Ukulethwa kwezidakamizwa okubhekiselwe okushibhile kwezibhedlela ezinomdlavuza

Lo mbhalo uhlola amasu angenazimali okulethwa kwezidakamizwa okubhekiswe ezibhedlela umdlavuza, uhlole ubuchwepheshe obusha, ukufeza izinqubo zokwelashwa, kanye nezinsizakusebenza zokunikeza izinkinga zesabelomali ngenkathi ziphatha izingqinamba zesabelomali. Sisebenzisa ngezindlela ezahlukahlukene, sihlaziya ukusebenza kwazo, ukusebenza kwezindleko, kanye nokufaneleka kwezinhlobo zomdlavuza ezihlukene kanye nezilungiselelo zesibhedlela.

Ukuqonda isidingo sokulethwa kwezidakamizwa okubhekiselwe okushibhile

Ukwelashwa komdlavuza kuyabiza. Ukuthuthukiswa kanye nokuqaliswa kwe Ukulethwa kwezidakamizwa okuhlosiwe okuhlosiwe Izindlela zibalulekile ngokwandisa ukufinyeleleka kwezindlela ezintsha zokwelapha. I-Chemotherapy yendabuko ivame ukuntuleka ngokucaciswa, okuthinta amaseli anempilo eceleni kwabanemali, okuholela emiphumeleni emibi ebalulekile kanye nezindleko zokwelashwa eziphakeme. Izinhlelo ezibhekiswe ezidakamizweni ezihlosiwe zihlose ukugwema lokhu ngokuletha abenzeli bezokwelapha ngqo kumasayithi esishayamthetho, ukunciphisa ukulimala kwezicubu ezinempilo. Lokhu kuphumela ekusebenzeni kahle kwempumelelo, kuncishiswe imiphumela emibi, futhi kungase kuncishiswe izindleko zokunakekelwa kwezempilo. Isidingo sezixazululo ezisebenzayo nezingabizi zibaluleke kakhulu kwizilungiselelo ezicindezelwe izinsiza.

Ubuchwepheshe obusha bokulethwa kwezidakamizwa okuhlosiwe okungabizi kakhulu

Ukulethwa kwezidakamizwa okususelwa ku-nanotechnology

I-Nanotechnology inikeza izindlela ezithembisayo ze Ukulethwa kwezidakamizwa okuhlosiwe okuhlosiwe. Ama-nanoparticles angenzelwe ukuvumela ama-ejenti wezokwelapha avela ekwakhiweni nasekuvumelwaneni ukulethwa okuhlosiwe kumaseli ahlukahlukene abonisa izindlela zokuhlobisa ezifanayo (ukuqondiswa okusebenzayo (usebenzisa ama-ligands ahlanganisa ama-receptors athile kumaseli womdlavuza). Ngenkathi izindleko zokuqala zocwaningo nezindleko zentuthuko ziphezulu, amandla okukhiqiza amakhulu kanye nokuncishiswa kwezikhathi zokwelashwa kungaholela emalini yezindleko zesikhathi eside. Izikhungo eziningana zokucwaninga, kufaka phakathi I-Shandong Baafa Cancer Research Institute, zihlola ngenkuthalo le ndawo.

Ukulethwa kwezidakamizwa kwe-Liposomal

Ama-liposomes, ama-visicles ayindilinga aqanjwa ngababili be-phospholipid, kungenye indlela ephumelelayo yokulethwa kwezidakamizwa okuhlosiwe. Bangakwazi ukuvumela izidakamizwa ezahlukahlukene zezimpikiswano, zivikele ekuwohlokeni nasekuthuthukiseni isikhathi sabo sokujikeleza. Ukwakhiwa kwe-liposomal kungenziwa kwenzelwe ukubhekisa amaseli athile we-tumorm, okuholela ekusebenzeni kahle kokwelapha okuthuthukisiwe kanye nemiphumela emibi encishisiwe. Ukusebenza kwezindleko zokulethwa kwezidakamizwa ze-liposomal kuncike ekwakhekeni okuthile kanye nesilinganiso sokukhiqiza. Kodwa-ke, intuthuko emasu akhiqizayo yenza ama-Liposomoral avume ayafinyeleleka.

Izimbotshana zezidakamizwa ze-antibody-Drug (ADCs)

I-ADCS ihlanganisa amakhono okuhlosiwe ama-antibodies e-monoclonal nemiphumela ye-cytotoxic yezidakamizwa ze-chemotherapeapeutic. I-antibody ibopha ngokuqondile kumaseli womdlavuza, ukuletha ukulayisha kwe-cytotoxic ngqo kwisiza se-tumor. Ngenkathi ama-adcs njengamanje ebiza kakhulu kunama-chemitapies amaningi ajwayelekile, ucwaningo oluqhubekayo lugxile ekuthuthukiseni ukukhiqizwa kwalo kanye nokusebenza ngempumelelo ukuze kubenze bafinyeleleke kalula.

Ukunxusa amaphrothokholi wezokwelapha kanye nokuphathwa kwezinsizakusebenza

Ngaphezu kwentuthuko yezobuchwepheshe, ukufeza izinqubomgomo zokwelashwa kanye nokuphathwa kwezinsiza kubalulekile ukuze uzuze Ukulethwa kwezidakamizwa okuhlosiwe okuhlosiwe. Lokhu kufaka phakathi:

Umuthi owenziwe umuntu: Ukuhambisana nezinhlelo zokwelashwa ezisuselwa ezifweni zeziguli ngazinye, kufaka uhlobo lwe-tumor kanye nephrofayili yofuzo, kungathuthukisa ukusebenza kwezokwelashwa futhi kunciphise izindleko ezingadingekile.
Ukutholwa kusenesikhathi nokuhlola: Ukutholwa kusenesikhathi kungaholela kumasu amancane okuthola imali ephakeme futhi angabizi kakhulu.
Ukuphathwa Kwezidakamizwa Okuthuthukisiwe: Ukuqalisa ukusebenzisa amandla okulawula okuqinile kanye nezinhlelo zokunciphisa imfucuza kunganciphisa kakhulu izindleko zezidakamizwa.
Ukusebenzisana nokwabelana ngolwazi: Ukwanda ngokubambisana kwabaphenyi, odokotela, kanye nabahlinzeki bezempilo kubalulekile ekwakheni nasekusebenziseni amasu angenazimali.

Ukuqhathanisa Ukuqhathanisa Kwezindleko

Indlela Yokulethwa Kwezidakamizwa	Izinzuzo	Okubi	Ukusebenza kwezindleko
Nanotechnology	Ukucaciswa okuphezulu, imiphumela emibi encishisiwe	Izindleko eziphezulu ze-R & D	Okungaba khona imali ende yesikhathi eside
Liposomes	Ukuqina kwezidakamizwa okuthuthukisiwe, ukuthuthukiswa okuthuthukile	Izinselelo Zokukhiqiza	Kuya ngokuya kubiza kakhulu
I-ADCS	Ukucaciswa okuphezulu, umphumela onamandla we-cytotoxic	Izindleko eziphezulu zokukhiqiza	Kuyabiza njengamanje, amandla okunciphisa izindleko ezizayo

QAPHELA: Lokhu kuhlaziywa kwezindleko zokusebenzisa imali kungukubuka konke okujwayelekile nezindleko ezithile zingahluka ngokuya ngezinto ezahlukahlukene kufaka phakathi uhlobo lwezidakamizwa, umthamo kanye nesibhedlela.

Ukugcina

Ukuphishekela Ukulethwa kwezidakamizwa okuhlosiwe okuhlosiwe Ezibhedlela zomdlavuza ziyindawo ebucayi yocwaningo nentuthuko. Ngokuhlanganisa ubuchwepheshe obusha nokwelashwa okwenziwe kahle kokwelashwa kanye nokuphathwa kwezinsizakusebenza, izinhlelo zokunakekelwa kwempilo zingathuthukisa imiphumela yeziguli ngenkathi zilawula izindleko. Ukutshala imali okuqhubekayo ocwaningweni nasemikhakheni yokubambisana kubalulekile ukuze kufezekiswe le nhloso kanye nokwandisa ukufinyelela ekwelashweni okusonga impilo.