Ukwelashwa kwezidakamizwa okushibhile okushibhile

Ukwelashwa kwezidakamizwa okuqhubekayo okuqhubekayo: Isihloko esiphelele sesiqondiso sihlola intuthuko kanye nokucatshangelwa okuphathelene nokwelashwa kwezidakamizwa okushibhile kwezidakamizwa, kuhlolisise amasu ahlukahlukene, izinzuzo, izinselelo kanye nezinkomba zesikhathi esizayo. Sisebenzisa izibonelo ezithile, ukusebenza kwezindleko kuhlaziya, kanye nezinhlelo zokusebenza ezingaba khona, ukuhlinzeka ngokuqonda okucacile kwale ndawo ebalulekile ekuthuthukisweni kwemithi.

Ukwelashwa okushibhile okushibhile ukulethwa kwezidakamizwa: umhlahlandlela ophelele

Izinhlelo zokulethwa kwezidakamizwa ezigciniwe (ama-SRDDs) zinikeza enye indlela ephoqelekile yamafomu we-donsa yendabuko, enikeza izinzuzo eziningi zeziguli kanye nabahlinzeki bezokunakekelwa kwempilo. Kodwa-ke, izindleko zentuthuko nokukhiqiza kungaba isithiyo esikhulu. Lo mhlahlandlela uhlola amasu okufeza Ukwelashwa kwezidakamizwa okushibhile okushibhile, ukuhlola ubuchwepheshe obuhlukahlukene kanye namaphrofayili abo okusebenza kwezindleko. Sizocubungula izici ukuthonya izindleko, kubandakanya nokukhethwa kwezinto ezibonakalayo, izinqubo zokukhiqiza, kanye nokuqina. Ekugcineni, lokhu kuhlola kuhlose ukukhanyisa izindlela ezibhekise ekufinyeleleni kakhulu nasekushintshishelwe kwalezi zinto ezibalulekile zokwelapha.

Ukuqonda ukulethwa kwezidakamizwa okuqhubekayo

Izindlela zokulethwa kwezidakamizwa zendabuko zivame ukuholela ekuguquguqukeni kwezidakamizwa emzimbeni, okuholela emiphumeleni emibi engaba khona kanye nokusebenza kwezokwelapha okungaphansi. Ukwelashwa kwezidakamizwa okushibhile okushibhile Ihlose ukunqoba lokhu kulinganiselwa ngokukhulula umuthi ngesilinganiso esilawulwayo esikhathini eside. Lokhu kukhishwa okulawulwayo kunciphisa ukugxila okuphezulu, kuthuthukisa ukuhambisana kweziguli (ngenxa yokuthola imali evamile), futhi kuvame ukuthuthukisa imiphumela yokwelapha. Ubuchwepheshe obuningana bufeza lokhu kukhishwa okulawulwayo, ngamunye unemiphumela yezindleko ezahlukahlukene.

Ubuchwepheshe be-SRDDS ejwayelekile kanye nemiphumela yabo yezindleko

Ubuchwepheshe	Umshini	Izindleko	Izibonelo
Amasistimu we-matrix	Izidakamizwa ezihlakazekile ku-matrix ye-polymeric; ukukhishwa kwenzeka ngokuxhamazela noma ukuguguleka.	Izindleko ze-polymer, ukukhiqiza ubunzima.	Imishanguzo eminingi yomlomo eminingi yezentengiselwano.
Izinhlelo ze-Reservoir	Izidakamizwa eziqukethwe ngaphakathi kwe-reservoir, zikhishwe ngolwelwesi olulawulwa kakhulu isilinganiso.	Izindleko zezinto ezibonakalayo, ukukhiqiza ngokunemba.	Ama-Transdermal patches, amadivaysi afakiwe.
Amaphampu we-osmotic	Ingcindezi ye-Osmotic ishayela ukukhishwa kwezidakamizwa ngolwelwesi olungavunyelwe khona.	Ukuxaka kwedivayisi, izindleko ezibonakalayo.	Imithi yomlomo yemibandela ethile.

Ithebula 1: Ukuqhathaniswa kobuchwepheshe be-SRDDS nezindleko

Izici ezithinta izindleko ze Ukwelashwa kwezidakamizwa okushibhile okushibhile

Izindleko ze Ukwelashwa kwezidakamizwa okushibhile okushibhile kuthonywa yizici eziningi. Ukukhetha ngokwezinto ezibonakalayo kudlala indima ebalulekile; Ama-pooculo ahambisanayo ama-kinetics avumayo kepha izindleko eziphansi zibalulekile. Izinqubo zokukhiqiza, kufaka phakathi amandla okulinganisa, zithinta kakhulu izindleko eziphelele. Izindlela zokukhiqiza ezisebenza kahle neziqondisiwe zibalulekile ukuze kufinyelelwe ezomnotho ezikalini. Izindlela zokulawula kanye nokucatshangelwa kwempahla yengqondo nakho kufaka ne-Workscape yezwe lonke.

Amasu okunciphisa izindleko

Amasu amaningana angaqashwa ukunciphisa izindleko ze Ukwelashwa kwezidakamizwa okushibhile okushibhile. Lokhu kufaka phakathi ukusetshenziswa okushibhile, izinto ezitholakala kalula ngenkathi kugcinwa ukusebenza ngempumelelo. Ukusebenza kwenqubo kanye ne-automation kunganciphisa kakhulu izindleko zokukhiqiza. Ukuhlola obunye ubuchwepheshe bokwenziwa, njengokuphrinta kwe-3D, kungaholela ekukhiqizweni okusebenzayo futhi okungabizi kakhulu. Ukubambisana phakathi kwezikhungo zocwaningo kanye nezinkampani ezenza imithi kungakhuthaza ubuciko futhi kunciphise izindleko zokuthuthuka.

Izinkomba zesikhathi esizayo kuma-SRDD ezingabizi

Ikusasa le Ukwelashwa kwezidakamizwa okushibhile okushibhile amanga ekusungulweni okuqhubekayo nokucwaninga. Ukuthuthukiswa kwenoveli ehambisanayo ne-poocomorable polymers ngezimpawu eziphakeme zokukhishwa nezindleko eziphansi kubalulekile. Ukuthuthuka kwe-nanotechnology kanye nokulethwa kwezidakamizwa okuhlosiwe kungathuthukisa ukusebenza ngempumelelo futhi kungenzeka ukuthi kunciphise inani lezidakamizwa ezidingekayo, okuholela ekugcinweni kwezindleko. Ukucwaninga okwengeziwe kumasu okukhiqiza angenazindleko kanye nokwenziwa lula kwezindlela zokulawula kuzophinda kudlale indima ebalulekile ekukhuliseni ukufinyelela kuma-SRDD angabizi.

Ukuthola eminye imininingwane ngocwaningo lomdlavuza nokwelashwa, ungathola I-Shandong Baafa Cancer Research Institute Iwebhusayithi isize. Banikela ngokuqonda okubalulekile nezinsizakusebenza ezihlobene nentuthuko ku-Oncology.

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo yakho noma yokwelashwa.