Ukukhutshwa konyango lokukhutshwa kweziyobisi

Ukukhutshwa okulawulwa kweziyobisi: ISikhokelo seSikhokelo seSikhokelo seSikhokelo seZiyobisi zenzelwe ukwenzela ukukhutshwa kweearhente zonyango, ukubonelela ngokuvezwa kweziyobisi. Le ndlela inika izibonelelo ezibalulekileyo kwiindlela eziqhelekileyo zokuhanjiswa kweziyobisi ngokwenza umsebenzi wokuphumelelayo kunye nokunciphisa iziphumo ezibi. Eli nqaku libonisa iinkalo ezahlukeneyo ze Ukukhutshwa konyango lokukhutshwa kweziyobisi, eqhayisa itekhnoloji eyahlukileyo, izicelo, kunye nezikhokelo ezizayo.

Iindidi zeenkqubo zokukhutshwa kweziyobisi

Iinkqubo zeMatrix

Iinkqubo zeMatrix zibandakanya ichiza ngaphakathi kwi-polymeric matrix elawula izinga lokukhupha. Indlela yokukhutshwa isenokuba yeyokusebenza, elawulwa yi-erosion, okanye indibaniselwano yabo bobabini. Umzekelo, iipolids ezinobungozi njenge-polylactic-vlycolic acid (PLGA) isetyenziswa rhoqo kwezi nkqubo, ukuhambisa ukonakaliswa kweziyobisi ixesha elide. I-kinetics ekhuphayo inokulungelelaniswa ngokutshintsha iipropathi zePolymer, ukulayisha iziyobisi, kunye nejometri yesixhobo.

Iinkqubo ze-reservoir

Inkqubo yokugcina i-reservoir isebenza ngechiza ngaphakathi kwesiseko, esijikelezwe yi-membrane yokulawula umlinganiso. I-membrane ilawula izinga lezilolo zeziyobisi ukusuka kwi-resevili kwindawo engqongileyo. Ezi nkqubo zihlala zibonelela ngeprofayili yokukhupha okungapheliyo xa kuthelekiswa neenkqubo zeMatrix. Imizekelo ibandakanya iimpompo ze-osmotic kunye neetafile ze-membrane.

Iinkqubo ze-bioerodid

Iinkqubo ze-bioerodishes zisebenzisa i-polymers ezikhupha okanye zichume ngokuhamba kwexesha, ukukhulula ichiza elinencasa. Ixabiso lokukhukuliseka libeka iprofayili yokukhupha. Itekhnoloji iluncedo ngakumbi kwizicelo ezifuna ukuhanjiswa kweziyobisi ixesha elide, njengokwezixhobo ezifanelekileyo. Ii-biompatid ne-polymers ezinokubonakala kwaye zifana nezo zisetyenziswa kwiiNkqubo zeMatrix ezazikhankanywe ngaphambili, zibalulekile kolu hlobo lwe Ukukhutshwa konyango lokukhutshwa kweziyobisi.

Iinkqubo zokuphendula eziphendulayo

Iinkqubo eziphendulayo ezikhuthazayo zikhupha ichiza ekuphenduleni kwi-Stimuli engaphandle, ezinje ngotshintsho kwi-PH, ubushushu, okanye ubukho bee-enzymes ezithile. Le ndlela yokujolisa kugxilwe kuyo inokuphucula ngakumbi ukusebenza kunye nokunciphisa iziphumo ebezingalindelekanga. Uphando kule ndawo lusenza ngenkuthalo izixhobo ze-Ivel kunye neenkqubo.

Izicelo zokuhanjiswa kweziyobisi

Ukukhutshwa konyango lokukhutshwa kweziyobisi Fumana isicelo ngokubanzi kwiindawo ezahlukeneyo zonyango. Eminye imizekelo ephawuleka ibandakanya: Unyango lomhlaza: Iinkqubo zokuthumela ezilawulwayo zinokuhambisa iiarhente ze-chemotheutic ngqo kwiisayithi zethumba, zinciphise ityhefu yenkqubo. Le ndlela ibaluleke ngokukodwa ekunciphiseni iziphumo ebezingalindelekanga ezinzima zihlala zinxulunyaniswa ne-chemotherapy. I-HORMONUP YOKUGQIBELA I-HORMONOPER YOKUGQIBELA: Iinkqubo zokukhutshwa ezilawulwayo zisetyenziswa kakhulu kwi-hormone yonyango, ukubonelela ngamanqanaba e-hormone kunye nokuthintela ukuguquguquka okunokukhokelela kwimiphumo engafunekiyo. I-Opioid Paint Counter: Ifomu yokukhupha i-opioid yee-opioids ivumela ukukhululeka kwentlungu eyandisiweyo, ukunciphisa isidingo se-dosing rhoqo kunye nokunciphisa umngcipheko wobukhoboka. Unyango olusulelekileyo: ii-antibiotics kunye nee-antiviorals zinokuxhamla kwifomu elawulwayo yokukhuthaza ukubonakaliswa kweziyobisi ixesha elide kwindawo yosulelo.

Izibonelelo kunye nokungalunganga kokuhanjiswa kweziyobisi

| Inzuzo | Ukungasebenzi ||---------------------------------------------------- Ukuphuculwa kwesigulana esiphuculweyo | Inokubakho ukukhululwa okokuqala || Ukuncitshiswa rhoqo kwe-dosing | Ukuveza kobunzima kunye nexabiso || Ukuphuculwa kokufanelekileyo Ubunzima bokuxela kwangaphambili iiprofayili zexesha elide || Iziphumo ezinciphiselweyo | Ulawulo olunqongophele ukukhulula i-kinetics ekhuphayo kwiimeko ezithile || Inqanaba leziyobisi ezinzileyo | Imiba enokubakho nge-biompatision |

Imikhombandlela yexesha elizayo ekunikezelweni kweziyobisi

Uphando oluqhubekayo lugxile ekuphuhliseni iinkqubo eziphezulu zolawulo kunye nezinto eziphuculweyo zokusebenza, kubandakanya: i-nanotechnology: Ukusetyenziswa kwe-nanomaticy: Ukusetyenziswa kwe-nanomaticy: Ukusetyenziswa kwe-nanomatials ukuyila iinkqubo ekugxilwe kuzo iziyobisi kunye ne-finetics ephuculweyo. I-Bioprine Ubukrelekrele be-AFTIFFIT: Ukusetyenziswa kwe-AI ukuphucula uyilo kunye nolawulo lweeprofayili zokukhululwa ngaphakathi Ukukhutshwa konyango lokukhutshwa kweziyobisi Iinkqubo.I-shandong baook¹ Kungaphambili lophando kunye nophuhliso kwiindlela ezintsha zolawulo lomhlaza, kubandakanya iinkqubo zokuhambisa iziyobisi. Ukuhlolwa kophando lolwazi lwetekhnoloji yohlelo olukhethekileyo uthembisa inkqubela phambili ebalulekileyo kukhathalelo lwezigulana kunye neziphumo zonyango.¹ IZiko loPhando lweShandong Baeo. [https:///12/3 )/1: