Unyango olujolise kwiziyobisi iziyobisi kwizibhedlele zomhlaza

Isikhokelo esibanzi sikhangela ukuqhubela phambili kunye nokusetyenziswa kwe Unyango ekujoliswe kuwo iziyobisi Ngaphakathi kwimeko yezibhedlele zomhlaza. Sinemikhono eyahlukeneyo, izibonelelo, imiceli mngeni, kunye nezikhokelo ezizayo zalo ntsimi ibalulekileyo, zibonelela ngokuqonda ezifanelekileyo kwiingcali zempilo kunye nabaphandi ngokufanayo. Ulwazi olubonisiweyo lusekwe kuncwadi lwesayensi lwangoku kunye neendlela zeshishini.

Ukuqonda ukuhanjiswa kweziyobisi

Yintoni ekujoliswe kuyo iziyobisi?

Unyango ekujoliswe kuwo iziyobisi Iinkqubo zenzelwe ukuba zinikezele ngokuthe ngqo iiarhente zonyango kwiiseli zomhlaza ngelixa kuncitshiswa umonakalo kwizicubu ezisempilweni. Le ndlela ijolise ekwenzeni ukusebenza kakuhle, ukunciphisa iziphumo ebezingalindelekanga, kunye nokuphucula iziphumo zesimo sengqondo xa kuthelekiswa neendlela zemveli zeChemotherapy. Kukho iindlela ezininzi zokufezekisa olu niso lujolise kulo, kubandakanya ukunxibelelana ne-antids-veshucas, i-nanoparticles, kunye ne-POSOMS.

Indlela yesenzo

Ezi nkqubo zihlala zisebenzisa i-ligands ejolise kwi-ligand, ezinjengee-antibodies okanye i-peptides, ebophelelanayo kwi-recertors oqinisekileyo kwiiseli zomhlaza. Nje ukuba kuboshwe, ichiza likhutshiwe, elikhokelela kunyango lwasekhaya kwaye inciphise ityhefu ye-cacioc. Ukukhetha indlela yokuhambisa kuxhomekeke kwizinto ezinje ngohlobo lomhlaza, iipropathi zeziyobisi, kunye nefuthe lonyango olufunwayo. Ukusebenza kakuhle kwe Unyango olujolise kwiziyobisi iziyobisi kwizibhedlele zomhlaza iphuculwe kakhulu kuphando oluqhubekayo.

Iindlela zokuhanjiswa kweziyobisi ekujoliswe kuzo

I-Antictur-Iyobisi leziyobisi (ADCs)

Ii-ADCs zidibanisa ichiza le-cytotoxic kunye ne-monoclonnika umntu ojolise kuMhlaza othile Antign. Le ndlela iqinisekisa ukuba ichiza linikezelwa kwiiseli zomhlaza, ukunciphisa umda wenkqubo kunye nokunciphisa iziphumo ezibi. Ii-ADC ezininzi zivunyiwe ukusetyenziswa kwengqondo kwaye zihlala zisetyenziswa kwiiprothokholi zonyango. Imizekelo iquka i-trastuzumab emthini (Kadcyla) kunye ne-Brentimab Ve Dotin (Adcetris).

Ukuhanjiswa kwe-nanoparcal

I-Nanoparclorles, ezinjenge-zeposomes, i-erasoric naprelicles, kunye ne-Nanopartics, zinokunika iiarhente zonyango kwaye ziphucule ukuhanjiswa kwabo kumathumba. La masuntswana anokuhlawulelwa ukujolisa kwiiseli ezithile kunye nezicubu, ukuphucula ukuqokelela iziyobisi ngaphakathi kwe-tumor micronvicrove. IZiko loPhando lweShandong Baeo https: //www.baofitaspital.com/ uphambili kolu phando.

I-Liposomal yokuhanjiswa kweziyobisi

I-Liposomes yi-vesicle ye-vesicle eqokelelwe zii-phospholipi ze-phospholipid ze-phospholipid ezinokwazisa iiarhente ezahlukeneyo zonyango. Banika ukhuseleko ekuthathweni kwento kwaye banokuphucula ixesha lokujikeleza kweziyobisi. Ngapha koko, i-iposomes inokuguqulwa ukuba ijolise kwiiseli ezithile okanye izicubu, ukuphucula ukuhanjiswa kweziyobisi kwindawo yethumba. I-DoCETAXEL, ichiza elisetyenziswa kakhulu i-chemotheratherapy, lihlala lenziwa kwifom ye-POPOSOMAL ukuphucula ukusebenza kwalo kunye nokunciphisa iziphumo ebezingalindelekanga.

Izibonelelo kunye nemiceli mngeni yokuhanjiswa kweziyobisi ekujoliswe kuwo

Izikhombisi zexesha elizayo kwindawo ekujoliswe kuyo iziyobisi

Uphando oluqhubekayo lujolise ekuphuhliseni ngakumbi Unyango ekujoliswe kuwo iziyobisi Iinkqubo ezinokuphuculwa okuphuculweyo, zinciphise ubugwenxa, kunye nokuphuculwa kokusebenza kakuhle. Oku kubandakanya ukuphonononga i-novel kugxininisa i-ligand, isebenzisa iindlela eziphambili zokujonga ukubek 'esweni ukuhanjiswa kweziyobisi, kunye nokuphuhlisa iindlela ezenziwe ngobuchule ngokusekwe kwiimpawu zesigulana ngamnye. Ukudityaniswa kwe-nanotechnology kunye nemmunotherapy inika isithembiso esibalulekileyo sokuqhubeka kwenkqubela phambili kwicandelo.

Uphuhliso kunye nokuphunyezwa kokusebenza Unyango olujolise kwiziyobisi iziyobisi kwizibhedlele zomhlaza Ifuna intsebenziswano phakathi kwabaphandi, abagqirha, kunye neenkampani zamayeza. Ukuqhubeka kotyalo mali kuphando kunye nophuhliso kubalulekile ekuguquleleni oku kuqhubela phambili kukhathalelo oluphuculweyo lwezigulana kunye neziphumo.

¹ Idatha kunye nolwazi olufunyenwe kwiijenali ezahlukeneyo zesayensi kunye neewebhusayithi zenkampani yamayeza. Iireferensi ezithile ezikhoyo kwisicelo.