Unyango ekujoliswe kuwo iziyobisi

Eli nqaku libonelela ngamagqabantshintshi ngokubanzi Unyango ekujoliswe kuwo iziyobisi, ehlola iindlela zayo, izibonelelo, imiceli mngeni, kunye nezikhokelo ezizayo. Sivele kwiindlela ezahlukeneyo, kubandakanya i-nanotechnology, i-antidy-vecugites yeziyobisi, unyango lwemfuza, ivavanya ukusetyenziswa kwazo zeklinikhi kunye nophando oluqhubekayo. Funda malunga nezibonelelo zonyango ekujoliswe kulo xa kuthelekiswa ne-chemotherapy yemveli kunye neenzame eziqhubekayo zokuphucula ukusebenza kakuhle kunye nokunciphisa iziphumo ebezingalindelekanga.

Iindlela zokuhanjiswa kweziyobisi

Ukuhanjiswa kweziyobisi esekwe kwiziyobisi

I-nanotechnology idlala indima ebalulekileyo kwi Unyango ekujoliswe kuwo iziyobisi. Nanoparticles, due to their small size and ability to penetrate tissues, can deliver chemotherapeutic agents directly to tumor cells, minimizing exposure to healthy tissues. Iindidi ezahlukeneyo ze-Nanopartical, kuquka ne-Ipososomes, iPolymeric Nanoparticles, kunye ne-Nanopartics, kwaye zifundwe ngamandla abo ekwandiseni ukusebenza kweziyobisi kunye nokunciphisa ubuchule. Umzekelo, i-liposomal doxormicicin (i-Doxil) ivunyiswe ngekliniki kwiNkqubo yokuZiswa kweZiyobisi enciphisa i-Cardiotoocioty xa kuthelekiswa neDoxorubin eqhelekileyo. Uphando luyaqhubeka nokuphucula uyilo lwe-nanopriccarcle ye-NanoPrical yoGcino oluphuculweyo kunye nokukhupha i-kinetics kukhuphekile. IZiko loPhando lwe-Shandong Baena lithatha inxaxheba ngenkuthalo ekuphoseni inkqubela phambili yamva nje kule ndawo.

I-Antictur-Iyobisi leziyobisi (ADCs)

Ii-APCs zimele esinye isicwangciso esibalulekileyo ngaphakathi Unyango ekujoliswe kuwo iziyobisi. Ezi ntlalontle zonyango ziqukethe iziyobisi zeCytotoety ezidityaniswe ne-monoclonnika umntu ojolise ngqo kwiiseli zohlaza. Le ndlela iqinisekisa ukuba ichiza lithunyelwa ngokukhethekileyo kwiiseli zomhlaza, ukunciphisa iziphumo ekujoliswe kuzo kunye nokuphucula isalathiso sonyango. Imizekelo yee-ADCs ezivunyiweyo zibandakanya i-trastuzumab Edolosine (Kadcyla) ye-herner yakhe ye-heady kunye ne-brentckimab Vedatin (Adcetris) ye-Hodgkin ye-Hodgkin. Ukuqhubeka kophando kufezekisile ekuphuculeni i-anticture ejolise ngqo kunye nokuphuhlisa i-Noves cytotonity cytos.

Iindlela zokuhamba ngemfuza

Unyango lweGene lubonelela nge-avenue ethembisayo Unyango ekujoliswe kuwo iziyobisi. Le ndlela ibandakanya ukutshintsha imfuza ngaphakathi kwiiseli zomhlaza ukuba ithintele ukukhula kwethum okanye ukuphucula amandla amajoni omzimba ukulwa nomhlaza. I-proural prouder iqhele ukusetyenziswa ukuhambisa iintlobo zendlela yokujonga iiseli ekujoliswe kuzo. Olunye lophando uphonononge ubuchule bokuhlisha ehlekisayo njengeCrispR-Cas9 ukuze kulungiswe imfuyo yemfuza kunye nokuphucula ukusebenza.

Izibonelelo kunye nemiceli mngeni yokuhanjiswa kweziyobisi

Iinkqubo ekujoliswe kuzo iziyobisi zibonelela ngeenzuzo ezininzi ngakumbi i-chemotherapy, kubandakanya ukusebenza okuphuculweyo, kuncitshiswe ubunxila, kunye nokwandisa ububele. Nangona kunjalo, imiceli mngeni ihleli, kubandakanya ukuphuculwa kokunganyangeki ngamachiza, imfuneko yokuphuculwa kokujolise kuko, kunye neendleko eziphezulu zezi ntlalontle.

Itheyibhile 1: Ukuthelekisa kweendlela ekujoliswe kuzo iziyobisi

Izikhombisi zexesha elizayo kwindawo ekujoliswe kuyo iziyobisi

Igxile kuphando oluqhubekayo ngokujongana nokusikelwa umda kweenkqubo ezijolise kuyo iziyobisi kunye neendlela eziphuhlisayo zemovel. Oku kubandakanya ukuphuculwa kokujolisa kwiziyobisi, ukuphucula i-kinetics ukukhulula iziyobisi, kunye nokwahlula ukunganyangeki kwamachiza. Ukudityaniswa kwezicwangciso ezijolise kuzo, ukuvela kwezamayeza ezenzelwe, kunye nophuhliso lweenkqubo zokuhambisa iziyobisi kulindeleke ukuba ziphucule ukusebenza kunye nokhuseleko lwe Unyango ekujoliswe kuwo iziyobisi. Uqhubeke nophando kumaziko anje IZiko loPhando lweShandong Baeo ibalulekile ekuphuculeni le ntsimi.

Iphepha elichazayo: Olu lwazi luyinjongo lezemfundo kuphela kwaye akufuneki kuthathelwe ingqalelo icebiso lonyango. Soloko unxibelelana nengcali yezempilo ngayo nayiphi na inkxalabo yezempilo okanye ngaphambi kokwenza naziphi na izigqibo ezinxulumene nempilo yakho okanye unyango.

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