Izinhlelo ezishibhile ezilawulwa izidakamizwa zokulethwa kwezidakamizwa

Lo mbhalo uhlola isimo sokungabizi futhi esisebenzayo Ukulethwa kwezidakamizwa okulawulwa okushibhile okushibhile izinhlelo. Sizohlola ubuchwepheshe obuhlukahlukene, izinzuzo zabo kanye nobunzima babo, futhi izici zinomthelela ekusebenzeni kahle kwezindleko. Funda ngezindlela ezahlukahlukene ukufezekisa ukukhishwa kwezidakamizwa okulawulwayo futhi uthole ukuthi yiziphi izinketho ezingcono kakhulu ezifanele ukwelashwa okuthile. Lo mhlahlandlela ophelele uzokusiza ekutholeni ubunzima bale ndawo ebalulekile ekuthuthukisweni kwemithi.

Ukuqonda ubuchwepheshe bokukhishwa obulawulwa

Ukulethwa kwezidakamizwa okulawulwa okushibhile okushibhile inikeza izinzuzo ezibalulekile ngaphezulu kokuphathwa kwezidakamizwa okuvamile. Ngokulawula isilinganiso lapho kukhululwa khona umuthi, lezi zinhlelo zingathuthukisa ukusebenza kahle kokwelapha, zinciphise imiphumela emibi, futhi zithuthukise ukulandelwa kweziguli. Lokhu kutholakala ngezinqubo ezahlukahlukene, ngayinye inemiphumela yayo yezindleko.

Izindlela zokukhishwa okulawulwayo

Izindlela eziningana zenza ukukhishwa kwezidakamizwa okulawulwayo. Lokhu kufaka phakathi:

• Ama-Matrix Systems: Umuthi uhlakazeka ngaphakathi kwe-matrix ye-polymeric elawula isilinganiso sayo sokukhishwa. Ukusebenza kwezindleko kwale ndlela kuncike kakhulu ekukhetheni kwe-polymer.
• Izinhlelo ze-Reservoir: Lesi sidakamizwa sifakwe ngaphakathi kwe-reservoir, futhi ukukhululwa kwaso kulawulwa ngulwelwesi olulawulwa kakhulu isilinganiso. Le ndlela inganikeza ukulawula okuqondile kepha ingahle ibiza kakhulu kunezinhlelo ze-matrix.
• Izinhlelo zokuguguleka: Uhlelo lokulethwa kwezidingo luyaphaza kancane, lukhipha umuthi ngesilinganiso esilawulwayo. Izinga lokuguguleka linqunywa yizakhiwo zezinto zohlelo.
• Izinhlelo ze-Osmotic: Lezi zinhlelo zisebenzisa ingcindezi ye-osmotic ukushayela ukukhishwa kwezidakamizwa. Imvamisa banikela ngamaphrofayili okukhipha angaguquki kepha bangaxaka ukukhiqiza.

Izici ezithinta izindleko zezinhlelo zokukhishwa ezilawulwayo

Izindleko ze Ukulethwa kwezidakamizwa okulawulwa okushibhile okushibhile Isistimu incike ezintweni ezahlukahlukene. Lokhu kufaka phakathi:

Izindleko ezibonakalayo

Ukukhethwa kwezinto zokwakha kuthonya kakhulu izindleko zizonke. I-Biodegradable Polymers, ngenkathi unikeza izinzuzo njengokuhlaselwa okuncishisiwe, kungabiza kakhulu kunezinkulumo ezingezona ezengeziwe. Ukukhethwa kwezinto ezifanele, ezisebenza ngezindleko kubalulekile ukuklama amasistimu wezomnotho.

Ukukhiqiza ubunzima

Izinqubo zokukhiqiza eziyinkimbinkimbi, ezinjengalezo ezidingekayo ze-microsloes noma ama-nanoparticles, zingakhulisa izindleko zokukhiqiza. Amasistimu alula afana namathebulethi alula anezigqoko zokukhishwa ezilawulwayo zinganikeza isisombululo esingesi esibizayo.

Isikali sokukhiqizwa

Izindleko ngeyunithi ngayinye zivame ukwehla ngezinga lokukhiqiza elikhuphukayo. Ukukhiqiza okulinganiselwe kungazuza kwezomnotho ezikalini, kungenzeka Ukulethwa kwezidakamizwa okulawulwa okushibhile okushibhile kufinyeleleka kakhudlwana.

Izibonelo zezinhlelo ezishibhile ezilawulwa ezilawulwa kwezidakamizwa

Izibonelo eziningi zibonisa uhla lwe-etholakalayo Ukulethwa kwezidakamizwa okulawulwa okushibhile okushibhile Technologies:

Amaphilisi wokukhishwa alawulwa ngomlomo

Imithi eminingi yezentengiselwano yomlomo etholakala ngomlomo isebenzisa ukwakheka okulawulwa okulawulwayo, ivame ukusebenzisa ama-polymers angabizi kakhulu namasu okukhiqiza ukufezekisa izindleko. Lokhu kusetshenziswa kabanzi ngezimo ezingamahlalakhona ezidinga amazinga wezidakamizwa angaguquki.

Iziqeshana ze-transdermal

Ngenkathi kuvame ukuxaka kakhulu kunezinhlelo zomlomo, iziqalo zeTransdermal zisebenza ngokuletha izidakamizwa ngezikhathi ezengeziwe. Ukusungula ubuchwepheshe bokunamathela futhi ulwelwesi-membrane kuyimizamo yokushayela izinketho ezingabizi.

Izitayela zesikhathi esizayo ekunikezelweni kwezidakamizwa okulawulwa kwezidakamizwa okushibhile

Ucwaningo luhlala lucindezela imingcele yokulethwa kwezidakamizwa okulawulwayo. Ukuthuthukiswa kwenoveli yesayensi yezinto ezivelayo

Ukuqhubeka nokucwaninga nokungakhethwa ngokwelashwa okukhethekile, ungafisa ukubheka izinsiza ezifana ne I-Shandong Baafa Cancer Research Institute.

Ukuzikhulula: Le ndatshana inikezela ngemininingwane ejwayelekile futhi akufanele ibhekwe njengezeluleko zezokwelapha. Xhumana nochwepheshe wezokunakekelwa kwempilo kunoma yikuphi ukukhathazeka ngempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo yakho noma yokwelashwa.