unyango olungeDLULEKILEYO lweSungs Iseli

Ukukhetha unyango lweScle yomhlaza weLwimi (i-NSCLC) Ukuqonda unomhlaza ongenamncinci weseli kunye nenqaku elifumanekayo ngonyango olunika ulwazi olubanzi malunga nonyango olungelulo lwe-LIGS. Sikhangela iindlela ezahlukeneyo zonyango, kubandakanya utyando, i-chemotherapy, unyango lwe-radiation, kunye nonyango olujolisiweyo, kunye nonyango olujongileyo, oluchaza ukusebenza kwabo kunye neziphumo ebezingalindelekanga. Sijonge ekuxhobiseni abantu abajamelene nokuchonga ngolwazi ngolwazi ukuqhuba iingxoxo ezinolwazi nabanikezeli babo bezempilo. Khumbula, olu lwazi alufanele lube endaweni yeengcebiso zonyango. Soloko unxibelelana nogqirha wakho we-oncologist okanye enye ingcali yezempilo efanelekileyo yesikhokelo esibekiweyo.

Ukuqonda ukuba unomhlaza ongenamncinci weselula (i-NSCLC)

Umhlaza womhlaza weseli ongenzi omncinci (I-NSCLC) Iiakhawunti malunga ne-85% yazo zonke ii-valer zomhlaza. Sisifo esibuhlungu, oko kuthetha ukuba kuveza ngokwahlukeneyo kubantu abohlukeneyo, kuchaphazela iindlela zokunyanga. Ukufunyanwa kwangoko kuphucula ubukhulu benqanaba lokusinda, ukuqaqambisa ukubaluleka kokuhlolwa rhoqo kunye nokuthatha ingqalelo ngokukhawuleza konyango ukuba iimpawu ziyavela. Uhlobo kunye nenqanaba le I-NSCLC ichaphazela kakhulu icebo lonyango.

Ukuma kwe-NSCLC

Ukubeka I-NSCLC, ngokuqhelekileyo isebenzisa inkqubo ye-TNM (i-tuma, i-node, i-metastasis), ibalulekile ekumiseleni iqhinga lonyango. Le nkqubo ivavanya ubungakanani be-tumar kunye nendawo, ukubandakanyeka kwe-lymph node, kunye nobukho be-metastases ekude. Uluhlu lwenqanaba ukusuka kwi-I (kwi-Play) kwi-IV (i-metastatitic), kwinqanaba ngalinye libonisa indlela eyahlukileyo yokuqina kunye nendlela yonyango. Ukuchazwa ngokuchanekileyo kufuna indibaniselwano yeemvavanyo zokucinga ezinjenge-CT Scans, isiKhangeli se-PET, kunye ne-biopsies.

Izinketho zoNyango lweNSCLC

Ukhetho lonyango lwe I-NSCLC Kuxhomekeka kakhulu kwinqanaba lomhlaza, impilo yesigulana iyonke, kunye nezinto ozithandayo. Ihlala ibandakanya indibaniselwano yonyango ukwandisa ukusebenza kunye nokuphucula iziphumo.

Utyando

Ukususwa kwe-sundor ye-tumor yindlela yokuqala yonyango lwenqanaba lokuqala I-NSCLC. Uhlobo lotyando luxhomekeke kwindawo ye-tumar kunye nobukhulu, olunokubandakanya i-lobectomy (isisu semiphunga), i-Pneonectomy (okanye i-segmertectomy (isuswa yecandelo elincinci lemiphu). Ubuchule obuncitshisiweyo bokungabinamsebenzi obufana notyando-utyando lwevidiyo

Chemotherapy

I-chemotherapy ibandakanya ukusebenzisa iziyobisi ukubulala iiseli zomhlaza. Ihlala isetyenziswa ngokudibeneyo nolunye unyango, njengokuhlinzwa okanye i-radiation pady, okanye njengonyango oluphambili kwinqanaba eliphezulu I-NSCLC. Iqhelekile isetyenziselwa amachiza e-chemotherapy I-NSCLC Faka iCisplatin, i-carboplaplatin, paclimaXal, kunye ne-docetaxel. Iziphumo ebezingalindelekanga zinokubaluleka kwaye ziyahluka ngokuxhomekeke kwiziyobisi ezithile kunye nedosi.

Unyango lwe-radiation

Unyango lwe-radiation lonyango lusebenzisa imitha yamandla amakhulu ukubulala iiseli zomhlaza. Ingasetyenziselwa ukuncitshiswa kwamathumba ngaphambi kotyando, ukutshabalalisa iiseli zomhlaza oshiyekileyo emva kotyando, okanye ukuphatha inqanaba eliphezulu I-NSCLC Ayinakususwa ngoxinzelelo. Unyango lwe-radiation ye-Biam lwangaphandle luhlobo oluqhelekileyo, luhambisa imitha kumatshini ngaphandle komzimba. Iziphumo ebezingafakwanga zidini, ukucaphuka kwesikhumba, kunye nesicaphucaphu.

Unyango olujolise kunyango

Ukugxila konyango ekugxilwe kuzo kwiimolekyuli ezithile ezichaphazelekayo kuhlumo lomhlaza kunye nokusinda. Ziluncedo kakhulu I-NSCLC Izigulana ezinolwazi oluthile lwendalo, ezinjenge-enFR, i-alk, iRos1, kunye nokuguqulwa kwe-BRAF. Ezi ntlalo zibonakalise impumelelo ebalaseleyo ekwenzeni amatyeli aphelise kwizigulana eziguquguqukayo. Imizekelo yonyango olujolisiweyo ibandakanya i-ERLOTINIBIB, Gefitinib, Craininib, kunye ne-AfAtinib.

I-gonotherapy

Ugonyo uhenyuza amajoni omzimba ukuze alwe iiseli zomhlaza. Isebenza ngokukodwa ekunyangeni I-NSCLC ngentetho ephezulu yePD-L1. Iziyobisi zokunyanga, ezinje ngePembrolimab, iNivolomab, kunye ne-Phitzlimbizob, iBetezzolizizmab, iBhloko yokuThengisa uMzimba, ivumela amajoni omzimba ukuze ahlasele iiseli zohlaza. Iziphumo ebezingahluka kodwa zibandakanya ukukhathazeka, imingxunya yesikhumba, kunye neziganeko ezimbi ezinxulumene nomzimba.

Ukukhetha isicwangciso sonyango esifanelekileyo

Ukukhetha Unyango lwe-NSCLC yinkqubo eyenzelwe wena kakhulu. Indlela efanelekileyo ixhomekeke kwimiba eyahlukeneyo, kubandakanya uhlobo oluthile kunye nenqanaba lomhlaza, impilo yesigulana, kunye nezinto azithandayo. Ukusebenzisana ngokusondeleyo phakathi kwesigulana kunye neqela labo lezempilo kubalulekile ukumisela eyona nto ilungileyo yesenzo. Iingxoxo ezibanzi kunye neengcali ze-oncologists kunye nezinye iingcali, kubandakanya oogqirha, ii-radiation zoochwephesha, kunye noochwephesha bonyango, zibalulekile ekuphuhliseni isicwangciso sonyango. Oku kufanele ukuba kube nakukhwela kungekuphela nje kunyango ngokwalo kodwa kunye nesicwangciso sokulawula nayiphi na imiphumo emibi.

Uhlobo lonyango	Ukusebenza	Imiphumela
Utyando	Iphezulu kwinqanaba lokuqala	Intlungu, usulelo, ubunzima bokuphefumla
Chemotherapy	Iyahluka ngokuxhomekeke kwinqanaba kunye nechiza	Isicaphucaphu, ukugabha, ukulahleka kweenwele, ukudinwa
Unyango lwe-radiation	Isebenza ngesifo esisebenzayo	Ukudinwa, ukucaphuka kwesikhumba, isicaphucaphu
Unyango olujolise kunyango	Isebenza kakhulu kuguquko oluthile	Ulusu lolusu, urhudo, ukudinwa
I-gonotherapy	Isebenza kwiindidi ezithile kunye namanqanaba	Ukudinwa, imingxunya yolusu, iziganeko ezingenamzimba ezinxulumene ne

Ngolwazi oluthe kratya ngonyango lomhlaza kunye nenkxaso, nceda undwendwele i IZiko loPhando lweShandong Baeo iwebhusayithi. Banikezela ngeendlela zokhetho eziphezulu zonyango kunye nenkxaso ebanzi yomntu obe ngumhlaza.

Iphepha elichazayo: Olu lwazi lucetywa ngeenjongo zemfundo kuphela kwaye akufuneki luthathelwe ingqalelo kwingcebiso yezamayeza. Soloko unxibelelana nengcali yokhathalelo lwempilo olufanelekileyo ukuze ufumane i-disnosis kunye nonyango lwemeko yonyango.

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