Unyango lwe-carcinoma ye-carcinoma: Imbono ye-pathology

Esi sikhokelo sibanzi siphonononga i-patology ye-recinoma (i-RCC), ipholile kwiindlela zayo ezahlukeneyo, iindlela zokuxilongwa, kunye neempembelelo zonyango. Sihlolisisa ii-microscopic, ukutshintsha kwemvelo, kunye nezinto eziqinisekileyo ezinxulumene ne-RCC, ukubonelela ngokuqonda okuneenkcukacha zabasebenzi bezempilo kunye nabaphandi.

Ukuqonda i-reacinal carcinoma

Ukuchaza i-RCC kunye nezitshixo zayo

I-renalin sel carcinoma, olona hlobo luqhelekileyo lomhlaza wezintso, ivela kwi-tubue ye-tubules yezintso. Zikho izityholo ezininzi, nganye ineempawu ezahlukileyo ze-pathothologics kunye nokuziphatha kweklinikhi. Oku kubandakanya i-RCC ecacileyo iRCC (i-CCHCc), i-papillary rcc (i-PRCEL), i-chromophobe i-Rcc (Chrcc), kunye nabanye. I-STAPT ezichanekileyo zibalulekile ekukhokeleni Unyango lwe-recinoma palkoma pathology kunye nokuxela kwangaphambili isifo. Uvavanyo oluchanekileyo luxhomekeke kuvavanyo lwe-microscopic kunye nogonyo lwe-gonohistochemical, ngokufuthi ifuna ubungcali kwiTenutolor yePagenology.

Iimpawu zeMicroscopic kunye neendlela zokuxilongwa

Ukuxilongwa kwe-RCC ngokuyintloko kusekwe kuvavanyo lwe-hisctopakhinological yeesampulu zezicubu ezifunyenwe kwi-biopsy okanye ikhutshiwe. Iimpawu ezithile ze-microscopic, ezinjengeSorphology, iimpawu zenyukliya, kunye neepateni zokukhula, nceda umahlise phakathi kwe-RCC. Umzekelo, i-CCHC iphawuleka nge-cytoplasm ecacileyo, ngelixa i-PRCC ibonakalisa uyilo lwe-papillary. I-uRununohistochemistry idlala indima ebalulekileyo ekuqinisekiseni i-disalonosis kwaye ichonge izinto ezithile eziphantsi, zinceda ukuphucula Unyango lwe-recinoma palkoma pathology Izicwangciso.

Utshintsho lwemfuzo kunye nemolekyuli yemolekyuli

Indima yeGenetics kwi-RCC yokuphuhlisa

Izinto eziphilayo zemvelo zidlala indima ebaluleke kakhulu kuphuhliso kunye nokuqhubela phambili kwe-RCC. Olona tshintsho luhlala rhoqo lubandakanya i-von hippel-lindau (VHL) i-tumoor i-tumor i-tumoor i-turustressor enesidima, ngakumbi kwi-CCRCc. Ezinye iintlobo zemfuza, njenge-PBRM1, i-bap1, kunye ne-SED2, nazo ziguqulelwa rhoqo kwiindawo ezahlukeneyo ze-RCC. Ukuqonda ezi tshintsho lwendalo kubalulekile ekuphuhliseni unyango kunye nokuphucula iziphumo zoguli. Iindlela eziphambili zeMolecular, ezifana nendlela elandelayo yokulandelelana, ziya kuqhubeka zinokuchonga ezi tshintsho, zikwazisa i Unyango lwe-recinoma palkoma pathology indlela.

Iimpembelelo kunyango olujolisiweyo

Ukuchongwa kovavanyo oluthile lwendalo kwi-RCC kukhokelele kuphuhliso lonyango olujolisiweyo. Umzekelo, i-inhibitors yento yokukhula ye-vascular endothelial endothelial (Vegf) kunye nethagethi yaseMammalian ye-radamycin (MTO) isetyenziswa rhoqo kwi-RCC ephezulu, ngakumbi abo bane-VHL. Ezi arhente zokujolisa zihlala zibonisa isibonelelo esibalulekileyo seklinikhi kwaye siphucule irhafu yokusinda. Uphando oluqhubekayo lwe-molecular of Rcc lwe-RCC luyaqhubeka nokumisa indlela ekugxilwe kuzo ngakumbi kunye neendlela zonyango ezizezakho.

Izinto eziqinisekileyo kunye neendlela zonyango

Ukuxela kwangaphambili i-Pregnosis kunye nokukhethwa konyango

Izinto ezininzi zinefuthe kwi-RCC-progenosis ye-RCC, kubandakanya inqanaba le-tumoor, ibakala, kunye netyhefu. Ubukho besifo se-metastatitic sinefuthe elikhulu kakhulu. Iimpawu ze-pathological, ezinjengeBakala leNyukliya kunye ne-necrosis, ikwanegalelo kukohliswa kobuqili. Olu vavanyo lwezinto ezicacileyo zentatheni lubalulekile ekukhokeleni izigqibo zonyango kunye nokulungelelanisa iindlela zonyango kwizigulana nganye nganye. Ukukhetha Unyango lwe-recinoma palkoma pathology Kuxhomekeka kakhulu kolu vavanyo.

Izinketho zonyango kunye ne-pathoical yazo

Izicwangciso zonyango ze-RCC ziyahluka ngokuxhomekeke kwinqanaba kunye nenqanaba lesi sifo. Ukuchithwa konyango lolona nyango luphambili kwi-RCC yendawo. I-Addst okanye i-mestastatic RCC, unyango lwenkqubo enjengee-Agents ekujoliswe kuzo okanye iMunotherapy iqashiwe. Ukukhetha unyango kuhlala kukhokelwa yi-pathological peatype, utshintsho lovelwano, kunye nempilo yempilo yesigulana. Uphando oluqhubekayo luphonononga iindlela zokuphambuka, ukuqokelela ukuqonda kwethu ukuqonda kweemoyeni zeemolekyuli ze-RCC.

Iindlela eziphambili ze-Rcc Pathology

IArnohistochemistry kunye nezicelo zayo

I-Ignohistochemistry (IHC) sisixhobo esibonakalayo kwi-Rcc Pathology. Abamakishi abathile, njenge-VHL, AMACR, kunye nePax8, isetyenziselwa ukuchonga iiphantsi kwe-RCC kwaye zahlula kwezinye ii-tumul amathumba. IHC ikwazi ukunceda ekuvavanyweni iBanga le-Tumor Gumation kunye nokuxela kwangaphambili isifo. Ngapha koko, i-IHC idlala indima ebalulekileyo ekuboneni iithagethi zonyango ezinokubakho, ezifundisa ngokwakho Unyango lwe-recinoma palkoma pathology Izigqibo.

Iindlela zemolekyuli ze-mothrear

Iindlela eziphambili zemolecular, ezinjengokulandelelana kwesizukulwana (i-NG) kunye ne-fluorescence kwi-HARCIBID (intlanzi), ziyasetyenziswa ngakumbi kwi-Rcc Pathology. I-NGS ivumela iprofayili ebanzi ye-gemic, echonga uluhlu olubanzi lwezinto eziphilayo ezinokuphembelela ukhetho lonyango kunye nokwenza impendulo kunyango. Intlanzi inokufumanisa ukuba i-chromosomal ethile engaqhelekanga, ibonelela ngokuqonda eyongezelelweyo kwibhayoloji ye-turum kunye neprograsi.

Olu lwazi lubonelelwe apha kwiinjongo zemfundo kuphela kwaye alunangqondo. Ukuchongwa kwesifo kunye nonyango lwe-carcinoma, nceda uqhagamshelane nengcali yezempilo efanelekileyo.

Ukufumana ulwazi oluthe kratya kunye nenkxaso, cinga ukutyelela i IZiko loPhando lweShandong Baeo iwebhusayithi. Banikezela ngezixhobo ezixabisekileyo kunye nobungcali boKhathalelo loMhlaza.