Ukwelashwa komdlavuza we-BRCA Procostate

Ukuba khona kwe Genca gene ukuguqulwa kwemfuno, ngokuvamile kuhlotshaniswa nomdlavuza webele nomdlavuza we-ovarian, kungadlala nendima ebalulekile ekwakhiweni nasekwelashweni kwe umdlavuza we-Prostate. Ukuqonda okushiwo kwalokhu kuguqulwa kubalulekile kumasu okuthola ukwelashwa okwenziwe ngezifiso kanye nemiphumela yeziguli ethuthukisiwe. Lo mbhalo uhlola ukuxhumana phakathi Uhlobo lwe-BRCA na- umdlavuza we-Prostate, Ukuphuza ekuxilongeni, izinketho zokwelashwa, kanye nokucwaninga okuqhubekayo.qondisisa izinhlobo zofuzo ze-brca kanye ne-rolewhat yabo yi-brca1 kanye ne-brca2 genees?I-BRCA1 na- I-BRCA2 Ingabe izinhlobo zabantu zikhiqiza amaprotheni azibhekele ukulungisa i-DNA eyonakele. Lawa maprotheni adlala indima ebalulekile ekugcineni ukuqina kwemininingwane yethu yofuzo nokuvimbela ukukhula kwamaseli okungalawulwa. Lapho lezi zinhlobo zofuzo ziguqulwa, ngeke zisakwazi ukulungisa ngempumelelo ukulimala kwe-DNA, okwandisa ubungozi bokuthola umdlavuza othile.Ithonya le-brca eguqukayo emdlalweni I-BRCA1 na- I-BRCA2 zivame ukuhlotshaniswa nengozi eyandayo yomdlavuza webele nomdlavuza we-ovari kwabesifazane. Kodwa-ke, lezi zinguquko ziphakamisa ubungozi bamanye umdlavuza, kufaka phakathi umdlavuza we-Prostate, umdlavuza we-pancreatic, kanye ne-melanoma. Amadoda ane Genca gene Ukuguqulwa kwe-meation kunethuba eliphakeme lokukhulisa ngolaka ngokwengeziwe umdlavuza we-Prostate Emhlanganweni omncane we-Age.bra. I-BRCA1 noma I-BRCA2 ukuguqulwa kwezezimali eziphakeme kakhulu zokuthuthuka umdlavuza we-Prostate qhathanisa nabesilisa ngaphandle kwalokhu kuguqulwa. Ngaphezu kwalokho, umdlavuza we-Prostate emadodeni ane I-BRCA Ukuguqulwa kwezakhi zofuzo kuvame ukuba nolaka ngokwengeziwe, kuvame ukwethula esiteji esizayo nangamaphuzu aphezulu we-glaason. I-National Cancer Institute inikeza eminye imininingwane ku- I-BRCA Uhlobo lwengozi kanye nengozi yomdlavuza. I-BRCA1 na- I-BRCA2 ukuguqulwa kwezakhi zofuzo kunconyelwa amadoda anomlando womndeni we umdlavuza we-Prostate, ikakhulukazi uma umdlavuza watholakala esemncane noma uma kunomlando webele, i-ovarian, noma umdlavuza we-pancreatic emndenini. Ukutholwa kusenesikhathi ngokuhlola, okufana nokuhlolwa kwe-PSA (i-Prostate-Stroten Antigen) nezivivinyo ze-Digital Ructal, kubaluleke kakhulu kumadoda asengozini ephezulu. Ukuhlolwa kwezakhi zofuzo kuyatholakala nasezikhungweni ezifana I-Shandong Baafa Cancer Research Institute, lapho kuhlinzekwa khona ukuhlolwa kobungozi emdlavuza okwenziwe ngezifiso. umdlavuza we-Prostate emadodeni ane I-BRCA ukuguquguquka. I-Parp inhibitors isebenza ngokuvimba i-Enzyme ye-PARP, ebandakanyeka ekulungisweni kwe-DNA. Amaseli womdlavuza nge I-BRCA Ukuguqulwa kwezakhi zofuzo kusengozini yokuvinjwa kwe-PARP ngoba vele inendlela yokulungiswa kwe-DNA. Amanye ama-bherp ajwayelekile oku-inhibitors afaka i-Olaparib (Lynparza) kanye ne-rucaparib (i-rubraca). I-parp inhibitors isebenza kanjani I-BRCA Uhlobo lwezakhi zofuzo, amaseli womdlavuza eba neminye imigwaqo yokulungisa ama-DNA, kufaka phakathi indlela ye-PARP. Ngokuvimba i-Enzyme ye-PARP, ama-Parp inhibitors avimbela amaseli womdlavuza ekulungisweni kokulimala kwe-DNA, okuholela ekufeni kweseli. Le ndlela ebhekisiwe isebenza ngempumelelo ngaphakathi umdlavuza we-Prostate amaseli nge I-BRCA izinguquko, njengoba zingakwazi ukulungisa kahle ukulimala kwe-DNA ngokusebenzisa ezinye izindlela.clicical Team kanye nezilingo ze-Effessicalsinical zikhombise ukusebenza kweParp inhibitors ekwelapheni okuthuthukile umdlavuza we-Prostate emadodeni ane I-BRCA ukuguquguquka. Isibonelo, isivivinyo esikhulu sabonisa ukuthi u-Olaparib wathuthukisa kakhulu ukusinda okukusonke nokusinda okuqhubekayo okuqhubekayo kwabesilisa ngamadoda amelana ne-metastatic castration umdlavuza we-Prostate (MCRPC) kanye I-BRCA1 noma I-BRCA2 ukuguquguquka. Imiphumela evela ekulingweni okujulile ingatholwa ku- I-New England Journal of Medicine. umdlavuza we-Prostate ukwelashwa kungasetshenziswa futhi kwabesilisa abanayo I-BRCA ukuguquguquka. Lokhu kufaka phakathi: Ukuhlinzwa: I-radical prostatectomy (ukususwa kwe-prostate gland) kungaba inketho yendawo umdlavuza we-Prostate. Ukwelashwa kwemisebe: Ukwelashwa kwemisebe yangaphandle yangaphandle noma i-brachytherapy (imisebe yangaphakathi) kungasetshenziselwa ukuqondisa nokubhubhisa amaseli womdlavuza. Therapy Hormone: I-Androgen Dishivation Therapy (ADT) Ihlose ukwehlisa amazinga e-testosterone, okunganciphisa ukukhula kwe umdlavuza we-Prostate amaseli. I-Chemotherapy: Izidakamizwa ze-chemotherapy zingasetshenziswa ukwelapha okuthuthukile umdlavuza we-Prostate okusatshalaliswe kwezinye izingxenye zomzimba.Ikusasa locwaningo oluhlobene nomdlavuza we-prostate oluhlobene ne-brca kanye nokulingwa komtholampilo kuqhubeka nokuqonda iqhaza I-BRCA ukuguqulwa ku umdlavuza we-Prostate kanye nokwakha amasu amasha okuthola ukwelashwa. Ukuvivinywa kwemitholampilo kuhlola ukusetshenziswa kwama-purp inhibitors ngokuhlanganiswa nezinye izindlela zokwelapha, kanye nokuphenya imigomo yezidakamizwa yezidakamizwa kanye nezindlela zokwelashwa ezenziwe ngezifiso.Imithi ye-Oncology yokunemba ye I-BRCA ukuguqulwa ku umdlavuza we-Prostate Iziguli ziqokomisa ukubaluleka komuthi owenziwe umuntu kanye nokunemba kwe-oncology. Ngokuqonda izici zofuzo zomdlavuza womuntu, odokotela bangakwazi ukuvumelanisa amasu okulashwa ukukhulisa ukusebenza kahle futhi banciphise imiphumela emibi. Ukuhlolwa kofuzo kwe I-BRCA kanye nezinye izinhlobo ezihlobene nomdlavuza ziya ngokuya zivame kakhulu ngaphakathi umdlavuza we-Prostate Ukuphathwa.Table: Isifinyezo sezinketho zokwelashwa komdlavuza we-Proco-Fuated Protate Cancer Turcher Terfer Treatcher Treatment Inketho ye-BRCA ye-BRCA Parp ye-BRCA, izidakamizwa ezivimba izidakamizwa ze-PARP, ukuvimbela ukulungiswa kwe-DNA kumaseli womdlavuza. Isebenza kahle kakhulu, ikakhulukazi ezigabeni ezithuthukile. Ukususwa kokuhlinzwa kwe-Prostate Gland. Ifanele umdlavuza owenziwe yasendaweni; ukusebenza kahle akuxhunyaniswa ngqo nesimo se-brca. Ukusetshenziswa kwe-radiation therapy kwemisebe yamandla aphezulu ukubulala umdlavuza amaseli. Isimo esisebenzayo, kepha isimo se-BRCA singathonya impendulo. I-Hormone Therapy yehlisa amazinga e-testosterone ukunciphisa ukukhula komdlavuza. Ukwelashwa okujwayelekile, ukusebenza kahle kungaxhunyaniswa ngqo nesimo se-brca. Ukusetshenziswa kwe-chemotherapy kwezidakamizwa ukubulala amaseli omdlavuza. Kusetshenziswe ezigabeni ezithuthukile, isimo se-BRCA singathonya impendulo. Ukuqondisa Isixhumanisi Ukuxhumeka phakathi Uhlobo lwe-BRCA na- umdlavuza we-Prostate kubalulekile ukwenza ngcono ukuxilongwa, ukwelashwa nemiphumela yabantu abathintekile. Ukuhlolwa kwezakhi zofuzo, izindlela zokwelapha ezihlosiwe ezinjenge-Parp inhibitors, kanye nocwaningo oluqhubekayo luveza indlela yezindlela ezenzelwe wena nezimpumelelo zokuphatha umdlavuza we-Prostate emadodeni ane I-BRCA ukuguquguquka. Amadoda anomlando womndeni wa umdlavuza we-Prostate Noma okunye umdlavuza ohlobene kufanele abheke ukuhlolwa kofuzo futhi axoxe ngezindlela ezifanele zokuhlola nabahlinzeki babo bezempilo. Ochwepheshe abazinikezele ezikhungweni ezifana I-Shandong Baafa Cancer Research Institute, eyaziwa nge-Cancer Trancer Treatment, bafaka isandla ngenkuthalo entuthukweni kulo mkhakha.