Ukuhanjiswa kweziyobisi evelayo kuMhlaza: Isikhokelo esibanzi 

Ukuhanjiswa kweziyobisi ezikwindawo yomhlaza yindlela yokuziphatha egxile kumayeza ngokuthe ngqo kwindawo yethumba. Le ndlela ijolise ekuphuculeni ukusebenza ngonyango ngelixa inciphisa iziphumo ezisecaleni zenkqubo ehambelana ne-chemotherapy yemveli.

INTSHAYELELO UKUZONWABISA NGOKUGQIBELA

Unyango lwe-domboric onjengela i-chemotherapy luhlala lubandakanya ulawulo lweSpotinel, kuthetha ukuba amayeza ahamba kuwo wonke umzimba. Ngelixa isebenza kakuhle ekujoliseleni iiseli zomhlaza, le ndlela inokwenzakalisa iiseli ezisempilweni, ezikhokelela kwiziphumo ebezibalulekile. Ukuhanjiswa kweziyobisi Inika inkqubo ekujoliswe kuyo ngakumbi, ukuhambisa amayeza ngokuthe ngqo kwindawo ye-tumor.

Le ndlela inokubandakanya iindlela ezahlukeneyo, kubandakanya:

• Ngqo kwinaliti yeziyobisi kwituma.
• Ukubekwa kweempukane ze-Ekling zeziyobisi okanye ii-wafr.
• Ukusetyenziswa kwe-nanopalicals ekujoliswe kuyo ukuze uhambise iziyobisi ngokuthe ngqo kwiiseli zomhlaza.
• I-chemotherapy yengingqi, apho amachiza aqhutywa kwindawo ethile yomzimba equkethe ithumba.

Izibonelelo zokuhanjiswa kweziyobisi

Ukuhanjiswa kweziyobisi inika izibonelelo ezininzi eziphambili kubanquli benkqubo:

• Iziphumo ezizezimali ezivaliweyo: Ngokugxininisa ichiza kwindawo ye-tumor, ukuveza izicubu ezinempilo kuyancitshiswa, kukhokelela kwiziphumo ezimbalwa nezingaphantsi kakhulu.
• Ukwanda kweziyobisi kwi-tumor: Ukuhanjiswa kwendawo kunokufezekisa ukugxininisa iziyobisi okuphezulu ngaphakathi kwe-tuma, okunokwenzeka ukuphucula ukusebenza ngonyango.
• Ukuphuculwa kwesigulana sobomi bethu: Iziphumo ezichaphazelekayo neziphumo zonyango zinokuphucula kakhulu umgangatho wobomi bomguli ngexesha lomhlaza.
• Inokubakho kunyango lweendidi: Ukuhanjiswa kwendawo kungadityaniswa nolunye unyango, njengokuhlishwa, unyango lwe-radiation, kunye ne-chemotherapy ye-chemotherapy, ukufezekisa imiphumo yobudlelwane.

Iindlela zobuchule bokuhanjiswa kweziyobisi

Iindlela ezininzi zisetyenziselwa Ukuhanjiswa kweziyobisi, nganye inezibonelelo zayo kunye nokusikelwa umda:

Ngqo kwinaliti

Oku kubandakanya ngokuthe ngqo ichiza kwi-tumor. Yindlela elula nengabizi kakhulu ilungele amathumba afikelelekayo. Isikhokelo se-ultrasound okanye isikhokelo se-CT sinokusetyenziselwa ukuqinisekisa ukubekwa ngokuchanekileyo. Imizekelo ibandakanya inaliti yeentsholongwane okanye ii-chemotheutic agents.

Ukufakwa kwezixhobo zeziyobisi kunye ne-wafirs

Ezi zixhobo zifakwe ngokuthe ngqo kwi-tumar okanye kufutshane netuma. Bakhupha ichiza kancinci kancinci, babonelela ngesiphumo sonyango oluzinzileyo. Gliadel^? I-WEBS, ene-carmustine (BCnu), ngumzekelo owaziwayo osetyenziswa emva kokuphathwa kwamathumba obuchopho.

I-nanoparclecles

I-nanopalicles ngamasuntswana amancinci ayilelwe ukuhambisa iziyobisi ngokuthe ngqo kwiiseli zomhlaza. Banokuhlawulelwa ukujolisa kumameva athile kwiiseli zomhlaza weeseli, ukuphucula ukuqokelelwa kweziyobisi kwindawo yethumba kunye nokunciphisa iziphumo ekujoliswe kuzo. I-LIOSOMES, iPolymeric Nanopalicles, kunye ne-Nanopalicals ze-nanopalicles zisetyenziswa rhoqo.

I-chemotherapy yengingqi

Oku kubandakanya ukuhambisa amachiza e-chemotherapy ukuya kwindawo ethile yomzimba equkethe ithumba. Imizekelo ibandakanya:

• I-hepatic yobugcisa (hai): Isetyenziselwa ukunyanga umhlaza we-LILR ngokuhambisa i-chemotherapy ngqo kwisibindi ngokusebenzisa ubugcisa be-hepatic.
• Intraperitoneal chemotherapy (IP): Isetyenziselwa ukuphatha umhlaza we-ovaric ngokuhambisa i-chemotherapy ngqo kwi-abdomual cavity.
• I-Limb Pefsion (i-IlP): Isetyenziselwa ukuphatha i-hulanoma kunye ne-sarcoma yemilenze ngokuzazisa ukujikeleza kwe-limb kunye nokuhambisa iidosi ze-chemotherapy ngqo kwindawo echaphazelekayo.

Imizekelo yokuhanjiswa kweziyobisi evelweyo kunyango lomhlaza

Ukuhanjiswa kweziyobisi isetyenziswa kunyango lweentlobo ezahlukeneyo zomhlaza. Nantsi imizekelo embalwa:

Amathumba obuchopho

Gliadel^? I-WEBS ifakwe kwingqondo emva kokususwa kwe-subniomas ephezulu. Ezi zafis zikhuphe i-carmustine (BCnu), iyeza le-chemotherapy ichiza, ngqo kwi-suvical cavity, ibulala naziphi na iiseli zomhlaza osele. Isifundo esapapashwa kwi-Narjenali ye-Oncology ye-Oncology * ibonakalise ukuba i-gliadel^? I-WEBENZISHIKELELE IXESHA LOKUQHUTYELWA KWI-PROOCIL ASINOKUFUMANEKA KWI-GLIASMAS EPIGE EZIQHELEKILEYO.¹

Umhlaza weSibindi

I-hepatic yobugcisa Kubandakanya ukuhambisa iziyobisi zokunyanga i-chemotherapy ngqo kwisibindi ngokusebenzisa ubugcisa be-hepatic, esona nqanawa iphambili igazi ibonelela isibindi. Oku kuvumela ukugxininisa okuphezulu kweziyobisi ukufikelela kwithumba ngelixa kunciphisa iziphumo ebezingalindelekanga. Izifundo zibonise ukuba i-HAI inokuphucula ukusinda kwizigulana ezinomhlaza wesibindi esingathethekiyo. Iingcali kwi IZiko loPhando lweShandong Baeo Sebenzisa kakhulu obu buchule.

Umhlaza we-ovarian

Intraperitoneal chemotherapy (IP) yindlela ye-chemotherapy yengingqi esetyenziselwa ukuphatha umhlaza we-ovarian. Kubandakanya ukuhambisa iziyobisi zokunyanga i-chemotherapy ngqo kwisisu esiswini, apho umhlaza we-Ovarian uhlala usasazeka. Oku kuvumela ukugxininiswa okuphezulu kweziyobisi ukufikelela kwiiseli zomhlaza esiswini. Izifundo zibonakalise ukuba i-IP Chemotherapy inokuphucula ukusinda kwizigulana ezine-ovarian of Avarian.

Imiceli mngeni kunye nezikhokelo ezizayo

Ngelixa Ukuhanjiswa kweziyobisi Inika izibonelelo ezininzi, kukho imiceli mngeni yokwahlula:

• I-tumor heterogeneity: Iiseli zomhlaza ngaphakathi kwesitulo zinokuba zahluke ngokwemvelo, zenza kube nzima ukujolisa kuzo zonke iiseli ngokufanelekileyo.
• Ukuxhathiswa ngamachiza: Iiseli zomhlaza zinokuhlakulela ukumelana neziyobisi ze-chemotherapy, zinciphisa ukusebenza kwempumelelo ekuhanjisweni kwendawo.
• Izithintelo zokuHambisa: Amanye amathumba kunzima ukufikelela okanye izithintelo zomzimba ezithintela iziyobisi ukuba zingafikeleli kuzo zonke iiseli zomhlaza.
• Imirhumo yemveliso kunye nokulawula: Ukuphuhliswa kwemveliso yokufumana iziyobisi ezifakwe kwiziyobisi kunokuba nzima kwaye kube neendleko.

Uphando lwexesha elizayo lujolise ekusombululeni le mingeni ngo:

• Ukuphuhliswa kwamacebo okujolisa ngakumbi ukuze woyise i-tumor heterogeneity.
• Ukudibanisa ukuhanjiswa kweziyobisi kunye nolunye unyango, njengokuhamba ngembonakalo kunye nonyango olujolise ekunyangeni ngamachiza.
• Ukuphuhlisa iinkqubo ezintsha zokuhambisa iziyobisi ezinokungena ngempumelelo.
• Ukulungelelanisa iinkqubo zokwenza imveliso kunye nokulawulwa kweenkqubo zokuhambisa iziyobisi.

Ukuqukumbela

Ukuhanjiswa kweziyobisi Yindlela ethembisayo enokuphucula ukusebenza kakuhle konyango kwaye inciphise iziphumo ebezingalindelekanga. Njengoko uphando luyaqhubeka, le ndlela inokuthi idlale indima ebaluleke ngakumbi kunyango lomhlaza. Ngokujolisa ngqo neziyobisi kwi-tumoor indawo, ukuhanjiswa kwendawo kunokunikela ithemba elitsha kwizigulana ezilwa nesi sifo esonakalisayo.

Uluhlu lwemibuzo

Izalathiso

1. Westphal, M., H. C., Bortey, E., Del Mastro, R. Isigaba se-3 solingo se-chemotherapy yendawo ene-bigustine ye-biloupers (i-BCnu) (BCnu) (BCnu) (BCnu) (BCnu) (BCnu) (BCnu) (BCnu) * Ijenali yeKlinikhi yeKliniki *, * 21 * (24), 44141919.