Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza

Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza Ingabe indlela ebhekiswe egxile egxile emshaweni ngqo kwisiza se-tumor, yandisa ukusebenza kwayo ngenkathi inciphisa imiphumela emibi ehleliwe. Le ndlela ithuthukisa imiphumela yokwelapha ngokuthuthukisa ama-bioavailabilielity wezidakamizwa ngaphakathi kwesimila nokunciphisa ukuvezwa kwezicubu ezinempilo, iqonde ukunikezwa kwe-chempotherad okuvame ukubandakanya ukuphathwa kwezidakamizwa, lapho umuthi ujikeleza kuwo wonke umzimba. Ngenkathi esebenza ngempumelelo ekubulaleni amaseli womdlavuza, le ndlela nayo ingalimaza izicubu ezinempilo, okuholela emiphumeleni emibi ebalulekile. Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza Ihlose ukunqoba lokhu kukhawulelwa ngokuletha abenzeli bezokwelapha ngqo ku-tumor microenvelonment.befits yokulethwa kwezidakamizwa okwenziwe endaweni Ukusebenza kahle okuthuthukisiwe: Ukugxilwa kwezidakamizwa okuphezulu endaweni yokugcina izidakamizwa kuholela ekubulaweni kweseli yomdlavuza. Ubuthi obuncishisiwe: Ukuncishiswa kokuvezwa okuhleliwe kunciphisa imiphumela emibi futhi kuthuthukise ikhwalithi yempilo yeziguli. Isenzo esiqondisiwe: Ivumela ukulethwa kwezidakamizwa ezingaba thile kakhulu ekuphathweni okuhleliwe. I-Bioavailability ethuthukisiwe: Kunqoba izithiyo ekulethweni kwezidakamizwa ngaphakathi kwesimila se-microenvironment.methods zamasu wokulethwa kwezidakamizwa okwenziwe ngezidakamizwa asetshenziselwa ukufeza Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza. Lezi zindlela zingahlukaniswa kabanzi njengoba: umjovo wokubopha umjovo oqondile ubandakanya ukuphathwa kwezidakamizwa ezingokomzimba ezinhlamsweni noma izicubu ezizungezile ezizungezile. Le ndlela ilula futhi ayibizi kakhulu, okwenza ilungele izinhlobo ezithile zomdlavuza, ikakhulukazi lezo ezitholakala kalula. Ukuze uthole intuthuko yakamuva nokunakekelwa kwesihawu ekwelashweni komdlavuza, vakashela I-Shandong Baafa Cancer Research Institute.Imishini Emadivayisi Emadivayisi, Njengama-Wafers, ama-Microchips, nama-Hydrogels, angabekwa ngokuhlinzwa ngaphakathi noma eduze kwesimila. Lawa madivayisi akhipha izidakamizwa esikhathini esinqunyelwe, enikeza ukwelashwa okuqhubekayo nokwenziwa kwasendaweni.catheter-based Deliverycatheter angasetshenziselwa ukuletha izidakamizwa ngqo kwizithasi zegazi noma ezinye izindlela. Le ndlela ilusizo ikakhulukazi ekwelapheni umdlavuza ezithweni zesibindi ezifana nesibindi noma i-brain.Nanoparticle-based Deliverynanoparkles iyizinhlayiya ezincane (1-100 NM) ezingalayishwa ngezidakamizwa futhi ezibhekiswe kumaseli womdlavuza. Lezi zinhlayiya zenzelwe ukukhetha ngokukhetha ama-tumors ngenxa yezakhiwo zazo ezihlukile kanye ne-vasculature evuzayo yezicubu zomdlavuza. Bangathuthuka kakhulu Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza ukwelashwa. Funda kabanzi mayelana namaNanoparticles.types omdlavuza ophathwe ngokulethwa kwezidakamizwa okwenziwe endaweniUkulethwa kwezidakamizwa okwenziwe ngomdlavuza Kuyahlolwa amakhansela ahlukahlukene, kufaka phakathi: ama-brain Cannimpbuntable Wafers aqukethe izidakamizwa ze-chemotherapy zikhombisile ukwelapha i-glioblastoma, uhlobo lwesimila sobuchopho. Isibonelo, ama-Gliadel Wafers, aqukethe i-Carmustine, afakwe ngqo emgodini wobuchopho ngemuva kokuvuselelwa kwesigcawu. Le ndlela isetshenziselwa ukwelapha ukwelapha i-hepatocellular carcinoma (HCC) .Prostate Cancerbrachytherapy ifaka ukufakwa kwembewu ethokozisayo kwi-prostate gland ukuletha ukwelashwa kwemisebe okwenziwe endaweni. Le ndlela iyasebenza ekwelapheni umdlavuza wesigaba sokuqala se-Prostate Prostate.Breastrate athuthukisa ama-nanoparticle asuselwa kumaseli womdlavuza we-nanoparticle ukuqondisa amaseli omdlavuza webele futhi anciphise ubuthi obuhlelekile Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza. Nazi izibonelo ezimbalwa eziphawuleka: ama-gliadel ama-wafers ezilimo ze-glioblastomaclical akhombisile ukuthi ama-gliadel wafers angathuthukisa kakhulu amanani okusinda ezigulini ezisanda kutholakala noma okuphindaphindwayo. Ucwaningo olushicilelwe kwi- * Journal of Clinical Oncology * Ukhombise inzuzo yokusinda ephakathi kwezinyanga ezimbalwa uma kuqhathaniswa ne-Placebo.Tace for Hepatocellular Carcinomace ukuthuthukisa amanani okusinda kanye nekhwalithi yempilo ezigulini ezingenakuvusa i-HCC. Ukuhlaziywa kwe-meta kwezifundo eziningi kutholakale ukuthi ukulutha kunciphise kakhulu ingozi yokufa ngokuqhathaniswa nokunakekelwa okusekelayo kuphela. Le khasi Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza Ibonisa ukuthuthuka okukhulu.Nanoparticles ezivivinyweni zomtholampilo zemitholampilo zihlola ukusetshenziswa kwezinhlelo zokulethwa kwezidakamizwa ezisuselwa kwi-nanoparticle ezinhlamvu zomdlavuza. Isibonelo, ukuqulwa kwecala lomtholampilo kuphenya ukusetshenziswa kwe-liposomal doxorubicin (doxil) yokwelashwa kwezinkomba zomdlavuza we-ovarians.future kanye nocwaningisi Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza kuvela ngokushesha. Ucwaningo oluqhubekayo lugxile ekuthuthukiseni izindlela ezintsha nezithuthukisiwe zokulethwa kwezindawo, kufaka phakathi izinhlelo ezinhle zezidakamizwa izinhlelo zokulethwa kwezidakamizwa zenzelwe ukukhipha izidakamizwa ekuphenduleni kwesisusa esithile, njenge-PHME, noma umsebenzi we-enzyme. Lezi zinhlelo zinganikeza ukulethwa kwezidakamizwa okuhloswe kakhulu nokulawulwa.Imimmunotherapy ukulethwa kwezidakamizwa okwenziwe nge-immunotherapy yindawo ethokozisayo yocwaningo. Ngokuletha ama-ejenti akhuthazayo wokuzivikela ngokuqondile ku-liconInveloNgomment, abacwaningi banethemba lokuthuthukisa ukusebenza kwe-immunotherapy.Imithi Medicinetailocong amasu wokulethwa kwezidakamizwa wezidakamizwa ezinesiguli esingesinye isiqondiso esibalulekile. Le ndlela eqondene nomuntu uqobo ingaholela ekwelashweni okusebenzayo kakhulu nokwenziwe kahle kobuthi. I-Shandong Baafa Cancer Research Institute egcizelela izinhlelo zokwelashwa ezenziwe ngezifiso ezisuselwa ocwaningweni olunqenqemeni. Funda kabanzi ngokuzibophezela kwethu ku-Canceway Researy Method Izindlela Zokuhlinzekela Okubi, ukuhlinzekelwa kwezifo ezifuywayo ezinqunyelwe ukuqondiswa kwe-chemother, kungafinyelela izicubu ezijulile zokuhlasela, ubungozi bezinkinga I-Tace yokulethwa komdlavuza okwenzelwe umdlavuza we-nanoparticle.Ukulethwa kwezidakamizwa okwenziwe ngomdlavuza Inikeza indlela ethembisayo yokuthuthukisa imiphumela yokwelashwa komdlavuza. Ngokugxila ezidakamizweni endaweni ye-tumor futhi unciphise ukuvezwa okuhlelekile, le ndlela inamandla okuthuthukisa ukusebenza ngempumelelo, yehlise ubuthi, futhi ithuthukise impilo yeziguli. Njengoba ucwaningo luqhubeka luthuthuke, singalindela ukubona amasu okulethwa kwezidakamizwa anwebekile futhi aphumelelayo aqhamuke, ekugcineni aholela emiphumeleni engcono yeziguli ezinomdlavuza.Ukuzikhulula: Le ndatshana yenzelwe izinjongo zolwazi kuphela futhi akufanele ibhekwe njengezeluleko zokwelashwa. Xhumana nochwepheshe wezempilo ofanelekayo kunoma yikuphi ukukhathazeka ngempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nohlelo lwakho lokwelashwa.Izinkomba:I-National Cancer InstituteUkucwaninga umdlavuza uk* I-Journal of Clinical Oncology *