Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs

Inkqubela phambili yonyango kwimidlalo yaselusuni yomhlaza we-Lungs kwi-Ingstorsures eSisibekiso esisigxina kwimiphunga yemiphunga iyavela ngokukhawuleza, inika ithemba elitsha kwizigulana. Eli nqaku lifungela imigudu yakutshanje Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs, egxile kwiindlela ezinobudlelo, ukuphuculwa kwezixhobo zokuxilonga, kunye nokhathalelo lwesigulana. Siza kuhlolisisa inkqubela phambili ephambili kunye neziphumo zabo zokuphucula iziphumo zesigulana.

Unyango olujolise kulo

Ukuguqula unyango lomhlaza

Unyango olujolisiweyo lubonisa ukuqhubela phambili okukhulu ngaphakathi Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs. Olu nyango lujolise kwiimolekyuli ezithile kwiiseli zohlaza, ukunciphisa umonakalo kwizicubu ezinempilo. Imizekelo iquka ii-tyrosine ze-tyrosine inhibitors (i-TKIS), ekujoliswe kuzo kujongwa ngokukhula komhlaza we-lang. Ukusebenza kwe-TKIS kuyahluka ngokuxhomekeke kuguquko oluthile, kuqaqambisa ukubaluleka kweyeza elenzelwe wena kwinkathalo yomhlaza wemiphunga. Obunye uphando luyaqhubeka ngokujonga iithagethi ezintsha kwaye luphuhlise amachiza asebenzayo. Ukuchaneka kwezi ndlela kukhokelela ekusebenzeni ngokuphuculweyo kunye neziphumo ezininzi eziphezulu ngokuthelekiswa ne-chemotherapy yesiqhelo.

I-gonotherapy

Ukucheba izikhuselo zomzimba

Umgono uvele njengomdlalo otshintsha umdlalo kumlo wokulwa nomhlaza wemiphunga. Olu nyango lunyusa amajoni omzimba omzimba ahlasele iiseli zomhlaza. Ukujonga izinto zokujonga, uhlobo lwemmunotherapy, iiproteni zebhlokhi ezithintela amajoni omzimba ekuqondeni nasekutshabalaliseni iiseli zomhlaza. Oku kuvumela amajoni omzimba ukuze ajolise ngokuphumelelayo kwaye aphelise iiseli zomhlaza. Ngelixa i-igonoperapy isebenza kakhulu kwezinye izigulana, kubalulekile ukuqondakalisa ukuba ayizizo zonke izigulana eziphendulayo ngokulinganayo. Iimvavanyo eziqhubekayo zeklinikhi ziphonononge indibaniselwano eyahlukeneyo yemmunoherapies kunye nonyango olujolise kwiziphumo zonyango. Ekhokelayo Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs, Uvavanyo olungqongqo luchaza eyona khosi yonyango izigulana.

Inkqubela phambili ekuxilongeni

Ukufunyanwa kwangoko kunye nonyango olwenziwe ngumntu

Ukuphuculwa kweendlela zokuqonda zokuxilonga zidlala indima ebalulekileyo ekuphuculeni izigulo. Inkqubela phambili ekucingeleni itekhnoloji ye-CT-Dose CT ye-CT ivumela ukuba kufunyanwe umhlaza wemiphunga, ukuphucula amathuba onyango oluyimpumelelo. I-biopsies yolwelo, indlela encinci engenabuncinci yokufumana i-DNA yomhlaza kwiisampulu zegazi, yenza ukuba iqhubekeke ukuqhubela phambili isifo segazi kunye nempendulo yonyango. Ezi zicelo zinokuphucula ubuchule boxinzelelo obuqu ezenziwa kwimpawu ezithile zemfuza zethumba lesigulana ngalinye. Ukwanda kwawo kunye nokufumaneka kwezi teknoloji zifaka kakhulu igalelo elikhulu Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs.

Utyando oluncinci kakhulu

I-Humouma elingaphantsi, ukubuyisela ngokukhawuleza

Iindlela zokuhlaselwa ngamandla angahlaseli amancinci, ezinje ngotyando-utyando lwe-daricic oncedisiweyo we-vieric (VAT), bano utyando lomhlaza we-LIV. Le nkqubo ibandakanya isimilo esincinci, esikhokelela kwiintlungu ezincinci, inciphise ilahleko yegazi, ukuhlala isibhedlele esifutshane, kunye namaxesha okubuyisela ngokukhawuleza kwizigulana. Xa kuthelekiswa notyando oluvulekileyo, i-VAT ibonelela izibonelelo ezibalulekileyo ngelixa ugcina ukusebenza ngokuphumelela kwi-tumoor. Ukwamkelwa kwerobhothi kuhlelo lokuphucula ukongeza ngokuchanekileyo kwaye kunciphise ukungavisisani. Oku kunegalelo elikhulu kumgangatho wobomi ophuculweyo kwizigulana eziphantsi koqhaqho lomhlaza wemiphunga kwi Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs.

Unonophelo lwenkxaso

Ukuphucula umgangatho wobomi bobomi

Inkathalo ebanzi yokuxhasa ibalulekile ekomelezeni impilo-ntle yezigulana zomhlaza. Oku kubandakanya ulawulo lweentlungu, inkxaso yesondlo, ukuCetyiswa kwengqondo, kunye neenkonzo zokuvuselela. Inkathalo ehlangatyelweyo iphucula umgangatho wobomi ngexesha nasemva konyango. Uninzi luqhubele phambili Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs Nikeza amaqela anikezelweyo anikezelweyo ukubonelela ngononophelo lwezigulana. La maqela asebenza ngokusondeleyo nabahlohli bezonyango, oogqirha, kunye nezinye iingcali ukuqinisekisa ukuba abaguli bafumana inkxaso ebanzi abayifunayo.

Izikhombisi ezizayo

Uphando oluqhubekayo nophuhliso

Uphando kunyango lomhlaza i-LIVS uqhubeka ukukhawulezisa. Izazinzulu ziphonononge unyango oluhle, njengeentsholongwane ezi-oncolytic kunye nonyango lwemoto yemoto, ukujolisa kwiiseli zomhlaza ngaphezulu. Ukuphuhliswa kokukhetha ngakumbi kunye nokungabi namachiza angaphantsi kwetyhefu kuhlala kuyinto ephambili. Iyeza elomeleleyo, elikhokelwa yi-proiling proiling, iqinisekisa ukuba unyango lulungiselelwe iimfuno zabaguli nganye, lukhulisa ukusebenza kwabo nokunciphisa iziphumo ebezingalindelekanga. Ikamva le Inkqubela phambili yonyango kwizibhedlele zoCwangciso lweMings Lungs Ubuxoki kwintengiso eqhubekayo kunye neenzame zentsebenziswano kuzo zoqeqesho lwenzululwazi.

Uhlobo lonyango	Izibonelelo	Ukungancedi
Unyango olujolise kunyango	Ukuchaneka okuphezulu, iziphumo ebezingalindelekanga	Ayisebenzi kulo lonke utshintsho, elinokubakho ukunyangwa ngamachiza
I-gonotherapy	Iziphumo ezidlulileyo ezihlala ixesha elide, zinokubakho kwiimpendulo ezomeleleyo	Ayisebenzi kuzo zonke izigulana, ezinokubakho kwiziphumo ezibi kakhulu
Utyando oluncinci kakhulu	Intlungu encinci, ukubuyela ngokukhawuleza, ukuhlala isibhedlele esifutshane	Isenokungafaneleki kuzo zonke izigulana okanye iintlobo zethumba

Ngolwazi oluthe kratya malunga nonyango olugqibeleleyo lomhlaza wemiphunga, unokuphonononga izibonelelo njengeziko leZiko leSizwe leSizwe (https: //www.cancer.gov/) Kwaye cinga ngokunxibelelana neZiko eliPhezulu lomhlaza elinjenge IZiko loPhando lweShandong Baeo kwingcebiso eyakhe yabakho.