Ukwelashwa komdlavuza wamaphaphu okuhlola

Ukwelashwa komdlavuza wamaphaphu okuhlola: Ukuqonda okuphelele kwesizinda se-landscape Ukwelashwa komdlavuza wamaphaphu okuhlola Izinketho zibalulekile ezigulini nasemindenini yazo. Le ndatshana ihlinzeka ngesibukezo sokwelashwa okusikayo, ukugqamisa izinzuzo zayo ezingaba khona, ukulinganiselwa, kanye nezinkomba zokucwaninga zamanje. Sizohlola izindlela ezahlukahlukene zokwelashwa, sigcizelela ukubaluleka kokunakekelwa komuntu ngamunye nokuhlola okuqhubekayo kwemitholampilo.

Izinhlobo Zokwelapha Umdlavuza Wezamaphaphu Wokuhlola

Ukwelashwa okuhlosiwe

Izindlela zokwelapha ezihlosiwe zigxile ekubukeni okuthize zofuzo ngaphakathi kwamaseli womdlavuza, kubenza baqonde ngokwengeziwe kunokwemvelo kwe-chemotherapy. Lezi zindlela zokwelapha zingafaka phakathi ama-tyrosine kinase inhibitors (TKIS) okuhlosiwe okuhlosiwe okuthile okufana nokuguqulwa okukhethekile okufana ne-egfr, alk, ros1, ne-braf. Ukusebenza kahle kwezindlela zokwelapha ezihlosiwe kuyahluka kakhulu ngokuya ngephrofayili ethile yofuzo. Isibonelo, umdlavuza wamaphaphu oguquliwe oguquliwe uvame ukuphendula kahle ku-EGFR TKIS njengeGefitiinib noma erlotinib. Kodwa-ke, ukumelana kungakhula ngokuhamba kwesikhathi, kudinga ushintsho kucebo lokwelashwa. Izilingo zemitholampilo zihlala zihlola izindlela ezintsha zokwelapha ezihlosiwe nezindlela zokuhlanganisa ukunqoba ukumelana. Khumbula njalo uxoxa ngezinketho zokwelashwa ne-Oncologist yakho, ngoba zingakuqondisa ohlelweni olufanele kakhulu ngokususelwa ezimweni zakho ezihlukile.

I-ImmunoSatherapy

I-ImmunoSatherapy ihlanganisa amandla amasosha omzimba uqobo ukuze alwe nomdlavuza. I-Imc Vipoint inhibitors (ICIS), njenge-pembrolikumab ne-nivolumab, amaprotheni avimba amaseli omzimba ekuhlaseleni amaseli omdlavuza. Lolu hlobo lwe Ukwelashwa komdlavuza wamaphaphu okuhlola Ukhombisile impumelelo emangalisayo kwezinye iziguli, okuholela ekuxoliseni isikhathi eside kwezinye izimo. Kodwa-ke, akuzona zonke iziguli ezisabe ama-immunotherapy, nemiphumela emibi ingabaluleka. Abaphenyi bahlola ngenkuthalo izindlela zokuthuthukisa ukusebenza kahle nokuphepha kwe-ImmunoSatherapy, okubandakanya ukuhlanganisa nezinye izindlela zokwelapha ezinjenge-chemotherapy noma ukwelashwa okuhlosiwe.

Amagciwane acolytic

Amagciwane e-ocolytic angamagciwane anezofuzo atheleleka ngokukhetha futhi acekele phansi amangqamuzana omdlavuza ngenkathi eshiya amaseli aphilile angalimalanga. Le ndlela isezigabeni zayo zokuqala zentuthuko yomdlavuza wamaphaphu, kepha ikhombisa imiphumela ethembisa ezifundweni zemvelo kanye nezilingo zokuqala zemitholampilo. Amandla alolu hlobo Ukwelashwa komdlavuza wamaphaphu okuhlola Amanga emandleni ayo okuqondisa ngokuqondile nokubulala amaseli womdlavuza futhi ngokunamandla okuvuselela impendulo yokuzivikela komzimba.

I-Car T-Cell Therapy

I-Chimeric Antigen Receptor (Car) T-cell Therapy ifaka ukuguqula amaseli we-T wesiguli ukuze aqaphele futhi ahlasele amaseli umdlavuza. Le ndlela eqondene nomuntu uqobo ikhombisile impumelelo emangalisayo emidlavuza ethile yegazi, kepha ukusetshenziswa kwayo emdlavuza wamaphaphu kusaphenywa. Izilingo zemitholampilo ziyaqhubeka zihlola ukuphepha kanye nokusebenza kahle kwezokwelapha ze-T-cell cell kumaphaphu ahlukahlukene omdlavuza wamaphaphu. Kudingeka ucwaningo oluningi ukuze kunqunywe indima yalo endaweni ebanzi yamaphaphu yomdlavuza womdlavuza.

Ukukhetha ukwelashwa okulungile kokuhlola

Ukukhetha kufanelekile Ukwelashwa komdlavuza wamaphaphu okuhlola Kudinga ukucubungula ngokucophelela kwezinto eziningana, kufaka phakathi impilo yesiguli, isigaba nohlobo lomdlavuza wamaphaphu, kanye nezinzuzo ezingaba khona kanye nezingozi zenketho yokwelashwa ngakunye. Ithimba labachwepheshe abaningi, kufaka phakathi ama-Oncologists, odokotela abahlinzayo, ama-radiologists, nabanye ochwepheshe bezokunakekelwa kwempilo, ngokuvamile basebenza ndawonye ukuthuthukisa uhlelo lokwelashwa oluqondene nomuntu ngamunye. Ukubamba iqhaza esivivinyweni somtholampilo kunganikezela ukufinyelela kwezindlela ezintsha zokuvuselela futhi kufake isandla ekuthuthukiseni ucwaningo lomdlavuza. Kubalulekile ukuba nezingxoxo ezivulekile nezithembekile nethimba lakho lezokunakekelwa kwempilo ukwenza izinqumo ezinolwazi. Ukuqonda ucwaningo lwakamuva nokuhlala unolwazi ngezinketho ezintsha zokwelashwa kubalulekile ukuze uzulazule lolu hambo olunzima. Ukuthola eminye imininingwane nokusekelwa, ungacabanga ngokubonisana nezinsizakusebenza ezinjengeNational Cancer Institute (NCI) noma i-American Lung Association.

Izilingo Zomtholampilo Nokucwaninga

Ukubamba iqhaza esivivinyweni somtholampilo kunikeza ukufinyelela kwakamuva Ukwelashwa komdlavuza wamaphaphu okuhlolas futhi unikela ngemininingwane ebalulekile ukuze uqhubekele phambili insimu. I-National Cancer Institute (NCI) igcina i-database ephelele yokulingwa kwemitholampilo, ukuhlinzeka ngemininingwane ngezinqubo zokufaneleka kanye nezikhungo ezibamba iqhaza. Izikhungo eziningi, kufaka phakathi i-Shandong Bandong Bandong Cancer Research Institute (https://www.baofahospital.com/), bahlanganyela ngenkuthalo ekucwaningweni komdlavuza wamaphaphu futhi banikeze iziguli amathuba okubamba iqhaza ekusikeni kokusika kwemitholampilo. Lezi zilingo ziphenya ukwelashwa okusha, zihlola ukuhlanganiswa okuthuthukile kwezindlela zokwelapha ezikhona, futhi ziphenya izindlela zokwenza ngcono impilo yalabo abathintwe yilesi sifo. Ngaphambi kokubhalisa enkantolo, kubalulekile ukuze uqonde kahle izinqubo, izinzuzo nezinzuzo ezingaba khona, kanye nokuzibophezela okuhilelekile.

Ithebula: Ukufingqwa kwezinto zokwelapha umdlavuza wamaphaphu

Uhlobo lokwelashwa	Umshini	Izinzuzo Ezingaba khona	Ukulinganiselwa
Ukwelashwa okuhlosiwe	Kuhlose ukuguqulwa okuthile kofuzo	Ukusebenza kahle okuphezulu ekuguqukeni okuthile, imiphumela emibi embalwa uma iqhathaniswe ne-chemotherapy	Ukuthuthukiswa kokumelana, akusebenzi kuzo zonke iziguli
I-ImmunoSatherapy	Kuqinisa amasosha omzimba ukulwa nomdlavuza	Ukuxolelwa isikhathi eside kwezinye iziguli	Ayisebenzi kuzo zonke iziguli, imiphumela emibi ebalulekile kungenzeka
Amagciwane acolytic	Ama-virus anezinhlobo zofuzo aqondise amaseli womdlavuza	Ukuvinjelwa okukhethiwe kwamaseli womdlavuza	Isigaba sokuqala sokuthuthuka, imiphumela yesikhathi eside ayaziwa
I-Car T-Cell Therapy	Amaseli we-Modified T Target cell cell	Ukusebenza okuphezulu kumdlavuza wegazi, okungenzeka ukwelashwa komdlavuza wamaphaphu	Isigaba sokuqala sokuthuthuka komdlavuza wamaphaphu, imiphumela emibi engaba khona

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uthole ukutholakala nokwelashwa.