Ukukhutshwa okuzinzileyo kweziyobisi ngonyango: Isikhokelo esibanzi 

Ukukhutshwa okuzinzileyo kweziyobisi imele ukuqhubela phambili okukhulu kwisayensi yamayeza, ukubonelela izibonelelo ezininzi kwiindlela eziqhelekileyo zokuhanjiswa kweziyobisi. Le ndlela ibandakanya ukuqulunqa amayeza okukhulula izithako zawo ezisebenzayo ngokuthe ngcembe ngaphezulu kwexesha elongeziweyo, ekhokelela ekuguqukeni iziyobisi ezongeziweyo emzimbeni, kuncitshiswa rhoqo, kwaye okunokubakho iziphumo ebezingalindelekanga. Eli nqaku lichonga imigaqo, izibonelelo, izicelo, kunye nezikhombisi ezizayo zokuzibophelela iziyobisi, ukubonelela ngesishwankathelo esibanzi sesi sicwangciso sonyango esibalulekileyo.

Ukuqonda ukukhululwa iziyobisi

Ukukhutshwa okuzinzileyo kweziyobisi, ekwabizwa ngokuba kukhululwa okwandisiweyo okanye ukukhululwa, yindlela yolawulo lweziyobisi ekhupha amayeza emzimbeni ngokuthe ngcembe ixesha elide. Ngokungafaniyo nefom yokukhupha kwangoko, ethi ikhuphe yonke idosi ngeenkqubo zange kwaoko, iinkqubo ezinzileyo zenzelwe ukugcina amanqanaba eziyobisi ngonyango ngexesha elide. Oku kufezekiswa ngeendlela ezahlukeneyo zokwakha ezilawula ireyithi ekhutshwayo kwifom yedosi.

Imigaqo yokukhululwa okuzinzileyo

Umgaqo ophambili Ukukhutshwa okuzinzileyo kweziyobisi Ubuxoki bokudibanisa inqanaba lokukhutshwa kweziyobisi ukufezekisa iprofayili yonyango oyifunayo. Izinto ezininzi zikuphepha ukukhululwa, kubandakanya:

• Iipropathi zeziyobisi: Ukuluka, ubunzima bemoleya, kunye nozinzo lwamachiza.
• Uyilo lweNkqubo: Uhlobo lwePolymer esetyenzisiweyo, ulwakhiwo lweMatrix, kunye nobukho bamatyala.
• Izinto zesoftware: I-ph ye-gestrointenal phecana, ireyithi ye-gistric apting, kunye nomsebenzi obonakalayo.

Ngokuzibandakanya ngononophelo ezi zinto, izazinzulu zamayeza zinokuyila Ukukhutshwa okuzinzileyo Ifomula ezokwandisa ukuhanjiswa kweziyobisi kwaye iphucule iziphumo zonyango. Ngeenkcukacha ezikhethekileyo ezikhethekileyo kubanquli bomhlaza omhlaza umda, ukuphonononga amanyathelo ophando kumaziko anje IZiko loPhando lweShandong Baeo inokubonelela ngemeko engaphezulu.

Izibonelelo zefomu yokukhutshwa okuzinzileyo

Ukukhutshwa okuzinzileyo kweziyobisi Inika izibonelelo ezininzi eziphambili xa zithelekiswa neendlela eziqhelekileyo zokuhanjiswa kweziyobisi:

• Ukucuthwa kwe-Dossing Dolly: Izigulana zithatha amayeza kancinane, ukuphucula lula ngokufanelekileyo kunye nokubambelela.
• Inqanaba elinokuzinza iziyobisi ngakumbi: Gcina uxinzelelo olungaguqukiyo lonyango, ukunciphisa ukuguquguquka kunye neziphumo ebezingalindelekanga.
• Ukuphuculwa kwesigulana sokuthotyelwa: Irejimeni ye-Doung elula yomeleza ukubambelela ngomonde kumayeza amiselweyo.
• Iziphumo ezizezimali ezivaliweyo: Inqanaba leziyobisi elizinzileyo linokunciphisa uxinzelelo lwe-piak enegalelo kwiziphumo ezibi.

Iindidi zeenkqubo zokuthumela ezizinzileyo

Iitekhnoloji ezahlukeneyo ezahlukeneyo ziqeshwa ukufezekisa Ukukhutshwa okuzinzileyo. Nantsi imizekelo eqhelekileyo:

Iitafile zeMatrix

Iitafile zeMatrix ziqulunqwe ngesiyobisi esisasazeke kwi-polymer matrix. Ichiza likhutshwa njenge-matrix erodes okanye ichiza liyahluka kwi-matrix. I-polymers eqhelekileyo isetyenziswa:

• I-Hydrophilic Polymers: Hydroxypropyl methylcelcellulose (i-HPMC), kunye nePolythylene oxide (POO).
• I-Hydrophobic Polymers: I-Ethylcellulose, kunye nePolymethacylates.

Iinkqubo ze-reservoir

Iinkqubo zokugcina indawo ziquka isiseko seziyobisi ezijikelezwe yi-membrane yokulawula. Ichiza likhululwa kwi-membrane kwinqanaba elimiselweyo. Ezi nkqubo zinokubonelela ngolawulo oluqinisekileyo kakhulu malunga nokukhululwa kwamachiza.

Iinkqubo ze-OSMOIC

Inkqubo ye-OSMOIC isebenzisa uxinzelelo lwe-osmotic ukulawula ukukhutshwa ngamachiza. Ithebhulethi iqhele ine-membrane efikayo ngomngxunya omncinci. Njengamanzi angena kwithebhulethi, ayinyibilikisa ichiza, kunye noxinzelelo lwe-OSmoithi anyanzela isisombululo seziyobisi ngaphandle komngxunya kwinqanaba elilawulayo.

I-microncappamps

I-microncaPPS ibandakanya ukuchaza ichiza ngaphakathi kwemikrithi encinci okanye imicrocapssules. Ezi Microcaps zinokufakwa kwithebhulethi okanye kwi-capsule. Ichiza likhutshwa njengoko i-microcapsules ihlupheke okanye ichiza lingahlukanga ngodonga lwe-microcapsule.

Izicelo zeTekhnoloji yokukhutshwa kwezityalo

Ukukhutshwa okuzinzileyo kweziyobisi isetyenziswa kuluhlu olubanzi lweendawo zonyango, kubandakanya:

• Ulawulo lweentlungu: Kwiintlungu ezingapheliyo, ii-opioids ezigcinakileyo kunye nee-opioid ze-opioid zibonelela ngoncedo lwentlungu ende.
• Isifo seentliziyo: Ukukhutshwa okuzinzileyo Ifomula yamayeza okulwa i-anti-hyperteest kunye ne-anti-verhythmics inceda ukugcina uxinzelelo lwegazi oluzinzileyo kunye nesingqisho sentliziyo.
• Iswekile: Ukukhutshwa okuzinzileyo I-Metiforn liyeza eliqhelekileyo lohlobo lwesifo seswekile 2, ukubonelela ngolawulo olungcono lwe-glycemic.
• Impilo Yengqondo: Ukukhutshwa okuzinzileyo I-antidepressunts kunye namayeza oxinzelelo alwa nexhala anokuphucula ukubambelela kunyango kwaye unciphise iziphumo ebezingalindelekanga.
• I-ADHD: Ukukhutshwa okuzinzileyo Iziphakamiso zinceda ukuphucula ukugxila kwaye kuthathelwe ingqalelo imini yonke.

Imizekelo yeZiyobisi eziZinzileyo

Amachiza aliqela awaziwayo ayafumaneka Ukukhutshwa okuzinzileyo Ifomula. Nantsi imizekelo embalwa:

Imiceli mngeni kuphuhliso oluzinzileyo

Ukuhlakulela ukusebenza Ukukhutshwa okuzinzileyo kweziyobisi Ifomula ifaka imiceli mngeni emininzi:

• Uzinzo lweziyobisi: Ukuqinisekisa ukuba amachiza ahlala esinzile ngaphakathi kokuqulunqwa kwexesha.
• I-Bioaaaiff: Ukugcina ukufunwa ngamachiza okwaneleyo kwi-bioaas.
• I-Dose ilahla: Ukuthintela ukukhululwa okukhawulezayo kwechiza.
• Ubunzima beMveliso: Ukuhlakulela iinkqubo ezincomekayo kunye nexabiso lendleko zokwenza iindleko.

Iindlela zexesha elizayo zokukhululwa okuzinzileyo

Intsimi ye Ukukhutshwa okuzinzileyo kweziyobisi ihlala ivela. Iindlela ezivelayo zibandakanya:

• IIMALI YOKUGQIBELA: Ukulungelelanisa Ukukhutshwa okuzinzileyo Ukwenziwa kwiimfuno zomguli ngamnye ngokusekwe kwizinto zemvelo nezamzimba.
• I-3D Printa: Sebenzisa itekhnoloji ye-3D yokwenza ngokwezifiso Ukukhutshwa okuzinzileyo Iifom zedosi.
• Iinkqubo zokuHanjiswa kweziyobisi ze-Smart: Ukuphuhlisa iinkqubo eziphendulayo kwi-stimuli ethile, efana ne-pH okanye iqondo lokushisa, ukukhulula ukukhutshwa ngamachiza.
• I-nanotechnology: Sebenzisa i-nanopalicals ukonyusa ukuhanjiswa kweziyobisi kunye nokujolisa.

Ukuqukumbela

Ukukhutshwa okuzinzileyo kweziyobisi Unolawulo oluguqukayo iziyobisi, ukubonelela ngeengenelo ezininzi kwizigulana kunye nabanikezeli bezempilo. Ukusuka ekuphuculeni ukuthotyelwa kwezigulana okuphuculweyo ukuze kuncitshiswe iziphumo ebezingalindelekanga, Ukukhutshwa okuzinzileyo Ifomula idlala indima ebalulekileyo ekulawuleni uluhlu olubanzi lweemeko zonyango. Njengoko itekhnoloji iyaqhubeka ukuqhubela phambili, sinokulindela ngakumbi ngakumbi kwaye isebenza Ukukhutshwa okuzinzileyo iinkqubo zokuvela kwikamva, ngakumbi ukuphuculwa kwesigulana. Uphando olunikezelweyo kwiindawo ezinje IZiko loPhando lweShandong Baeo igxininisa phambili phambili phambili phambili phambili kunye nokubaluleka konyango olukhethekileyo kunye neendlela zokunikwa kweziyobisi kwiindawo ezinobuchule zezempilo.

Iphepha elichazayo: Eli nqaku libonelela ngolwazi ngokubanzi malunga nokukhutshwa kwezisombululo ezinzileyo iziyobisi kwaye akufuneki kuthathelwe ingqalelo iingcebiso zonyango. Soloko unxibelelana nengcali yezempilo efanelekileyo kuyo nayiphi na inkxalabo yezempilo okanye ngaphambi kokwenza naziphi na izigqibo ezinxulumene nesicwangciso sakho sonyango.

Izalathiso: Ulwazi olunikezwe kweli nqaku lusekwe kuncwadi olusesidlangalaleni kunye nolwazi lwemveliso yamayeza. Iiparamitha zedatha ezithile ezinxulumene nokwenziwa kwamachiza zinokufumaneka kwiiwebhusayithi zenkampani ezichaphazelekayo kunye nemveliso echaza ulwazi.