Unyango olutsha oluncinci lweseli

Umhlaza omncinci we-Lings omncinci (i-NSCLC) ngunobangela ophambili wokusweleka komhlaza emhlabeni wonke. Ngethamsanqa, inkqubela phambili ebalulekileyo kwizinto zonyango ziyavela, zinika ithemba elitsha kwiziphumo eziphuculweyo kunye nomgangatho wobomi. Eli nqaku lifungela lakutshanje Unyango olutsha oluncinci lweseli, kubandakanya unyango olujolisiweyo, ama-gonotherapies, indibaniselwano ye-chemotheratherapy, kunye nokuvavanywa kweklinikhi ye-LIGS (i-NSCLC) ngowona mhlaza we-lings omncinci (i-NSCLC) ngo-80-85% yazo zonke iipesenti ezingama-80. Ibandakanya imithwalo emininzi, kubandakanya ne-adenocarcinoma, i-squamous carcinoma, kunye ne-carcinma enkulu. Inqanaba le-NSCLC ekufumaneni ifuthe kakhulu iindlela zonyango kunye ne-progunosis. Inqanaba lokuqala le-NSCLC linokunyangwa ngotyando, ngelixa amanqanaba aphezulu ahlala efuna indibaniselwano yamanyala. Ezi ndlela zonyango zihlala zisebenza ngakumbi kwaye zineziphumo ebezingalindelekanga ezimbalwa kune-chemotherapy yesiqhelo. Iithagethi eziqhelekileyo kwi-NSCLC zibandakanya i-EGRC, i-Alk, Ros1, i-BRAF, kwaye yadibana Abanye abantu be-NSCLC baneenguqulelo kwi-Gener, ekhokelela ekukhuleni kwesesi. I-EGFR ethintela, ezinjengeGifinib, i-ESfininib, AfAtidib, kunye ne-OSERTInib, ibhlokho ngomsebenzi we-ENFR, ukucothisa okanye ukuyeka ukhula.Izibonelelo: Ihlala isebenza kwizigulana eziguqukele kwi-ESFR, ekhokelela ekuphuculeni ukusinda kunye nomgangatho wobomi.Imiphumela: Ulusu lurhatya, urhudo, i-ditigue.simertinib ihlala iluncedo lonyango lwe-NSFR-owukhethileyo kwi-NSCLC ekhethekileyo, ebonisa ukusebenza okuphezulu kuthelekiswa nee-onfr ze-onfr. Unokufunda ngakumbi malunga ne-egr inhibitors evela kwi Iwebhusayithi ye-Americar Sociar.Alk inhibiticuristicy lymphoma kinase (i-alk) yenye iproteyini enokutshatiswa kwi-NSCLC. I-Alk tohitors, ezinjengeCriitinib, i-Criitinib, i-Brigatinib, ne-LORTATINB, ineeproteyini zeproteyini, ethintele umsebenzi wayo kwaye uthintele ukukhula kwethusi.Izibonelelo: Isebenza kwizigulana ezinama-Alk Rearnenges, ezikhokelela ekusindeni okuphuculweyo kunye nokuncitshiswa kwesifo.Imiphumela: Utshintsho lombono, isicaphucaphu, ukugabha, urhudo, ukudinwa.aletinib kwaye i-loretinib kunye ne-loretinib kwaye i-lorelatinib kwaye i-lottinib ihamba kakuhle igazi legazi, elibaluleke kakhulu kwizigulana. UPRANTRR TRAN UK Inika ulwazi olongezelelekileyo.ros1 I-Interithisms1 yi-Wallptor Typrosine Kingine Kinase yokuba, xa kuqengqeleka ngenye indlela enesiphelo, unokuqhuba ukukhula komhlaza. I-Ros1 i-Ithintelo, njengeCriizotinib kwaye isetyenziselwa ukunyanga i-NSCLC nge-ros1 fusions.Izibonelelo: I-tumor shrinkage kunye nokusinda ixesha elide kwizigulana ezine-ros1 elungileyo ye-NSCLC.Imiphumela: Ukufana ne-Alk ethinter.Xtatninib ibonakalisile isithembiso ngenxa yokukwazi kwayo ukuwela umqobo-wobuchopho, owenza ukuba isebenze ngokunyanga i-metastase yengqondo. Jonga IWebhusayithi ye-Arhente yaseYurophu yaseYurophu Ngolwazi oluneenkcukacha I-Ibiotion yendawo yokugcina izilwanyana iluhlobo lonyango olubonisa iiproteni ezithintela iproteni yeseli yeseli yeseli. I-PD-1 / PD-L1 ethintela, ezinje ngePembarolimab, iNivolomab, i-DITZONIZUMAMAMAMAMAMAMAMAMAMAMARAB, EDursbumab, ibhlokhi le proteni, ivumela iiseli zomhlaza.Izibonelelo: Iimpendulo ezomeleleyo kunye nokusinda okuphuculweyo kwiseti yezigulana nge-NSCLC.Imiphumela: Iziphumo ebezingaphelelanga ezinxulumene neziphumo, ezinjenge-pumonitis, i-colitis, kunye neHepatitis.pembromizumab ihlala isetyenziswa njengonyango lomgca wokuqala we-NSCLC ngentetho ephezulu ye-PD-L1. Ulwazi oluninzi lunokufumaneka kwi Iwebhusayithi ye-FDAIproteli ye-T-4 inhibitithi-4 inhibitithioctoocyte T-I-T-Lymphocyte T protein 4 (CTLA-4) yenye iproteyini enokucinezela amajoni omzimba. Iplimundab yi-CTLA-4 inhibitor engasetyenziswanga ngokudibeneyo kunye ne-PD-1 inhibitors yokuphucula impendulo yomkhuselo nxamnye neeseli zomhlaza.Izibonelelo: Ingaphucula ukusinda xa idityaniswa ne-PD-1 inhibitotors.Imiphumela: Iziphumo ezibalulekileyo ezingapheliyo ezinxulumene neziphumo ezinxulumene ne-PD-1 inhibitors yedwa.Chemotherapy Indiagetwwile ejolise kunyango, i-chemotherapies ihamba inketho ebalulekileyo, ngakumbi ngokudibeneyo nolunye unyango. Unyango olutsha oluncinci lweseli Ihlala ibandakanya ukudibanisa i-chemotherapy okanye i-unyango ekujoliswe kulo ukuphucula ukusebenza kwazo.ChemommunoMnobsombing chemotherapy nge-funotherapy ibonisa iziphumo ezithembisayo Unyango olutsha oluncinci lweseli. Le ndlela ifumana amandla e-chemotherapy yokunyanga ukonakalisa iiseli zomhlaza kwaye ikhuphe i-adobrins, ibenze bachaphazeleke ngakumbi ekuhlaseleni iziqhamo. Ukongezwa kwemmunotherapy kunokukhuthaza impendulo yomzimba, ekhokelela kwiziphumo eziphuculweyo.Izibonelelo: Ukuphuculwa kwexabiso lokuphuculwa kunye nexabiso lokuphendula xa kuthelekiswa neChemotherapy yodwa.Imiphumela: Ukunyuka komngcipheko wokuhamba kwe-chemotherapy kunye neziphumo ebezingalindelekanga ezinxulumene nonyango kunye ne-chemotherapy kunye ne-chemotherapy iimeko ezithile, ngakumbi kwizigulana eziphuhlileyo kunyango olujolise kunyango olujolisiyo lodwa. Le ndlela inokukunceda ngeendlela zokungaxhasi kunye nokuphucula iziphumo zonyango.Izibonelelo: Ungayibuyisela ubuntununtunu kunyango olujolise kulo kwaye uphucule ukusinda.Imiphumela: Umngcipheko osindileyo weziphumo ebezivela kuzo zombini iindlela zonyango.clines: Ikamva lovavanyo lonyango lwe-NSCLC luphando lwezifundo ezivavanyayo Unyango olutsha oluncinci lweseli kunye nezicwangciso-qhinga. Ukuthatha inxaxheba kwityala leklinikhi kunokubonelela ngokufikelela kwiindlela zokucheba ezinqamlezileyo ezingekafumaneki ngokubanzi. IZiko loPhando lweShandong Baena bazibophelela ekuqhubeni uphando lomhlaza kwaye babonelela ngeenkonzo kwaye bathathe inxaxheba kwizilingo zeklinikhi ezibonelela ngolawulo lomphetho ongekabikho. Funda ngakumbi malunga novavanyo lweklinikhi kwi-Shandong BaeoF yoPhononongo loPhandoI-charpies ethengisayo kwiKlinikhi yeKlinikhi iyathembisa Unyango olutsha oluncinci lweseli ngoku ivavanywa kwiimvavanyo zeklinikhi, kubandakanya:I-Antictor-Iyobisi leziyobisi (ADCs): La machiza ahambisa i-chemotherapy ngqo kwiiseli zomhlaza, ukunciphisa umonakalo kwiiseli ezisempilweni.I-Bispecific Antibodies: Ezi antibodies zibopha kuzo zombini iiseli zomhlaza kunye neeseli zokhuselo, zizisa kunye ukonyusa impendulo yomzimba.I-Plok Porapies (E.G., Unyango lwe-car-t sel): Olu lontlalontle lubandakanya ukuguqula amasele ukhuselo ukujolisa kwaye utshabalalise iiseli zomhlaza.Ngaba ne-NSCLC: Cinga ngokuhlola izixhobo kwimibutho efana ne Umbutho waseMelika okanye Isiseko seLunguvity.Iphepha elichazayo: Eli nqaku lenzelwe ulwazi kuphela kuphela kwaye akufuneki lithathelwe ingqalelo icebiso ngonyango. Nceda unxibelelane nomboneleli wakho wezempilo kwizincomo zonyango.