Ukwelashwa komdlavuza omusha wamaphaphu

Ukuthuthuka kwakamuva ku Ukwelashwa komdlavuza omusha wamaphaphu Nikeza amanani athuthukisiwe okusinda kanye nekhwalithi yempilo yeziguli. Lokhu kufaka phakathi izindlela zokwelapha ezihlosiwe, ama-ackwoctockapapies, namasu athuthukisiwe okuhlinza. Ukuqonda lezi zinketho kungahlomisa iziguli nemindeni yazo ukwenza izinqumo ezinolwazi kanye nabahlinzeki babo bezempilo. Le ndatshana inikezela ngesibukezo sezindlela zakamuva zokuphumelela kanye nezindlela zokwelashwa ezitholakalayo.Undlela oqonda umdlavuza wamaphaphu kanye nesidingo somdlavuza omusha wezokwelapha uhlala kuyinselelo enkulu yezempilo emhlabeni wonke. Kubalulekile ukuqonda izinhlobo ezahlukene zomdlavuza wamaphaphu nezici ezifaka isandla ekuthuthukisweni kwayo. Ukwelashwa kwendabuko okufana ne-chemotherapy kanye nokwelashwa kwemisebe kube nemikhawulo, kugcizelela isidingo esiphuthumayo se Ukwelashwa komdlavuza omusha wamaphaphu Amasu we-Sythread.typpes eLung Cancerthe izinhlobo ezimbili eziphambili yilezi: Umdlavuza we-cell ongelona omncane (NSCLC): Lolu uhlobo oluvame kakhulu, accounting cishe ama-80-85% wamacala omdlavuza wamaphaphu. Ama-subtypes afaka i-adenocarcinoma, i-squamous cell carcinoma, kanye ne-carcinoma enkulu ye-carcinoma. Umdlavuza omncane weseli (i-SCLC): Lolu hlobo alujwayelekile futhi luvame ukukhula futhi lusakaze ngokushesha okukhulu kune-NSCLC.Breakthroughs ekwelashweni okuhlosiwe kokwelashwa okusasele kwamaphaphu a Ukwelashwa komdlavuza omusha wamaphaphu Lokho kugxile kuma-molecule athile ahilelekile ekukhuleni kweseli yomdlavuza kanye nokusinda. Ngokungafani ne-chemotherapy, ehlasela wonke amaseli ahlukanise ngokushesha, izindlela zokwelapha ezihlosiwe zihlose ukumbulala ngokukhetha amaseli omdlavuza ngenkathi zisindisa abanempilo. Lokhu kuvame ukuholela ekuvumeni okumbalwa kwe-Exffess.emmon okuhlosiwe kanye nokwelashwa okuhlosiwe okuhlosiwe manje sekuvunyelwe ukusetshenziswa ezinhlotsheni ezithile ze-NSCLC. Lezi zindlela zokwelapha zivame ukuqondisa ukuguqulwa kwezakhi zofuzo ezifana ne-EGFR, ALK, Ros1, Braf, Met, neNtrk. I-Target Isibonelo Sokuthola izidakamizwa i-NSCLC EGRR OSFERTINIB (Tagrisso) NSCLC nge-EGFR Mutetions Alk Alectinib (Alecensa) NSCLC nge-Alk RelectAngelib (Rozlytrek) NSCLC nge-Ros1 Relecrangetions Source: I-American Cancer SocietyIqhaza le-biomarker testngengekuqala ukwelashwa okuhlosiwe, ukuhlolwa kwe-biomarker kubalulekile. Lokhu kuhlola kufaka ukuhlaziya isampula yesimila sesiguli ukukhomba ukuguqulwa okuthile kwezakhi zofuzo noma amaprotheni ama-detein. Imiphumela yokuhlolwa kwe-biomarker isiza odokotela babone ukuthi isiguli kungenzeka sizuze ekwelashweni okuthile okuhlosiwe. Le khasi I-Shandong Baafa Cancer Research Institute Igcizelela ukubaluleka kokuxilongwa okuqondile kokwelashwa okusebenzayo. Ukwelashwa komdlavuza omusha wamaphaphu. Le ndlela isebenza ngokuvuselela amasosha omzimba wesiguli ukuze aqaphele futhi ahlasele amaseli umdlavuza. Izidakamizwa ze-ImmunoSapapy, ezinjengezinhlangothi zokuhlola, amaprotheni avimba amasosha omzimba ekuhlaseleni amaseli omdlavuza we-FunctcoMon izidakamizwa ezisetshenziswayo ezisetshenziswayo zomdlavuza wamaphaphu zifaka: I-PD-1 inhibitors: I-Pembrolikumab (Keytruda), Nivolumab (Opdivo) I-PD-L1 inhibitors: I-AtezoLiZumab (Tecentriq), Durvalumab (Imfinzi) I-CTLA-4 inhibitors: IPILILAMAB (Yervoy) (evame ukusetshenziswa ngokuhlanganiswa ne-PD-1 Ngubani) Ngubani umuntu ozongenela ukhetho lwe-immunotherapapy? I-PD-L1 iyiprotheni engasiza amaseli womdlavuza abuyisele amasosha omzimba. Iziguli ezinenkulumo ephezulu ye-PD-L1 kungenzeka ukuthi ziphendule nge-immunotherapy. Isazi se-oncologist sezokwelapha sizohlola ngokucophelela isiguli ngasinye ukuthola ukuthi i-immunotherapy kufanelekile.Ezinqubo zokuhlinzwa ezifanele e-Lung Cancer Cally Tempenturgery ihlala iyingxenye ebalulekile ye Ukwelashwa komdlavuza omusha wamaphaphu, ikakhulukazi i-NSCLC yesigaba sokuqala. Intuthuko ngamasu okuhlinza aholele ezinqubweni ezingahlaseli futhi zithuthukisiwe imiphumela ethuthukisiwe yokuhlanza izindlela, ezinjenge-thoracoscopic ukuhlinzwa (ama-vams) kanye nokuhlinzwa kwamarobhothi, vumela ama-sorotic ahlinzayo, avumele ama-tulars ngokusebenzisa imithamo emincane. Lawa masu anikela ngezinzuzo eziningana ngaphezulu kokuhlinzwa okuvulekile kwendabuko, kufaka phakathi izinhlungu ezingaphansi, izibhedlela ezifushane zokutakula, i-Steract Times Sound Radiotherapy (SBTT iyindlela eqondile yokwelashwa kwamaphaphu ezigulini ezingafanelekile zokuhlinzwa ezifanele. I-SBT ihambisa imithamo ephezulu yemisebe ibe yisimila ngenkathi inciphisa ukuvezwa kwezindlela ezinempilo ezizungeze izicubu ezinempilo) zokulashwa okuphezulu kwamacala amaningi, indlela ephumelela kunazo zonke Ukwelashwa komdlavuza omusha wamaphaphu kufaka phakathi ukuhlanganisa izindlela zokwelapha ezahlukahlukene. Isibonelo, iziguli zingathola i-chemotherapy zilandelwe ukuhlinzwa, noma ukwelashwa okuhlosiwe kuhlangene ne-immunotherapy. Inhlanganisela ethile yokwelashwa izoncika esimweni esithile sesiguli .Ukubaluleka kwezilingo zokuvivinya izilingo zidlala indima ebalulekile ekuthuthukisweni kwe Ukwelashwa komdlavuza omusha wamaphaphu amasu. Lezi zivivinyo zihlola ukuphepha nokusebenza kahle kwezidakamizwa ezintsha kanye nezindlela zokwelashwa. Iziguli ezibamba iqhaza ezivivinyweni zemitholampilo zingase zifinyelele ekutholeni ukwelashwa okuma eceleni okungatholakali kabanzi. Cabanga ngokuxoxa ngezinketho zesivivinyo semtholampilo ne-Oncologist yakho. Imininingwane mayelana nemikhondo yemitholampilo ephathelene nocwaningo lomdlavuza ingatholakala ku I-Shandong Baafa Cancer Research Institute Iwebhusayithi.Living nge-LEP RACER: Ukuxilongwa komdlavuza wesengezo kanye ne -IROPA LAMAHLUKO kungaba nzima. Kubalulekile ukufuna ukusekelwa ochwepheshe bezokunakekelwa kwempilo, umndeni, abangane kanye namaqembu okusekelana. Izinhlangano eziningi zinikeza izinsiza kanye nezinsizakalo ukusiza iziguli nemindeni yazo zibhekane nezinselelo zokuphila nenqubekela phambili yamaphaphu.Conclusishonification. Ukwelashwa komdlavuza omusha wamaphaphu eminyakeni yakamuva. Izindlela zokwelapha ezihlosiwe, ama-accunotherapies, namasu athuthukisiwe okuhlinza anikeza ithemba elisha leziguli ezinomdlavuza wamaphaphu. Ngokuhlala unolwazi ngentuthuko yakamuva futhi usebenza ngokubambisana nethimba labo lezempilo, iziguli zingenza izinqumo ezinolwazi futhi zithuthukise amathuba awo okusinda kanye nekhwalithi yempilo.