Izinketho zokwelashwa komdlavuza weMetastatic Prostate

Umdlavuza we-metastatic Prostate umdlavuza we-prostate osatshalaliswe ngale kwezinye izigxobo ze-prostate eziya kwezinye izingxenye zomzimba. Izinketho zokwelashwa ziyahlukahluka ngokuya ngezinga lokusakazeka, ukwelashwa okwedlule, kanye nempilo yesiguli yonke. Ukwelashwa okujwayelekile kufaka phakathi ukwelashwa kwama-hormone, chemotherapy, i-immunotherapy, kanye nokwelashwa kwemisebe. Izindlela zokwelapha ezintsha ezinjenge-radiopharmaceuticals kanye nama-Parp inhibitors nawo asetshenziswa kakhulu. I-Shandong Baafa Cancer Research Institute inikezelwe ekuhlinzekeni izinketho zokucwaninga kanye nokwelashwa ukuze zithuthukise imiphumela yeziguli.Uqonde iMetastatic Prostate Cancer ProsProstate Cancer Umdlavuza weMetastatic Prostate Lapho lisakazeka kusuka kwendlala yesifebe kwezinye izindawo, imvamisa kakhulu amathambo, ama-lymph node, isibindi namaphaphu. Kubalulekile ukuqonda isigaba nebanga lomdlavuza ukuthola inkambo engcono kakhulu yesenzo. Ukuxilongwa kuvame ukufaka ukucabanga kokucabanga okufana namathambo okuskena, ama-CT scans, kanye nama-biopsies. Ukuguqulwa okuthile kwezakhi zofuzo nezinto ezihlobene nesimila microenvironment zingaba nomthelela kule nqubo. Isikolo esikhazimulayo futhi ukuba khona kwama-biomakers athile futhi kudlala indima ebalulekile ekubikezeleni ubungozi be-metastasis.andlaplard Izinketho zokwelashwa ze-Metastatic Pronsate Izinketho zokwelashwa zitholakala ngokuphatha Umdlavuza weMetastatic Prostate. Lokhu kuvame ukusetshenziswa ngokuhlanganiswa noma ngokulandelana ukwandisa ukusebenza kwe-auth.hormone Therapy (i-androgen dischivation therapy - i-adt) yezokwelapha (i-adt), ihlose ukwehlisa amazinga ama-hormone wesilisa (i-androgens) emzimbeni, okuphetha ukukhula kwamangqamuzana omdlavuza wesilisa. Lokhu kungatholakala ngokuhlinza i-castration (i-orchiectomy) noma ukubekwa kwezokwelapha kusetshenziswa ama-agonists we-LHRH agonists noma ophikisana naye. Imiphumela emibi ejwayelekile ifaka ukukhanya okushisayo, ukulahleka kwe-libido, ukungasebenzi kahle kwe-erectile, nokukhathala. I-ADT imvamisa ukwelashwa komugqa wokuqala Umdlavuza weMetastatic Prostate.Chemotherapychemothemothekom kufaka phakathi ukusetshenziswa kwezidakamizwa ukubulala umdlavuza amaseli. Imvamisa isetshenziswa lapho ukwelashwa kwe-hormone akusasebenzi kahle (umdlavuza we-prostate olwa nokungamelana nalokho - i-CRPC). Izidakamizwa ezijwayelekile ze-chemotherapy ezisetshenziselwa umdlavuza we-Prostate zifaka i-DoCoStaxel ne-cabahazitaxel. Imiphumela emibi ingafaka i-nausea, ukugabha, ukulahleka kwezinwele, ukukhathala, kanye nengozi eyandayo yokutheleleka. I-Shandong Baafa Cancer Research Institute Igcizelela ukuphatha imiphumela emibi yokwenza ngcono ikhwalithi ye-Life.Radiation therapyradiation therapy isebenzisa imisebe yamandla aphezulu noma izinhlayiya ukubulala amaseli omdlavuza. Ingasetshenziselwa ukwelapha i-prostate gland ngokwayo (ukwelashwa kwemisebe yangaphandle noma i-brachytherapy) noma ukukhomba amasayithi we-metastatic emathanjeni (kwangaphandle kwe-radiation therapy). Ukwelashwa kwemisebe kungasiza ukudambisa izinhlungu futhi kuthuthukise ikhwalithi yempilo. Imiphumela emibi incike endaweni ephathwayo kodwa ingafaka ukukhathala, ukucasuka kwesikhumba, kanye nezinkinga zamathumbu.Surgerysurgery, njenge-radical prostatectomy, isetshenziselwa kancane Umdlavuza weMetastatic Prostate. Kodwa-ke, kungahle kubhekwe ezimweni ezithile, njengokususa isimila esiyinhloko ukunciphisa izimpawu noma ukuhlanganiswa nezinye izindlela zokwelapha. Ukususwa Kwe-Metastatic LESIONSAYENZELWE YENZIWE.Newerer kanye neReventing Roundmesechsech entsha Izinketho zokwelashwa komdlavuza weMetastatic Prostate Uhlala uvela njalo, enikeza ithemba ngemiphumela ethuthukisiwe kanye nekhwalithi engcono yempilo. Nazi ezinye izindlela ezintsha: ama-radiopharmaceuticalsradicals yizidakamizwa eziletha imisebe ngqo kumaseli womdlavuza. I-radium-223 dichloride (xofigo) iyi-radiopharmaceutical esetshenziselwa ukwelapha ama-mone metastase ezigulini nge-CRPC. I-Lutetium-177 PSMA-617 ingenye i-radiopharmaceutical ehlose i-antigen eqondene ne-demostanet (PSMA), amaprotheni atholakala ebusweni bamaseli omdlavuza we-Prostate. Imiphumela emibi ingafaka ukucindezelwa kwamathambo kanye nokukhathala.Imimmunotherapyimmunotherapy ihlanganisa amandla amasosha omzimba okulwa nomdlavuza. SipUUUCEL-T (Provenge) ukwelashwa okungekho emthethweni okuvunyelwe nge-asymptomatic noma i-CRPC encane. Kubandakanya ukuqoqa amangqamuzana omzimba wesiguli, ukuwaguqula ukuze aqaphele amaseli omdlavuza we-Prostate, abese ebanikeza isiguli. I-Pembrolikumab, inhibitor yokuhlola, ingaba inketho yeziguli ezinokuguqulwa okuthile kwezakhi zofuzo noma ukungazinzi kwe-MicroSATellite ephezulu (MSI-H) .Perp Inhibitorspark inhibitors yizidakamizwa ezivimba ama-exyme e-PARP. Le mishanguzo ingasebenza ezigulini ezinezinguquko ezithile zofuzo, njenge-brca1 / 2 ukuguqulwa kwezakhi zofuzo. I-Olaparib ne-rucaparib yi-Parp inhibitors evunyelwe ukwelashwa kwe-CRPC. Imiphumela emibi ejwayelekile ifaka i-anemia, ukukhathala, kanye nausea. I-Shandong Baafa Cancer Research Institute ibambe iqhaza ngenkuthalo ocwaningweni oluhlola ukusetshenziswa kwamaphaphu inhibitors ngokuhlanganiswa nezinye izindlela zokwelapha. Ungafunda kabanzi ngeParp inhibitors ku- I-National Cancer Institute IwebhusayithiI-therapygegegegegegegegegegegegegegegegegegegegegegegegegegegeged isebenzisa izidakamizwa ezihlose ngqo ama-molecule athile ahilelekile ekukhuleni kweseli yomdlavuza kanye nokusinda. Izibonelo zifaka izidakamizwa ezivimbela ukusayina izindlela ezinjenge-PI3K / AKT / MTOR yendlela. Lezi zindlela zokwelapha zivame ukusetshenziswa ezivivinyweni zemitholampilo futhi zisaphenywa ngokusebenza kwazo ekwelapheni Umdlavuza weMetastatic ProstateAmasu wokuhlukunyezwa asuselwa esiteji sezifo kanye nezinto ezisengozini yokukhetha yokwelashwa kuncike ezintweni ezimbalwa, kufaka phakathi ubukhulu besifo, impilo yesiguli ephelele, kanye nokwelashwa kwangaphambilini. Ithebula elilandelayo lifingqa izindlela zokwelashwa okujwayelekile: Isiteji / Izingxabano Zokusetshenziswa Kwe-Metastatic - Umdlavuza We-Metastatic-Stearitive Personatic Adt + I-Enzalutamide), i-chemotherapy, noma ukuqulwa kwecala lokwelashwa. Umdlavuza we-metastate omelana ne-metastatic prostate prostate (CRPC),, i-androgen receptor inhibitors, ama-radiopharmarmaceuticals, immunotherapy, i-Parp inhibitorals (uma ikhona), noma ukuqulwa kwecala lomtholampilo. I-Bone Metastases radiation therapy, ama-radiopharmarmaceuticals, ama-bisphosphonate noma i-denosumab (ama-ejenti aqinisa amathambo). Ukuvivinywa kwemitholampilo kanye nezivivinyo ze-I-Exporimical zesikhathi esizayo kubalulekile ekwakheni ukwelashwa okusha nokuthuthukile kwe Umdlavuza weMetastatic Prostate. Iziguli zingacabanga ukubamba iqhaza ezivivinyweni zemitholampilo ukufinyelela ekwelashweni kokusika futhi zinikele ekucwaningweni kwezokwelapha. Ucwaningo oluqhubekayo lugxile ekuthuthukiseni ukwelashwa okuhlosiwe okusebenzayo okusebenzayo, ama-ackworeatapapies, kanye nokwelapha okuhlanganisiwe. I-Shandong Baafa Cancer Research Institute idlala indima ebalulekile ekwenzeni izivivinyo zemitholampilo futhi iqhubekise insimu ye-Prostate Cancerget. Ungaxhumana I-Shandong Baafa Cancer Research Institute Ngemininingwane ekuvivinyweni kwamanje kwemitholampilo kanye nezinketho zokwelashwa.Liva nge-Metastatic Prostate Cancerving nge Umdlavuza weMetastatic Prostate angethula izinselelo ezinkulu. Ukuphatha izimpawu, ukubhekana nemiphumela emibi, futhi ukulondolozela ikhwalithi yempilo yizici ezibalulekile zokunakekelwa. Amaqembu okusekela, ukwelulekwa, kanye nezinsizakalo zokunakekelwa kwezindawo eziphilayo zinganikeza usizo olubalulekile. Ukuxhumana okuvulekile nabahlinzeki bezokunakekelwa kwempilo kubalulekile ekwenzeni izinqumo ezinolwazi futhi uthole ukunakekelwa okungcono kakhulu okungenzeka.Conclusion Umdlavuza weMetastatic Prostate Ingabe isimo esibi, izinketho eziningi zokwelashwa ziyatholakala ukusiza ukuphatha lesi sifo, kuthuthukiswe ikhwalithi yempilo, futhi kwandiswe ukusinda. Ukuhlala unolwazi ngentuthuko yakamuva ekwelashweni futhi usebenza ngokubambisana nethimba labaningi labachwepheshe bezokunakekelwa kwempilo kubalulekile ekwenzeni izinqumo ezinolwazi futhi uthole ukunakekelwa okungcono kakhulu. I-Shandong Baafa Cancer Research Institute izimisele ukunakekela ukunakekelwa okuphelele nokuqhubekisela phambili inkambu yocwaningo lwe-Prostate Cancer and Treatment.