo ezithile ekugxilwe kuzo.I-Alk (Anaplastic Lymphoma Kinase): I-Alk Rearnesents yenye yenguqu ekujoliswe kuyo efumaneka kwi-NSCLC. I-Alk ethintela ibonakalise impumelelo enkulu ekunyangeni amathumba ngale nguqu.Ros1: Ukufana ne-alk, i-ros1 fusion inokuqhuba ukukhula komhlaza wephunga. I-Ros1 i-Inteithitoritors ziyafumaneka kwizigulana ezine-ros1 elungileyo ye-NSCLC.I-BRAF: Uguquko lwe-Braf, ngakumbi utshintsho lwe-V600E, luyafumaneka kwi-NSCLC. I-Braf i-inhibitors ingasetyenziselwa ukujolisa eziguquti.I-KRA: I-KRAS iguqukile kwi-lang adenocarcinova. Ngelixa imbali inzima ukujolisa, unyango olutsha luvela kwi-KRAS-Suled Imiphunga.I-PD-L1 (i-Wight-Ligand 1): Ngelixa i-gene iguqukayo ngokwesiko, intetho ye-PD-L1 yi-biomarker enokuthi icinge ngempendulo kwimmunotherapy. Ibinzana eliphezulu le-PD-L1 linokubonisa ukuba isigulana sinokungenelwa ngakumbi sizuze kuvavanyo lokuvavanywa.genenetic yomhlaza wemiphungaUnyango lwemfuza ichongiwe ngovavanyo lwemfuzo olubanzi lwemfuza, ekwabizwa ngokuba nguVavanyo lwe-biomarker okanye iprofayili ye-molecular. Olu nyango lovavanyo luhlalutyo lwethumba okanye, kwezinye iimeko, iisampulu zegazi zichonge utshintsho oluthile lwemvelo oluqhuba ukukhula komhlaza. Iziphumo zolu vavanyo zinceda oochwephesha be-oncologi ukwenza izicwangciso zonyango ukujolisa kwiimpawu ezizodwa zomhlaza ngamnye wesigulana. I-Beooooooo pha i-Bicer Institute isebenzise itekhnoloji yokuvavanya imeko yobugcisa ye-genetic.types zentlobo zovavanyo lwemfuza zeemvavanyo zemfuza zisetyenziswa kumhlaza womhlaza we-LIngS kunye noCwangciso loNyango:Ukulandelelana kwesibini (ii-NG): I-NGS yindlela ebanzi yovavanyo enokuhlalutya iintlobo ezininzi ngaxeshanye. Oku kuvumela ukufunyanwa koluhlu olubanzi lotshintsho kunye nolunye utshintsho lweze-NEZOIC.I-Polymerase Chain Rein Impendulo (PCR): I-PCR yeyona ndlela yovavanyo esetyenziswayo esetyenziselwa ukufumana utshintsho oluthile okanye izindlu zemfuza.I-Fluorescence kwi-HidGridation (intlanzi): Intlanzi isetyenziselwa ukufumana izindlu ze-gene, ezinjenge-alk kunye ne-ros1 fusions.I-Ignohistochemistry (IHC): IHC isetyenziselwa ukufumana intetho yeprotein, efana ne-PD-L1, enokunceda ekuqinisekisweni kwe-ismotherapy.Izwane novavanyo lwemfuza. Uvavanyo kufuneka lwenziwe kwangoko kwinkqubo yokucwangciswa konyango ukuze unyango olujolisiweyo lungaqwalaselwa kwasekuqaleni. Kubalulekile ukuba kuvavanywe kwakhona ukuba umhlaza okanye ukuba iinketho zonyango ezintsha zibekhona. Unyango lwemfuza. Olu nyango luyenzelwe ukuphazamisa ukukhula, ukwahlula-hlula, kunye nokusasazeka kweeseli zomhlaza ngelixa kuncitshiswa umonakalo kwiiseli eziqhelekileyo. Indlela ye-Beooo esibhedlele isebenzisa ezona ndlela ziphambili ze-Predies La machiza athintela umsebenzi weproteni ye-EGFR, ehlala isebenza kwiiseli zomhlaza ngezi zinguqulelo. I-Infithirs ePhente ye-EPFR ibandakanya:I-Gefinin (ipessa)I-ERLOTININB (TARCEVA)AfAtinib (i-gilotrif)I-Oshimitha (Tagrisso): Rhoqo unyango lodidi lokuqala lwe-EGFR-PredC.Alk ethinitalk Intenitors isetyenziselwa ukuphatha unomhlaza wemiphunga kunye ne-alk Rearings. La machiza athintela umsebenzi weproteni ye-ALK prothein, ehlala isebenza ngendlela engaqhelekanga kwiiseli zomhlaza ngezi zithuthi. I-Alk eqhelekileyo ye-alk ibandakanya:ICriizotinib (Xalkori)I-Aleccorinib (Alecenssa)ICertitinib (Zykadia)I-Brigatrib (Allrig)I-LORTATINB (i-LORBRENA)I-Ros1 I-Infithisorros1 i-inhibitors1 i-inhibitors1 isetyenziselwa ukuphatha unobangela wemiphunga kunye ne-ros1 fusions. La machiza athintela umsebenzi weproteyini ye-ros1, ehlala isebenza ngendlela engaqhelekanga kwiiseli zomhlaza ngale fusions. I-Ros1 i-Ros1 i-ros1 ibandakanya:ICriizotinib (Xalkori)I-TORDINBIB (ROZYYTRK)I-Braf ethinterbraf i-inhibitors isetyenziselwa ukuphatha unobangela wemiphunga ngokuguquka kwe-braf, ngakumbi iguquko le-v600e. La machiza athintela umsebenzi weprotein ye-braf, ehlala isebenza kwiiseli zomhlaza ngezi zinguqulelo. Iimpawu eziqhelekileyo ze-Braf zibandakanya:I-Dabrafenib (Taifinlar)I-Trametinib (Mekinist): Ihlala isetyenziswa ngokudibeneyo kunye ne-Dabrafenib.kras G1Sc I-Intanethi Basebenza ngokuthintela umsebenzi weeprotein ze-kras ze-kras.immunotherapy kunye nemveliso yemvelo yonyango luhlobo lonyango lomhlaza olwa nomhlaza womzimba olwenzeka. Ngelixa i-igonotherappy ayijongi ngqo Unyango lwemfuza, utshintsho oluthile lwendalo kunye nee-biomarmars, ezinjenge-PD-L1 intetho kunye ne-tumor ye-tumor (i-TMB), inokuxela kwangaphambili ngempendulo kwi-immunoherapy. Izigulana ezinentetho ephezulu ye-PD-L1 okanye i-idy ephezulu inokuba inokwenzeka ukuba ingenelwe kwi-immunotherapy. KwiZiko leMithombo yoNyango kunye nolunye unyango lwendlela ebanzi. Unyango olujolisiweyo olukhawulezileyo kunye nomonotherapies luyaphuhliswa kwaye luvavanywa kwiimvavanyo zeklinikhi. Abaphandi basebenza nokuchonga intsha Unyango lwemfuza Oko kunokuba lujolise kwimidaniso ye-noveli. Njengoko ukuqonda kwethu kwemitha yemiphunga yomhlaza wemiphunga kuphucuka, sinokulindela ukubona iindlela ezenziwe ngonyango kunye nezisebenzayo zonyango kwizigulana. IZiko loPhando lweShandong Baena lizibophelele ekuhlala phambili kubomi be-propitivescripructinognogriprikin, i-gefinib, i-gefinibb, ceritinib, rigatinib, rigatinib, I-LORTATINBGNGNGG ALK PROOSSEROSSEROSEALDEAGEAB, I-TORDINGINGINGNGNGNGNARG ROSGRAS G1PEINGE GODKRASIB, i-Adagrasibbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbblock iProtein Protein Prothenc i-KRASOCKANTION Unyango lwemfuza ibalulekile ekuphuculeni iziphumo kwizigulana ezinemihla yomhlaza wemiphunga. Uvavanyo lwemfuzo lunokunceda ekuguquleni utshintsho oluthile olunokujolise kunyango lomntu. Njengoko ukuqonda kwethu kwemfuza yomhlaza wemiphunga kuyaqhubeka ukukhula, sinokulindela ukubona unyango olusebenzayo nolujolisiweyo kwesi sifo esonakalisayo. Tyelelo IZiko loPhando lweShandong Baeo Ukuze ufunde ngakumbi malunga nendlela yethu epheleleyo yokhathalelo lomhlaza wemiphunga.Iphepha elichazayo: Olu lwazi luyinjongo lezemfundo kuphela kwaye akufuneki kuthathelwe ingqalelo icebiso lonyango. Soloko unxibelelana nengcali yezempilo efanelekileyo ukuze ufumane unyango kunye nokunyangwa kweemeko zonyango. www.cancer.govUmbutho woMhlaza waseMelika. www.cancerr.org