I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle

Umdlavuza we-metastatic ongewona omncane weseli (MNSCLC) yisifo esiyinkimbinkimbi esidinga amasu okuthola ukwelashwa. Lo mhlahlandlela uhlinzeka ngesibukezo sezinketho zakamuva zokwelashwa, kufaka phakathi izindlela zokwelapha ezihlosiwe, ama-Im-i-Im-i-Chemotherapy, kanye nezilingo zemitholampilo, nokunika amandla iziguli zawo ngolwazi lokuthola izinqumo ezinolwazi.Umdlavuza we-metastatic ongewona omncane weseli, eyaziwa nangokuthi isigaba i-IV NSCLC, kusho ukuthi umdlavuza ususakaze emaphashini aye kwezinye izingxenye zomzimba. Izindawo ezijwayelekile ze-metastasis zifaka ubuchopho, amathambo, isibindi, nezindlala ze-adrenal. Ngenkathi umdlavuza we-metastatic ungaba inselelo enkulu ukwelapha, intuthuko yezinketho zokwelashwa ithuthukise kakhulu imiphumela kanye nekhwalithi yempilo yeziguli eziningi. Ukuxilongwa kusenesikhathi kubalulekile, futhi ungafunda kabanzi ngocwaningo lomdlavuza eShandong Bandong Baccer Research Institute.Stypes of non-cell cell ocwaningweni lomdlavuzo wezinhlobo ezimbili ze-NSCLC yi-Adenocarcinoma ezimbili kanye ne-squamous cell carcinoma. I-Adenocarcinoma uhlobo oluvame kakhulu futhi luvame ukwenzeka kubantu abangabhemi. I-squamous cell carcinoma ixhumeke kaningi ukubhema. Ezinye izinhlobo ezingaphansi kwezinto ezijwayelekile zifaka i-carcinoma enkulu ye-carcinoma enkulu ne-adenosquamous carcinoma. Ukutholwa okunembile kwe-subtype kubalulekile ekunqumeni indlela esebenza kahle yokwelashwa.Diagnosis kanye ne-stachdiagnosing I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Imvamisa kubandakanya inhlanganisela yokuhlolwa kokucabanga (i-CT Scans, i-PET SCANS, MRI), Biopsies, kanye nokuhlolwa kwama-molecular. Ukuhlolwa kwama-molecular kuhlaziya amaseli womdlavuza ukuze uthole izinguquko ezithile zofuzo noma ama-biomarkers angabhekiswa ekwelashweni oluthile. Isitabane sinquma ubukhulu bokusakazeka komdlavuza, ukusiza odokotela ukuthi basebenzise izinketho ze-Treatment Plan.Treat ments annong umdlavuza we-meng I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Imvamisa ihlelekile, okusho ukuthinta wonke umzimba. Izinhlobo zokwelashwa ezijwayelekile zifaka phakathi: Izidakamizwa zokwelapha ezihlosiwe ezihlosiwe zihlose ngqo ama-molecule athile (njengamaprotheni noma ufuzo) esiza amaseli womdlavuza akhula futhi asakaze. These therapies are often used in patients whose tumors have specific genetic mutations.EGFR InhibitorsEpidermal Growth Factor Receptor (EGFR) inhibitors are used for patients with EGFR mutations. I-EgthR EGRS HISICERS evamile ifaka: I-OSIMETININIBIB (TAGRIMCINE) I-ERLOTININIB (TARCEVA) GEFITINIBIB (TARSDA) Afatininib (Gilotrif) Le mishanguzo ivimba amaprotheni e-EGRS.I-ALK) Kusetshenziselwa iziguli ezihlehliswayo ze-ALK. I-ALK EMCK ENSITORS ifaka: Alectinib (Alecensa) Brigatinib (Alunbrig) Cergatinib (zyKadia) Crizotinib (zykadia) crizotinib (zykalia) crizotinib (xhuma) crizotinib (xhuma) crizotinib (xulkori) lezi zidakamizwa zivimba amaprotheni akwa-ALK, i-arving courses okuhlosiwe (i-braf, kwahlangana, i-Ntrk, futhi i-RET. Udokotela wakho we-oncologist uzonquma ukuthi umdlavuza wakho unazo noma yikuphi kwalezi zinguquko.Immunotherapyimmunotherapy izidakamizwa zisiza amasosha omzimba akho aqaphele futhi ahlasele amaseli umdlavuza. Lezi zindlela zokwelapha zivame ukusetshenziswa njengenketho yokwelashwa yomugqa wokuqala we I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle.Pd-1 kanye ne-PD-L1 inhibitorsSorsese Drug Block the PD-1 (Programled cell Deach Protein 1) noma i-PD-L1 (ehlelwe ngokushona kweLigand 1) Amaprotheni, asiza umdlavuza amaseli abuyisele amasosha omzimba. Ama-inhibitors ajwayelekile we-PD-1 ne-PD-L1 afaka: I-PD-L1 ENIVOLUMAB (i-Opdivo) i-Atezolumab (i-Opdivo) i-AteZulumab (i-Opdivo) i-AteZulumab (i-Imfinzi) - evame ukusetshenziswa ngemuva kwamakhemikhali eSiteji III NSCLC. I-protein ye-protein ye-protein engu-4 ye-CTLA-4 (i-Cytotoxic t-lymphocyte ehlobene neprotheni yamaprotheni, futhi esisiza amaseli omdlavuza abuyisele amasosha omzimba. I-Ipilimamab (Yervoy) iyinhlangano ejwayelekile ye-CTLA-4, kwesinye isikhathi esetshenziselwa inhlanganisela nge-PD-1 inhibitors.chemotherapychemothemothemothery izidakamizwa zisebenzisa amakhemikhali anamandla ukubulala ama-cell cell. Ngenkathi izindlela zokwelapha ezihlosiwe kanye nama-amcynotapapapies ziye zanda kakhulu, i-chemotherapy ihlala ihlala inketho yokwelashwa ejwayelekile, ikakhulukazi ngokuhlanganiswa nezinye izindlela zokwelapha. Izidakamizwa ezijwayelekile ze-chemotherapy ezisetshenziselwa I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Faka: Izidakamizwa ezisuselwa kuPlatinamu (i-Cisplatin, i-carboplatin) ama-tatanes (i-paclitaxel) i-gemcitabine (i-Gemzar) I-REMCITYANIDE (GEMzar) I-Radiants Therapyradiation therapy isebenzisa imisebe ephezulu kakhulu ukubulala umdlavuza. Imvamisa isetshenziselwa ukudambisa izimpawu ezinjengobuhlungu noma ukufushane komoya lapho umdlavuza usakaze ezicini ezithile njengethambo noma ubuchopho. Ingasetshenziswa futhi ukuphatha isimilo samaphaphu esiyisisekelo.Surgerysurgery ngokuvamile akuyona ukwelashwa okuyinhloko kwe I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle, kepha ingahle isetshenziswe ezimweni ezithile ukususa i-metastasis eyodwa, ikakhulukazi ebuchosheni noma ezinkangala ze-adrenal. Lokhu kuvame ukuba yingxenye yohlelo lokulawulwa kokwelashwa okuphelele.Cliinical izilingo lucwaningo lwezifundo ezihlola ukwelashwa okusha komdlavuza. Banikeza iziguli ukufinyelela kwezindlela zokwelapha ezisikiwe ezingatholakali kabanzi. Cabanga ngokuxoxa ngezinketho zesivivinyo semtholampilo nodokotela wakho. I-Shandong Baafa Cancer Research Institute ibambe iqhaza ngenkuthalo futhi ikhuthaza ukucwaninga komtholampilo Udokotela wakho angakusiza ukuphatha le miphumela emibi ngemithi nokunye ukunakekelwa okusekelwayo. Imiphumela emibi ejwayelekile ifaka ukukhathala, isicanucanu, ubuhlungu kanye nokulahleka kwezinwele. Kubalulekile ukuxhumana nanoma yimiphi imiphumela emibi oyithola eqenjini lakho lezempilo.Rognosis kanye nokusinda kwesilinganiso sokuqina I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Iyahlukahluka ngokuya ngezinto eziningana, kufaka phakathi isigaba somdlavuza, impilo yesiguli ephelele, kanye nokwelashwa okuthile okutholakele. Ngenkathi lesi sifo sivame ukuthuthuka, amanani okusinda athuthuke kakhulu ngokuthuthukiswa kwezindlela ezintsha zokwelapha. Xoxa nge-prognosist yakho ngayinye nge-Oncologist.Plalliative Carepalliative Care egxile ekunciphiseni izimpawu kanye nokwenza ngcono impilo yeziguli ezineziguli ezinezifo ezibucayi, kufaka phakathi umdlavuza wamaphaphu weMetastatic. Ingahlinzekwa kunoma yisiphi isigaba salesi sifo, futhi kuvame ukusetshenziselwa ukuhlangana nezinye izindlela zokwelapha. Ukunakekelwa kwePalliative kungasiza ukuphatha izinhlungu, ukufushane ukuphefumula, ukukhathala, nezinye izimpawu.Key Ukucatshangelwa kwezimpawu zokwelashwa zisho ukwelashwa okulungile kwe I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Isinqumo esiyinkimbinkimbi okufanele senziwe ngokubonisana ne-Oncologist yakho. Nayi eminye imininingwane ebalulekile: Imiphumela yokuhlola ama-molecular: Ukuqonda ukuguqulwa okuthile kofuzo noma ama-biomarkers kumaseli wakho womdlavuza kubalulekile ekunqumeni uma izindlela zokwelapha ezihlosiwe ziyindlela. Impilo yonke: Izinga lakho lonke kanye nokuqina lizothonya ukuthi yiziphi izindlela zokwelapha ezifanele. Imigomo yokwelashwa: Xoxa ngezinhloso zakho ukuze uthole ukwelashwa nodokotela wakho, noma ngabe kunwebeka ukusinda, ngcono ikhwalithi yempilo, noma zombili. Okuqhamuka uma udla imishanguzo: Qonda imiphumela emibi engaba khona yenketho yokwelashwa ngakunye nokuthi ingalawulwa kanjani. Izilingo Zomtholampilo: Bheka ukuthi ukuhlanganyela ekulingweni komtholampilo kulungile yini kuwe.Late inqubekela phambili e-LEP RASHRACTHRORCHTRACHRORTITE FIETH SOURCTION SACRABLERTRACTREMENT SACTRACTREMENT. Izindlela ezintsha nezindlela ezintsha zihlala zithuthukiswa. Ezinye zentuthuko yakamuva zifaka: I-Antibody-Drug Compionsetes (ADCS): Le mishanguzo ihlanganisa ukucaciswa kokwelashwa okuhlosiwe namandla okubulala amaseli we-chemotherapy. Ama-antibodies e-bispecicial: Lawa ma-antibodies ahlanganyela amaseli omzimba ukuqondisa nokubulala amaseli omdlavuza. Amasu we-radiation athuthukisiwe: Amasu anjengeStereotactic Word Radiation Therapy (SBTT) aletha imithamo ephezulu yemisebe kuya kumathumbu ngenkathi kunciphisa ukulimala kwezicubu ezizungezile I-Metastatic non omncane weseli lokwelashwa komdlavuza we-lungle Kungaba inselelo, kepha kunezinsizakusebenza eziningi zokusiza iziguli nemindeni yazo. Amaqembu okusekela, ukwelulekwa, kanye nemiphakathi eku-inthanethi kunganikeza ukusekelwa okungokomzwelo nezeluleko ezisebenzayo. Ukugcina impilo enempilo, kufaka phakathi ukudla okulinganiselayo nokuzivocavoca njalo, kungathuthukisa nekhwalithi yempilo. Ukuzikhulula: Lolu lwazi luhloselwe ulwazi olujwayelekile kanye nezinhloso zolwazi kuphela, futhi alwenzi izeluleko zezokwelapha. Kubalulekile ukuthintana nochwepheshe wezempilo ofanelekayo nganoma yiziphi izinkathazo zezempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo yakho noma yokwelashwa.Izinsizakusebenza zangaphandle:I-American Cancer Society - Ukwelapha umdlavuza wamaphutha we-non-omncaneCancer.Net - Umdlavuza wamaphaphu - iseli elingelona elincane - Izinketho zokwelashwaNational Comprehensive Cancer Network (NCCN) - Non-Small Cell Lung Cancer Guidelines for Patients (PDF)Izinkomba: Idatha nemininingwane eyethulwe isuselwa olwazini lwamanje lwezokwelapha futhi lutholwe kusuka ezinhlanganweni zokwelashwa ezihlonishwayo kusukela ngo-Okthoba 26, 2023.