Izibhedlela Zokwelashwa Kwezifiso ZaseGenetic Lung Lung Turnal Turnal Tarleval Turnalt Treatcher: Isiqondisi Esibanzi

Lo mhlahlandlela uhlinzeka ngesibukezo esibanzi se Ukwelashwa komdlavuza wegazi kwezakhi zofuzo. Izinketho zitholakala ezibhedlela eziholayo. Sihlola intuthuko yakamuva ezindaweni ezihlosiwe kanye ne-immunotherapy, zigqamisa ukubaluleka kwezinhlelo zokwelashwa ezenzelwe umuntu ngokususelwa kwiphrofayili yezakhi zofuzo. Funda ngokuthola izibhedlela ezihlonishwayo ezikhethekile Ukwelashwa komdlavuza wegazi kwezakhi zofuzo., Ukuqonda inqubo yokwelashwa, kanye nokuzulazula nezinselelo zalesi sifo esiyinkimbinkimbi.

Ukuqonda ukuguqulwa kwezakhi zofuzo emdlavuza wamaphaphu

Indima Yezakhi Zofuzo Ekuthuthukiseni Umdlavuza We-Lung

Umdlavuza wamaphaphu yisifo esiyinkimbinkimbi, kanye noguquko lwezakhi zofuzo kudlala indima enkulu ekukhuleni nasekuqulweni kwayo. Izinguquko ezahlukene zofuzo zingaholela ezinhlotsheni ezahlukahlukene zomdlavuza wamaphaphu, kuthonya ukusebenza kahle kwezindlela zokwelapha ezahlukahlukene. Ukuqonda lokhu kuguqulwa kubalulekile ekuthuthukiseni uhlelo lokwelashwa oluqondene nomuntu. Isibonelo, ukuguqulwa kwezakhi ze-EGR kuvame ukuqondiswa ekwelashweni okuthile. Ukukhonjwa kwalezi zinguquko kuvame ukuba yisinyathelo sokuqala ekunqumeni inkambo ephumelela kakhulu yesenzo Ukwelashwa komdlavuza wegazi kwezakhi zofuzo..

Ukuguqulwa kofuzo okujwayelekile emdlavuza wamaphaphu

Izinguquko ezimbalwa ezibalulekile zezakhi zofuzo zihlotshaniswa nomdlavuza wamaphaphu, kufaka phakathi i-EGFR, Alk, Ros1, Braf, nabanye. Ukuguqulwa ngakunye kunomthelela ekukhuleni nasekusakazekeni kwamangqamuzana omdlavuza ngokuhlukile. Ukuhlolwa kwezakhi zofuzo okuthuthukile kubalulekile ukukhomba ukuguqulwa okuthile okushayela umdlavuza wesiguli.

Izindlela ezihlosiwe zezakhi zofuzo

Izindlela zokwelapha ezihlosiwe ze-EGFR

Ukuguqulwa kwe-egfr kuvame ukubonwa ezigulini ezinomdlavuza wamaphaphu, ikakhulukazi labo abangakaze babheme. Izindlela ezintsha zokwelapha ezihlosiwe, njenge-tyrosine kinase inhibitors (TKIS), zenzelwe ngokukhethekile ukuvimba umsebenzi weprotheni ye-egfr eguqukayo, yehlisa umoya noma ukumisa ukukhula komdlavuza. Le mithi ivame ukubekezelelwa kahle, okuphumela ekuthuthukisweni okubalulekile ekusindeni okuphelele. Izibonelo ze-EGFR TKIS zihlanganisa iGefitinib, erlotinib ne-Afatiinib.

Alk, ros1, nezinye izindlela zokwelapha ezihlosiwe

Okufanayo kokuguqulwa kwe-EGFR, i-ALK ne-ROS1 RELENFACTESTS yinhloso engenzeka. Ama-TKI athile ayatholakala ukuqondisa lokhu kuguqulwa, okunikeza izinketho zokwelashwa ezisebenzayo zeziguli ngalezi zinguquko zofuzo. Ezinye izindlela zokwelapha ezihlosiwe zingaphansi kokuthuthukiswa kwezakhi zofuzo ezahlukahlukene, zinikeza ithemba ngemiphumela ethuthukisiwe ngaphakathi Ukwelashwa komdlavuza wegazi kwezakhi zofuzo.. Ukukhethwa kokuphathwa okufanele kuncike kakhulu ekucacisweni kwephrofayili yofuzo ngakunye.

I-Im-immunotherapy ekuvuthweni komdlavuza wezakhi zofuzo.

Ukubopha amandla amasosha omzimba

I-ImmunoSatherapy imele ukuphumelela okukhulu ekwelashweni komdlavuza. Lezi zindlela zokwelapha zisebenza ngokuvuselela amasosha omzimba wesiguli ukuze aqaphele futhi ahlasele amaseli omdlavuza. Ama-ejenti athile angu-ImmunoSapapy, anjengama-inhibistont, abonise impumelelo emangalisayo ekwelapheni iziguli ngezinguquko ezithile zofuzo emdlavuza wamaphaphu. Lawa ma-ejenti asetshenziswa kaningi ngokuhambisana nokwelashwa okuhlosiwe kwemiphumela efanelekile.

Ukukhetha indlela yokugoma ye-immunewootherapy efanele

Ukukhethwa kwe-immunotherapy kuncike ezicini ezahlukahlukene, kufaka phakathi uhlobo lokuguqulwa kwezakhi zofuzo, isigaba somdlavuza, kanye nempilo yesiguli yonke. Ukucatshangelwa ngokucophelela nokuhlola okwenziwe ngezifiso kubalulekile ekwenzeni izinqumo ezinolwazi mayelana nendlela engcono kakhulu ye-immunotherapy yesiguli Ukwelashwa komdlavuza wegazi kwezakhi zofuzo..

Ukuthola Isibhedlela Esilungile Sokwelashwa Komdlavuza Wokuguqulwa Kwezakhi Zofuzo Amaphaphu

Indlela yokukhetha isibhedlela esidumile

Ukukhetha Isibhedlela Esilungile kubaluleke kakhulu ngempumelelo Ukwelashwa komdlavuza wegazi kwezakhi zofuzo.. Funa izibhedlela ezinolwazi olunzulu ekwelapheni umdlavuza wamaphaphu, ikakhulukazi lezo ezinezinhlelo ezikhethekile ezigxile ekwelashweni ezihlosiwe ngokokwaneli kanye ne-immunotherapy. Ukutholakala kwamakhono wokuhlola izakhi zofuzo kanye nethimba elijwayelekile le-Oncologists, odokotela abahlinzayo, nabanye ochwepheshe nabo babalulekile. Cabanga ngezinto ezifana nokubuyekezwa kwesiguli, amanani empumelelo, kanye nekhwalithi yokunakekelwa ephelele enikezwayo.

Ukubaluleka kwendlela ye-multidisciplinary

Indlela Ehlukahlukene Ebandakanya i-Oncologists, odokotela abahlinzayo, izazi zezezimali, ama-radiologists kanye nabanye ongoti babalulekile ukuze baphumelele Ukwelashwa komdlavuza wegazi kwezakhi zofuzo.. Le ndlela yokubambisana ivumela ukuhlolwa okuphelele, ukuhlela ukwelashwa okwenziwe ngezifiso, kanye nokunakekelwa okuhlanganisiwe kulo lonke uhambo lwesiguli.

Ezigulini ezifuna ukunakekelwa okuthuthukile ngaphakathi Ukwelashwa komdlavuza wegazi kwezakhi zofuzo., cabanga ukucwaninga izikhungo ezifana ne I-Shandong Baafa Cancer Research Institute. Hlala uthintana nodokotela wakho ukuthola inkambo engcono kakhulu yezimo zakho.

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uthole ukutholakala nokwelashwa kwanoma yisiphi isimo sezokwelapha.