Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4

Isigaba 4 Umdlavuza wamaphaphu, owaziwa nangokuthi umdlavuza wamaphaphu we-metastatic, uveza izinselelo ezibalulekile. Kodwa-ke, ucwaningo oluqhubekayo kanye nokuthuthuka kwezinketho zokwelashwa kunikeza ithemba nangekhwalithi yempilo ethuthukisiwe. Lo mbhalo uhlola okwakamuva Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4, ukumboza izindlela zokwelapha ezihlosiwe, ama-accunotatapies, izivivinyo zemitholampilo, namasu wokunakekelwa asekelwayo. Lesi sigaba sidinga indlela ephelele yokwelashwa yokuphatha lesi sifo nezimpawu zayo. Ngeminye imininingwane kanye nentuthuko yocwaningo, vakashela I-Shandong Baafa Cancer Research InstituteIzimpawu ze-SPASymymmon zesiteji 4 Umdlavuza wamaphaphu ziyahlukahluka ngokuya ngendawo yama-metastases, kepha kungafaka: Ukuncipha kokuncipha kwesifuba sokunciphisa isisindo se-heather noma ukufakwa ngaphakathi Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4Izindlela zokwelapha ezihlosiwe zinezidakamizwa ezihlose izinhlobo ezithile zofuzo, amaprotheni, noma indawo yezicubu ezinomthelela ekukhuleni komdlavuza nokusinda. Lezi zindlela zokwelapha zenzelwe ukuhlasela amaseli umdlavuzelo ngokuqondile, ukunciphisa ukulimala kumaseli ajwayelekile.Examples kufaka phakathi: Isib. Isetshenziselwa amaphaphu amaphaphu nge-EGFR ukuguqulwa. Izidakamizwa ezijwayelekile zifaka i-erlotinib, i-gefitinib, i-afatiinib, ne-ostertinib. I-Alk inhibitors: Isetshenziselwa amaphaphu amaphaphu ngokuhleleka kabusha kwe-ALK. Izibonelo zifaka crizotinib, alectin, ceritinib, kanye ne-brigatinib. I-Braf inhibitors: I-Dabrafenib neTrametinib zisetshenziselwa amaphaphu amaphaphu nge-braf v600e ukuguqulwa kwezakhi zofuzo. QAPHELA: I-Selpercatrib nePragleTinib isetshenziselwa amaphaphu umdlavuza nge-RET fusions.Indlela yokwelashwa okuhlosiwe incike ekuguqukeni kofuzo okuthile okukhonjwe kwisimilo yesiguli ngokuhlolwa kwesiguli. Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4 Zivela njalo ngocwaningo oluqhubekayo oluvela ezikhungweni ezifana ne-Shandong Bandong Baccer Research Institute.Immunotherapyimmunotherapy ikhulisa izivikelo zemvelo zomzimba ukulwa nomdlavuza. Isebenza ngokuvuselela amasosha omzimba ukubona nokuhlasela umdlavuza ama-cellm.comon izinhlobo ze-immunotherapy ezisetshenziselwa umdlavuza we-STATE 4 LUPL zifaka: Ukuhlola inhibitors: Le mishanguzo ivimba amaprotheni avimbela amasosha omzimba ekuhlaseleni amaseli omdlavuza. Izibonelo zifaka i-pembrolikumab, nivolumab, i-atezolikumab, neDurvalumab.Immunotherapy zingasetshenziswa zodwa noma zihlangane nge-chemotherapy noma ukwelashwa okuhlosiwe. Ukusebenza kwayo kuyahlukahluka phakathi kweziguli, kanye ne-biomarkers efana nenkulumo ye-PD-L1 ingasiza ukubikezela impendulo. Isikhungo Sokucwaninga Nge-Baafa Cancer Research sibambe iqhaza ngokujulile ekucwaningweni kwalapha ama-Therepapimes Kubandakanya ukusebenzisa izidakamizwa ukubulala amaseli womdlavuza kuyo yonke imizimba emihle) Izilingo ze-Clinical Climiclimonical ziyizifundo zokucwaninga ezivivinya Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4. Ukubamba iqhaza esivivinyweni somtholampilo kunganikeza ukufinyelela kwezindlela zokwelapha ezisikiwe ezingatholakali kabanzi. Izinzuzo zokubamba iqhaza ezivivinyweni zemitholampilo: Ukutholakala kwezindlela zokwelashwa kwenoveli ekucwaningweni komdlavuza ukucwaninga okusondelene nokunakekelwa kwabanakekeli kungasesha izivivinyo zemitholampilo nge-National Cancer Institute (NCI) noma umphakathi waseMelika. Cabanga ukuhlola amathuba emtholampilo ngokusebenzisa I-Shandong Baafa Cancer Research Institute.Suportive Care and Palliative careManaling Izimpawu kanye nokwenza ngcono ikhwalithi yokunakekelwa kwempilo, okwaziwa nangokunakekelwa kwe-palliative, kugxile ekunciphiseni izimpawu kanye nokwenza ngcono izikejana zokuphila ngomdlavuza we-Stage 4 Lung. Kuyingxenye ebalulekile yohlelo lokwelashwa futhi lunganikezwa kanye nezinye izindlela zokwelapha) zibandakanya ukunakekelwa kokuphakanyiswa kwezokwelapha kanye ne-Persolological Support Team Surdidatory Team of Heatultcare Team of HealtiDare Team of Healtidisciplinary Team of Healtidisciplinary Team of Healtidiscilinare Team of Healtidicres of Healthcare Cask. Leli qembu lingafaka: izazi ze-oncologists punmonmolosts radiation incogists Oncoloons Surgeons Careons Cares Offerences Offerents Offerents Offerents, kepha bafuna ukuhlala unolwazi ngeziguli ezi-4 zamaphaphu zinikeza izinsizakusebenza ezigulini futhi Abanakekeli, kufaka phakathi: I-American Lung Association Lung Cancer Christian Prenication Consance Dection ConserCon Consances ihlala ixilongwa kakhulu, ukunakekelwa kokwelashwa kanye nokunakekelwa kwempilo kuthuthukile kakhulu ezigulini. Izindlela zokwelapha ezihlosiwe, ama-accunotherapies, kanye nezilingo zemitholampilo zinikezela Ukwelashwa okusha kwesigaba somdlavuza wamaphaphu 4 futhi unethemba ngekusasa elingcono. Kubalulekile ukusebenzisana eduze nethimba elijwayelekile ukuthuthukisa uhlelo lokwelashwa oluqondene nomuntu uqobo olubhekela izidingo nezinhloso zomuntu ngamunye. Isikhungo Sokucwaninga Nge-Shendong Baccer Cancer Researvel sizibophezele ukuqhubekisela phambili insimu ngocwaningo olusha nokunakekelwa kwesihawu.