Unyango lweseli elincinci lomhlaza

Umhlaza-weseli ongenzi mncinci weseli (i-NSCLC) luhlobo oluqhelekileyo lomhlaza wemiphunga. Ukhetho lonyango lwe-NSCLC luhluka kwaye luxhomekeke kwizinto ezininzi, kubandakanya inqanaba lomhlaza, impilo epheleleyo yesigulana, kunye notshintsho oluthile lwendalo ngaphakathi kwesitulo. Esi sikhokelo sinika isishwankathelo sendlela ephambili ye-NSCLC, isuka kwi-sundouration ye-radiation yokuhlakulela unyango kunye nokuxhobisa abaguli kunye nabanonohloli kunye nolwazi lokwenza izigqibo ezinolwazi.Umhlaza-weseli ongenzi mncinci weseli (i-NSCLC) liqela leentsinga zemiphunga eziziphatha ngendlela efanayo. Iindidi eziphambili ze-NSCLC zibandakanya i-Adenocarcinoma, i-squamous carcinoma, kunye ne-carkoma enkulu. Ukuxilongwa ngokuchanekileyo, kubandakanya nokuvavanywa kwezinto kunye nokuvavanywa kwe-molerm, kubalulekile ukuba kuchongwe esona sicwangciso sonyango. IZiko loPhando lweShandong Baena linikezelwe kuphando lomhlaza kwaye kuphuhliso lweendlela ezintsha zonyango, funda ngakumbi kwi https //baofital.comI-AsclCNSCLC isetyenziswe ngokusebenzisa inkqubo ye-TNM (i-tuma, i-node, i-metastasis). Inqanaba lichaza ubungakanani kunye nendawo ye-tumoor ephambili, nokuba umhlaza uye wasasazeka kwiindawo ezikufuphi (n), nokuba umhlaza uye wangena kwizakhiwo ezikude (m). Uluhlu lwenqanaba ukusuka kwi (kwinqanaba lokuqala) kwi-IV (iNqanaba eliPhambili) Ezi biomarmars zinokunceda ukumisela ukuba isigulana singumgqatswa weendlela ekujoliswe kuzo. Uguquko oluqhelekileyo lubandakanya i-EGFR, ALK, ROS1, i-BRAF, kunye nabanye. Iziphumo zokuvavanywa kwemolekyuli kwiimpembelelo zonyango .standard Unyango lwe-NSCLCI-surgerysisgery ihlala ilunyango lokuqala kwi-NSCLC ye-NSCLC (i-II). Injongo kukususa ithumba kunye neendawo ezikufuphi ne-lymph. Iindidi zotyando zibandakanya: I-Wedge Rection: Ukususwa kwesiqwengana esincinci, sedge -dge-speed semiphunga. I-Segmertectomy: Ukususwa kwenxalenye enkulu yomphunga kunenkqubo ye-Wedge. Lobectomy: Ukususwa kwe-lobe yonke yemiphunga. Le yeyona nkqubo ixhaphakileyo ye-NSCLC. I-Pneumonectomy: Ukususwa komphunga wonke. Oku kuncinci kwaye kugcinwe i-sumopyraudraudition engaphezulu ye-sumopyradiation isebenzisa iyeza eliphezulu lamandla ukubulala iiseli zomhlaza. Ingasetyenziswa njengonyango oluphambili, emva kotyando lokubulala nayiphi na iiseli zomhlaza osele, okanye ukunciphisa iimpawu (i-palliative radiation). Iindidi ezahlukeneyo zonyango lwe-radiation ibandakanya: I-radiation ye-radiation ye-Biam yangaphandle (i-EBRT): Imitha inikezelwa kumatshini ngaphandle komzimba. I-Sterereotactic yomzimba we-radiation radiation (SBRT): Ihambisa iidosi eziphezulu ze-radiation kwindawo encinci, efanelekileyo. Ihlala isetyenziselwa i-NSCLC ye-NSCLC xa utyando ayisiyo inketho. I-Brachytherapy (i-radiation yangaphakathi ye-radiation): Izinto zerediyo zibekwe ngaphakathi kwi-tumor okanye kufutshane ne-It.ChemotherapyCheOpCherapy isebenzisa iziyobisi ukuba zibulale iiseli zomhlaza kuwo wonke umzimba. Ihlala isetyenziswa ngokudibeneyo notyando okanye i-radiation pady, okanye njengonyango oluphambili I-NSCLC. Iziyobisi eziqhelekileyo ze-chemotheratherapy ye-NSCPPEC iquka i-pisplatin, i-carboplaplatin, paclimaXel, i-Docetaxel, i-Pemetaxied, kunye neGemcitabine.Teargeed Unyango lwe-NSCLCUnyango olujolisiweyo ziziyobisi ezijolise kwiimolekyuli ezithile ezichaphazelekayo ekuhlululeni kweseli yomhlaza nokusinda. Ezi ndlela zonyango zisebenza kuphela ukuba i-tumar iguqukile okanye i-proby yeprofayili yeprofayili yeprofayili. I-NSCLC kunye nokuguqulwa kwe-inger. La machiza athintela iproteni ye-EGFR, enceda iiseli zomhlaza zikhule. Imizekelo ibandakanya: I-Gefininib (i-Iscta) i-Everlotinib (Tarceva) Afutinib (Gilotrif) Oshimitha (i-Taprisso) i-almphoma Kinitors isetyenziselwa ukunyanga I-NSCLC kunye ne-alk generesses. La machiza athintela iprotein Alk, enceda iiseli zomhlaza zikhule. Imizekelo ibandakanya: ICriizotinib (Xykadia) I-Alectinib (i-Zykadia) i-rigatrinib (i-Alecenssa) i-rigatrib (i-Alecenssa) i-I-rigatrinib (i-Alecenssa) i-lorblatinib (i-Archrig) i-ITolatinib (i-Lorbrena) i-Ros1 i-Infithirs I-NSCLC nge-ges1 ye-ros. La machiza athintela iproteyini ye-ros, enceda iiseli zomhlaza zikhule. Imizekelo ibandakanya: ICriizotinib (Xalkori) I-EntsgenIn I-NSCLC ngotshintsho lwe-braf v600e. La machiza athintela iproteyini ye-braf. Imizekelo ibandakanya: Dabrafenib (Tafinlar) I-Trametinib (Mefinist) (esetyenziselwa ukudityaniswa kunye ne-DABRAFINB) Ezinye izinto ezijolise kunyango olujolise kuguquko olubekiweyo kwi-tuma. Imizekelo ibandakanya i-tohitors (kwi-fungelo i-fungelo) kwaye idibane no-inhibitors (kwi-Ton-Stping Stpings) .immunotherapy Unyango lwe-NSCLCIziyobisi zokunyanga zinceda amajoni omzimba alwa nomhlaza. Basebenza ngokuthintela iiproteni ezithintela amajoni omzimba ekuhlaseleni iiseli zomhlaza. Ezi zihlala zisebenzisa I-NSCLC Unyango.pd-1 / PD-L1 INithitorsPD-1 Imizekelo ibandakanya: I-Pembromizumab (I-Indintrida) i-Nivoolizab (Opdivo) I-Temin-4 i-I-Infinzi) I-Temiplimab inkqubo yomzimba. Umzekelo nguMzekelo (Yervoy), uhlala usetyenziswa ngokudibeneyo kunye ne-PD-1 inhibitors.Cobbing Pioblesting, Unyango lwe-NSCLC kubandakanya ukudityaniswa konyango ezahlukeneyo. Umzekelo, utyando lunokulandelwa yi-chemotherapy okanye i-radiation thapy. Unyango olujolisiweyo okanye i-immunotherapy inokudityaniswa ne-chemotherapy. Umdibaniso othile uya kuxhomekeka kwimeko yomntu ngamnye. Ukufumanisa ngakumbi malunga notyelelo lophando lomhlaza IZiko loPhando lweShandong Baeo. Iimvavanyo zemvavanyo zemvavanyi zeZifundo zophando ezivavanya unyango okanye ukudityaniswa konyango. Abaguli I-NSCLC Ingathatha ukuthatha inxaxheba kwiimvavanyo zeklinikhi ukufikelela kulawulo lokucheba. Ulwazi malunga nezilingo zeklinikhi lunokufumaneka kwiwebhusayithi yeZiko loNcedo lweZiko leZiko leZiko kunye neminye imithombo ephikisayo Unyango lwe-NSCLC inokubangela iziphumo ebezingalindelekanga. Kubalulekile ukuxoxa ngeziphumo ezinokubakho kunye nogqirha wakho kwaye ufunde ukubalawula njani. Unonophelo lwenkxaso, njengokulawulwa kwentlungu kunye nenkxaso yesondlo, kunokunceda ukuphucula umgangatho wobomi ngexesha lonyango.prognosis kunye nokulandela i-prognosis I-NSCLC Kuxhomekeka kwinqanaba lomhlaza, impilo enkenenkene, kunye nendlela umhlaza uphendula ngayo unyango. Ukuqeshwa rhoqo okulandelayo kubalulekile ukubeka esweni ukuphinda ujonge kwaye ulawule naliphi na iziphumo ebezingalindelekanga zonyango.Iphepha elichazayo: Eli nqaku libonelela ngolwazi ngokubanzi malunga Unyango olungelulo lweseli olungenasincinci (i-NSCLC) kwaye akufuneki ukuba ithathwe njengengcebiso yonyango. Soloko unxibelelana nogqirha wakho okanye ezinye izinto ezenziwe ngezempilo eziqeqeshiweyo zezempilo kwizindululo zobuqu malunga nemeko yakho yonyango.