I-metastatic Prostrate yomhlaza

Umhlaza we-metastaticic Prostate prostate ngumhlaza onomhlaza osasazeke ngaphaya kwe-prostate gland iye kwamanye amalungu omzimba. Ukhetho lonyango luyahluka ngokuxhomekeke kubungakanani bokusasazeka, unyango lwangaphambili, kunye nempilo yempilo yesigulana. Unyango oluqhelekileyo luquka unyango lwehomoni, i-chemotherapy, i-Immunotherapy, kunye nonyango lwe-radiation. Unyango olutsha olufana noRadiapharphaceUuticals kunye neParp INibitors nayo iyasetyenziswa. IZiko loPhando lwe-Shandong Baena linikezelwe ukubonelela ngophando lokusika kunye nokukhethwa konyango ukuphucula iziphumo zesimo sengqondo. I-metastatitic prostate Umhlaza Xa isasazeka kwi-Grostate Gland ukuya kwezinye iindawo, uninzi lwamathambo, i-lymph node, isibindi kunye nemiphunga. Kubalulekile ukuqonda inqanaba kunye nenqanaba lomhlaza ukumisela olona kholo lubalaseleyo. Uxilongo ngokuqhelekileyo lubandakanya uvavanyo lokuvavanya njenge-Scans, i-CT Scans, kunye ne-Mnus, kunye nenkqubo ye-biopries. Utshintsho oluthile lwendalo kunye nezinto ezinxulumene ne-milving micronvevisveirove kule nkqubo. Inqaku le-gleason kunye nobukho bamabhayolothisi abathile nabo badlala indima ebalulekileyo ekuboniseni umngcipheko we-metastasis.standard iindlela zonyango ze-metastatic prostatic crestriepeeples ezisekwe I-metastatitic prostate Umhlaza. Oku kuhlala kusetyenziswa ngokudibeneyo okanye ngokulandelelana ukukhulula impumelelo. Oku kunokufezekiswa ngokulahla inkunkuma (Orchiectomy) okanye ukulinywa kwezonyango usebenzisa i-lhrh agonists okanye iintshaba. Iziphumo eziqhelekileyo eziqhelekileyo zibandakanya ukuqaqanjelwa okushushu, ukulahleka kwe-libido, ukungasebenzi kakuhle kwe-erectile, kunye nokudinwa. I-ADT ihlala iluncedo lomgca wokuqala I-metastatitic prostate UmhlazaI-.ChemotherapyChepyChemotheOtherapy iquka ukusetyenziswa kweziyobisi ukubulala iiseli zomhlaza. Ihlala isetyenziswa xa unyango lwehormone alusasebenzi (i-prostal enganyangekiyo i-Prostal-Crpc). Iziyobisi eziqhelekileyo ze-chemotheratherapy ezisetyenziselwa umhlaza we-prostate zibandakanya i-docetaxel kunye ne-cabazaxexe. Iziphumo ebezingalindelekanga zinokubandakanya isicaphucaphu, ukugabha, ukulahleka kweenwele, ukudinwa, kunye nomngcipheko owosulelekileyo wosulelo. IZiko loPhando lweShandong Baena ligxininisa iziphumo ebezingalindelekanga zokuphucula umgangatho wobomi.Radradiation Therapyradiation usebenzisa iiseli eziphezulu okanye amasuntswana ukubulala iiseli zomhlaza. Ingasetyenziselwa ukuphatha i-prostate ny (i-ractuation ye-ractuation ye-rachytheration okanye i-brachytherapy) okanye ekujolise kuzo iindawo ze-itastitatitic emathanjeni (i-radiation ye-radiation yangaphandle). Unyango lwe-radiation lonyango lunokunceda ukunciphisa iintlungu kunye nokuphucula umgangatho wobomi. Iziphumo ebezingalindelekanga zixhomekeke kwindawo ephathwayo kodwa inokubandakanya ukudinwa, ukucaphuka kwesikhumba, kunye neengxaki zentambo.urgergery, ezifana ne-prostatectomy, ayisebenzi kancinci I-metastatitic prostate Umhlaza. Nangona kunjalo, inokuqwalaselwa kwiimeko ezithile, njengokususa ithumba eliyintloko ukunciphisa iimpawu okanye ngokudibeneyo nolunye unyango. Ukususwa kokususwa kwezinto ze-metastatic kunqabile okwenziwe. I-metastatic Prostrate yomhlaza ihlala ivela, inika ithemba kwiziphumo eziphuculweyo nobomi obungcono. Nazi ezinye zeendlela ezintsha zendlela: I-radium-223 i-dabiguide (xofigo) yi-radiophaphaical esetyenziselwa ukuphatha i-bone metastases kwizigulana ezine-CRPC. I-Lutertium-177 Psma-617 yenye ye-radiaphanepharphacmation ejolise kwi-membrane ekhethekileyo (Psma), iprotein efumaneka kumphezulu weeseli zomhlaza. Iziphumo ebezingalindelekanga zinokubandakanya uxinzelelo lwe-bone marw kunye nokukhathazeka.immunopcopokimmunopy uhombiso lwamandla amajoni omzimba ukuze alwe nomhlaza. I-SIPULEUCL-T (icebo) lunyango olungwayo luvunyiwe kwi-Asymptomatic okanye i-CRPC ye-Crpc. Kubandakanya ukuqokelela amasele okhusela izigulana, ukulungisa ukuba baqonde iiseli zomhlaza, kwaye uze ubabuyisele kwisigulana. I-Pembromizumab, i-Intermating yokutshekisha, isenokuba yinketho yezigulana eziguqulweyo zohlobo oluthile okanye i-microsatellite ephezulu (MSI-H). I-Ibi-H). La machiza anokuphumelela kwizigulana ezinolwazi oluthile lwendalo, ezinje nge-brca1 / 2. I-Olaparib kunye ne-Rucaparib i-parp yokufaka evunyiweyo kunyango lwe-CRPC. Iziphumo eziqhelekileyo eziqhelekileyo zibandakanya i-anemia, ukudinwa, kunye nesicaphucaphu. IZiko loPhando lwe-Shandong Baena libandakanyeke ngenkuthalo kuphando ekwakhetha ukusetyenziswa kweParp ethinteration kunye nolunye unyango. Unokufunda ngakumbi malunga neParp ethintela kwi Iwebhusayithi yeZiko leSizwe leZiko.Ukuphindisela unyango oluhlangeneyo kusebenzisa iziyobisi ezijolise ngqo kwiimolekyuli ezithile ezichaphazelekayo ekukhuleni kweseli yomhlaza kunye nokusinda. Imizekelo ibandakanya iziyobisi ezithintela imiqondiso efana ne-PI3K / AKT / PREY YEYWA. Ezi ndlela zonyango zihlala zisetyenziswa kwizilingo zeklinikhi kwaye zisaphandwa ngokusebenza kwazo ekunyangeni I-metastatitic prostate UmhlazaIzicwangciso eziliqili zokuqina ngokusekwe kwinqanaba lesifo kunye nemibandela yomngcipheko ekukhetheni unyango ixhomekeke kwizinto ezininzi, kubandakanya nobungakanani besi sifo, impilo yezigulana, kunye nonyango. Le theyibhile ilandelayo ishwankathela iindlela zonyango ngokubanzi: Inqanaba / umngcipheko / umngcipheko wokukhetha i-Inmone-East Prestatic Prostate ADT + I-Androgen Retaitors (E-Abiraterone), i-enmalitheraple, okanye ityala lekliniki. I-Cacevatic-I-Cavatical Caretate Umhlaza (CRPC) I-Chemotherapy, i-Androgen Reopertors, i-AndrogerMermicmarmicutical, i-ranotherapyuticals, i-Ignotherapy, i-Parp ethinter (ukuba iyasebenza), okanye kuvavanyo lwekliniki. I-Bone metastaases radiation radiation, i-radiapharmicaluticals, i-bisphosphonates okanye i-denosumab (iiarhente zomeleza ithambo). Izilingo zeklinikhi kunye neemvavanyo zexesha elizayo zibalulekile ekuphuhliseni unyango olutsha noluphuculweyo lwe I-metastatitic prostate Umhlaza. Izigulana zinokuthatha inxaxheba ekuthabatheni kuvavanyo lweklinikhi ukufikelela kulawulo lokutsalwa kwemida kwaye babe negalelo kuphando lwezonyango. Uphando oluqhubekayo lujolise ekuphuhliseni unyango olujolise olusebenzayo, ulungelelwaniso kunye nonyango oludibeneyo. IZiko loPhando lwe-Shandong Baena lidlala indima ebalulekileyo ekuqhubeni uvavanyo lweklinikhi kunye nokuqhubela phambili intsimi yonyango lomhlaza. Unganxibelelana IZiko loPhando lweShandong Baeo Ngolwazi malunga nezilingo zeklinikhi yangoku kunye neendlela zonyango.liveretha nge-metastatic prostate ebhadisa nge I-metastatitic prostate Umhlaza Unokubonisa imiceli mngeni ebalulekileyo. Ukulawula iimpawu, ukujongana neziphumo ebezingalindelekanga, kwaye ukugcina umgangatho wobomi kubaluleke kakhulu. Amaqela enkxaso, ukucetyiswa, kunye neenkonzo zokhathalelo oluhlala kuzo zinokunika uncedo olubalulekileyo. Unxibelelwano oluvulekileyo nabanikezeli bezempilo lubalulekile ekwenzeni izigqibo ezinolwazi kunye nokufumana olona nyango lubalaseleyo I-metastatitic prostate Umhlaza Imeko enkulu, iindlela ezininzi zonyango ziyafumaneka ukunceda ukulawula esi sifo, ukuphucula umgangatho wobomi, kunye nokusinda. Ukuhlala unolwazi malunga nenkqubela phambili kunyango kwaye usebenza ngokusondeleyo neqela lezempilo lempilo kubalulekile ekwenzeni izigqibo ezinolwazi kunye nokufumana olona nyango lubalaseleyo. IZiko loPhando lwe-Shandong Baena uzibophelele ekuboneleleni ngononophelo olupheleleyo kunye nokuphucula intsimi yophando onomhlaza kunye nonyango.