Ukulethwa kwezidakamizwa okulawulwayo: Isihloko esiphelele se-RegideTis sinikeza umbono ophelele we Ukukhishwa kwezidakamizwa okulawulwayo Izinhlelo, ukuhlola izindlela zabo, izinhlelo, izinzuzo, nezinselelo. Sihlela ezinhlotsheni ezahlukahlukene ze Ukukhishwa kwezidakamizwa okulawulwayo Izinhlelo, ukucatshangelwa kwazo design, kanye nezitayela zesikhathi esizayo kule nkambu yokuvela ngokushesha. Funda ngomthelela walezi zinhlelo ekutholeni iziguli kanye nokusebenza kahle kwezokwelapha.

Ukunikezwa kwezidakamizwa okulawulwa: umhlahlandlela ophelele

Ukukhishwa kwezidakamizwa okulawulwayo (Cardd) Izinhlelo zenzelwe ukuletha ama-ejenti wezokwelapha ngesilinganiso esinqunyelwe kusengaphambili kanye nesikhathi esibekiwe. Lokhu kuqhathaniswa nezindlela ezijwayelekile zokulethwa kwezidakamizwa, lapho umuthi ukhishwa ngokushesha ungene egazini, uvame ukuholela emazingeni ezidakamizwa aguquguqukayo kanye nemiphumela emibi engaba khona. I-Cardd inikeza izinzuzo ezinkulu ngokwenza ngcono ukusebenza kwezidakamizwa, ukunciphisa imiphumela emibi, kanye nokwenza ngcono ukuhambisana kwesiguli. Lo mhlahlandlela onemininingwane uhlola isimo esahlukene sobuchwepheshe be-CardD, izinhlelo zabo, kanye namathemba esikhathi esizayo.

Izindlela zokukhishwa okulawulwayo

Izinhlelo ezilawulwa - ezilawulwa

Izinhlelo ezilawulwa - ezilawulwa zisebenzisa ulwelwesi olungavunyelwe khona noma matrix ukulawula ukukhishwa kwesidakamizwa. Lesi sidakamizwa sidabula ngolwelwesi olulawulwa, oluchazwe yizinto ezinjengokuthi ukuqina kwe-membrane, i-solubity yezidakamizwa, kanye ne-geometry yohlelo. Izibonelo zifaka amasistimu wezinsuku kanye nama-matric monolithic. Lezi zinhlelo zivame ukuba lula ukuklama nokwakha, ukuzenza zisetshenziswe kabanzi kwizicelo ezahlukahlukene.

Izinhlelo ezilawulwa ukuguguleka

Izinhlelo ezilawulwa ukuguguleka zikhipha umuthi njengoba uhlelo uqobo lwalo luhlazisa noma lukhumule ngokuhamba kwesikhathi. Izinga lokukhishwa kwezidakamizwa lincike ngqo ngesilinganiso sokuguguleka, esingathonywa yizici ezifana ne-PH, lokushisa, kanye nokwakheka kohlelo. Le ndlela inikezela ukukhishwa okuqhubekayo kwezikhathi ezengeziwe.

I-Biodegradable Polymers ekukhishweni okulawulwayo

I-Biodegradable Polymers, efana ne-polylactic-co-glycolic acid (PLGA) ne-polycapropactone (PCL), zisetshenziswa kaningi Ukukhishwa kwezidakamizwa okulawulwayo izinhlelo. I-Biocomtic yabo namazinga wokuwohloka alawulayo abenza balungele izinhlelo ezahlukahlukene, kufaka phakathi amadivayisi wokulethwa kwezidakamizwa afakiwe. Ukukhetha kwe-polymer kuncike kuphrofayela yokukhishwa oyifunayo kanye nesicelo. Isibonelo, i-PLGA inikeza ukucekelwa phansi okusheshayo uma kuqhathaniswa ne-PCL, ukuvumela ukukhishwa okusheshayo kwesidakamizwa. Le khasi Umtapo wolwazi kazwelonke wezokwelapha ihlinzeka ngocwaningo olubanzi ngale ndaba.

Izinhlobo zezinhlelo zokukhishwa kwezidakamizwa ezilawulwayo

I-CRDD ifaka amahlelo abanzi wezinhlelo, ezihambisana nezidingo ezithile zokwelapha. Ezinye izibonelo ezivelele zifaka:

• Amaphampu angenakufinyeleleka: Lawa madivayisi aletha izidakamizwa ngesilinganiso esinembile sezikhathi ezengeziwe, ezivame ukusetshenziselwa izimo ezingamahlalakhona ezidinga umuthi oqhubekayo.
• Iziqeshana ze-Transdermal: Le mikhakha ikhipha izidakamizwa esikhunjeni, ihlinzeka ngokukhululwa okuqhubekayo ezinsukwini noma amasonto amaningi, izibonelo zifaka iziqeshana ze-nicotine kanye neziqu ze-Fentanyl zokulawulwa kwezinhlungu.
• Izakhiwo ezilawulwa ngokulawulwa ngomlomo: Lezi zinhlaka, ezinjenge-capsule kanye namathebulethi, zinikezela ukukhishwa kwezidakamizwa okunwetshiwe ngaphakathi kwepheshana lesisu.
• Ama-Microsrones ajova kanye nama-nanoparticles: Lezi zinhlelo zinikezela ukulethwa kwezidakamizwa okuhlosiwe nokukhululwa okuqhubekayo, okuvame ukusetshenziswa ekwelashweni komdlavuza kanye nezinye izinhlelo zokusebenza ezidinga isenzo sezidakamizwa ezakhiwe.

Izinzuzo zokulethwa kwezidakamizwa ezilawulwayo

Ukukhishwa kwezidakamizwa okulawulwayo Inikeza izinzuzo eziningana ezibalulekile:

• Ukuthuthuka okwenziwe ngcono ngokwelashwa ngenxa yamazinga wezidakamizwa angaguquki.
• Imvamisa encishisiwe ye-dosing, ukuthuthukisa ukuhambisana kwesiguli.
• Imiphumela emibi encishisiwe ngokugwema ukugxila kwe-peak plasma.
• Ukulethwa kwezidakamizwa okuhlosiwe ezicubu ezithile noma izitho ezithile.
• Isikhathi esandisiwe sesenzo sezidakamizwa.

Izinselelo Nezitayela Ezizayo

Naphezu kwezinzuzo, izinselelo zihlala ku-CRDD. Lokhu kufaka phakathi:

• Izinqubo eziyinkimbinkimbi zezinqubo nezinqubo zokukhiqiza.
• Amandla okuqhuma kokuqhuma noma ukucekelwa phansi ngaphambi kwesikhathi.
• I-BioCOMTIBIBIBIBIBIBIBIBIBIBIBIBIBIBIBIBIBIBE.
• Ukusebenza kwezindleko.

Izitayela zesikhathi esizayo zigxile ekuthuthukiseni izinhlelo eziyinkimbinkimbi, kufaka phakathi:

• Izinhlelo zokuvuselela izidakamizwa eziphendulayo.
• Amasu okuqondisa athuthukisiwe.
• Ngenzelwe Ukukhishwa kwezidakamizwa okulawulwayo isondela.
• Izinto ze-biofegradable ne-biocomospeate.

Izicelo zokulethwa kwezidakamizwa ezilawulwayo

Ukukhishwa kwezidakamizwa okulawulwayo Ithola izinhlelo zokusebenza ezindaweni ezahlukahlukene zokwelapha, kufaka phakathi:

• I-Cancer Therapy: Ukulethwa okuhlosiwe kwama-chemotherapeic agents.
• Ukuphathwa kobuhlungu: Ukukhishwa okuqhubekayo kwe-analgesics.
• Ukwelashwa Kwe-Hormone Replacement: Amazinga we-hormone angaguquki.
• Isifo senhliziyo: Ukukhishwa okulawulwa kwezidakamizwa ezi-antihytensive.
• I-Ophthalmology: Ukulethwa kwezidakamizwa okwenziwe esweni.

Ukucwaninga okwengeziwe kanye nentuthuko ku Ukukhishwa kwezidakamizwa okulawulwayo zibalulekile ukubhekana nezidingo ezingathandeki ekunakekelweni kwezempilo kanye nokwenza ngcono imiphumela yeziguli. Umsebenzi oqhubekayo ezikhungweni ezifana neShandong Bandong BacceCancer Research Institute (https://www.baofahospital.com/) Iyaqhubeka nokucindezela imingcele yale nkambu.

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