Ukwelashwa komdlavuza wamaphaphu amancane

Ukwelashwa komdlavuza weseli okungewona omncane (NSCLC) Izinketho zihlukahlukene futhi zincike esiteji, ama-subtype, kanye nezinto ezifundeni. Ukwelashwa okujwayelekile kufaka phakathi ukuhlinzwa, ukwelashwa kwemisebe, i-chemotherapy, ukwelashwa okuhlosiwe, kanye ne-immunotherapy, evame ukusetshenziswa ngokuhlanganiswa. Lo mhlahlandlela uhlola inketho ngayinye ngokuningiliziwe, okusiza ukuthi uqonde amathuba futhi wenze izinqumo ezinolwazi ngokubonisana nethimba lakho lezokunakekelwa kwempilo.Ukuqonda okungelona omncane umdlavuza wama-lung (NSCLC) yini i-NSCLC?Umdlavuza we-cell ongewona omncane (NSCLC) uhlobo oluvame kakhulu lomdlavuza wamaphaphu, accounting cishe ama-80-85% awo wonke amacala omdlavuza wamaphaphu. Yigama lesambulela elifaka ama-subtypes amaningana, i-adenocarcinoma, i-squamous cell carcinoma, kanye neseli elikhulu le-carcinoma.nclc stalingthe isigaba se-NSCLC ibalulekile ekunqumeni indlela engcono kakhulu yokwelashwa. Lesi siteji sinqunywa ngosayizi nendawo yendawo yesimila, noma ngabe siye sasakazeka kwizindlela ze-lymph eziseduze, nokuthi ngabe zihlelwe ngezinketho ezikude ze-organs.reastrement for NSCLCsuryerygery zivame ukwelashwa okuyinhloko kwe-NSCLC yesigaba sokuqala. Umgomo ukususa isimila nanoma yiziphi izimbotshana ze-lymph eziseduze ezingaqukatha umdlavuza. I-Lobectomy: Ukususwa kwe-lobe yonke yamaphaphu. Pneumonicyy: Ukususwa kwephaphu lonke. Ukuvuselelwa kwe-Wedge: Ukususwa kwesiqephu esincane, esimise okwenziwe nge-wedge. I-Segmetectomy: Ukususwa kwengxenye yamaphaphu, elikhudlwana kune-wedge resection kodwa lincane kune-lobectomy.Qaphela: Ukuhlinzwa kungenzeka kungabi yindlela yeziguli ezine-NSCLC ethuthukisiwe noma lezo nezinye izimo zezempilo ezenza ukuhlinzwa kwezempilo enobungozi kakhulu kuyingozi kakhulu. Ingasetshenziswa ukwelapha i-NSCLC ngezindlela eziningi: Ukwelashwa kwemisebe yangaphandle yangaphandle (EBRT): Imisebe ihanjiswa emshinini ngaphandle komzimba. Ukwelashwa kwemisebe yemisebe yeStereotactic (SBTT): Uhlobo olunembile kakhulu lwe-EBRT olunikezela umthamo omkhulu wemisebe endaweni encane. Imvamisa isetshenziselwa umdlavuza wamaphaphu wokuqala lapho ukuhlinzwa kungenzeki. Brachytherapy: Izinto ezinemisebe zibekwe ngqo emsakazweni noma eduze kwezokwelapha zeTumor.Radiation zingasetshenziswa zodwa noma zihlanganiswe nezinye izindlela zokwelapha, ezinjenge-chemotherapy. Thina at I-Shandong Baafa Cancer Research Institute Qonda ukubaluleka kokuhlanganisa ukwelashwa kwemiphumela emihle. I-BAOFA ingumholi ekunakekelweni komdlavuza okuhlangene kwe-Cancer.chemotherapychemothemothemothemothemy isebenzisa izidakamizwa ukubulala umdlavuza amaseli emzimbeni wonke. Imvamisa isetshenziselwa ukwelapha i-NSCLC ethuthukisiwe noma ukuvikela umdlavuza ukuthi ahlale endabeni ngemuva kokuhlinzwa. Izidakamizwa ezijwayelekile ze-Chemotherapy ze-NSCLC zifaka: I-Cisplatin Carboplatin pemetrexped doncetaxel paclitaxelchemorothemy imvamisa inikezwe ngemijikelezo, ngezikhathi zokwelashwa ezilandelwa yizikhathi zokuphumula. Imiphumela emibi ingahluka ngokuya ngezidakamizwa ezisetshenzisiwe kanye nokwelashwa kweziguli ngazinye zezokwelapha zisebenzisa izidakamizwa ezibhekise ama-molecule athile athinteka ekukhuleni kwamaseli womdlavuza kanye nokusinda. Le mishanguzo ivame ukusebenza ngempumelelo futhi inemiphumela emibi embalwa kune-chemotherapy. Izindlela zokwelapha ezihlosiwe zivame ukuba yiziguli ezinokuguqulwa okuthile kwezakhi zofuzo. Okuhlosiwe okujwayelekile kufaka: EGFR: Ukukhula kwe-Epidermal Factor Receptor ALK: I-anaplastic lymphoma kinase Ros1: Ros1 proto-oncogene receptor tytrosine kinase Braf: B-raf proto-oncogene, i-serine / threenine kinase Ntrk: I-Neurotrophic Tylosine Receptor Kinaseexamps yezidakamizwa zokwelapha ezihlosiwe ezisetshenziselwa i-NSCLC zifaka: Gefitrib (i-Iressa) erlotinib (Tarceva) i-CRIMTiniB (i-Alecensa) i-Alectinib (Alecensa) Alectinib (Alecensa) ngaphambi kokuqala okuhlosiwe I-Therapy, iziguli zivame ukuhlolwa ngofuzo ukuthola ukuthi zinokuguqulwa kwezakhi ze-mutation.Immunotherapyimmunotherapy zisebenzisa izidakamizwa ukusiza amasosha omzimba alwe nomdlavuza. Le mishanguzo ingavimba amaprotheni avimbela amasosha omzimba ekuhlaseleni amaseli omdlavuza. Izidakamizwa ezijwayelekile ze-NSCLC zifaka: Pembrolikumab (Keytruda) nivolumab (i-Opdivo) i-Atezolumab (i-Opdivo) i-Imvalumab (I-TECENTIQ) I-Imvalumab (IMFINZI) I-Imvalumab (IMFIZI) I-Imvalumap (IMFINZI) I-Imvalumap (IMFINZI) I-Imvalumap (IMFINZI) I-Immunotherap (IMFINZI) Ingasetshenziswa yedwa noma ngokuhlanganiswa ne-chemotherapy noma okunye ukwelashwa. Imiphumela emibi ingafaka ukukhathala, ukuqubuka kwesikhumba, kanye nokuvuvukala kokwelashwa okuhlukahlukene kwe-I-Organs.NSSclc nguStageStage I NSCLCSURGERGENERS I-TRIPASTIONS CHESTION SPEALTION STAGE I NSCLC. I-SBRT ingabhekwa uma isiguli akuyona eyokuhlinzwa.Stage II NSCLCRETETEment yeSiteji II NSCLC imvamisa ifaka ukuhlinzwa okulandelwa yi-chemotherapy. Ukwelashwa kwemisebe kungahle kusetshenziswe.Stage III NSCLCREATION yesiteji III NSCLC iyinkimbinkimbi ngokwengeziwe futhi kungafaka inhlanganisela yokuhlinzwa, i-chemotherapy, nokwelashwa kwemisebe. I-ImmunoSatherapy nayo ingahle isetshenziswe ngemuva kwamakhemikhali kwamakhemikhali.Stage IV NSCLCTETET ye-Stage IV NSCLC igxile ekulambeni ukukhula komdlavuza kanye nokudambisa izimpawu. Izinketho zingafaka i-chemotherapy, ukwelashwa okuhlosiwe, i-immunotherapy, kanye nokwelashwa kwemisebe. Ukukhethwa kokwelashwa kuncike kwizici ezithile zomdlavuza kanye nempilo yesiguli ephelele.clinical izilingo zokuvivinya izivivinyo zokucwaninga izifundo ezihlola ukwelashwa okusha ngomdlavuza. Iziguli ezine-NSCLC zingafanelekela ukubamba iqhaza ezilingweni zokwelashwa. Khuluma nodokotela wakho ukuze ufunde kabanzi mayelana nezilingo zemitholampilo nokuthi zikulungele yini. I-Shandong Baafa Cancer Research Institute Ukuzibophezela ocwaningweni kusho ukuthi sihlala emaphethelweni wokusika izinketho ezintsha zokwelashwa, kwesinye isikhathi ngokulingwa kwemitholampilo. Noma ukwenza izinqumo zokwelashwa zithatha isinqumo esifanele se-NSCLC isinqumo okufanele senziwe ngokubonisana neqembu lakho lezokunakekelwa kwempilo. Izici okufanele zicatshangelwe zifaka isigaba kanye ne-subtype yomdlavuza, impilo yesiguli ephelele, kanye nezinto ezithandayo. Unganqikazi ukubuza imibuzo bese ufuna umbono wesibili uma kudingeka.Prognosis kanye namazinga okusinda okusinda kwe-NSCLC kuyahlukahluka ngokuya ngesigaba somdlavuza, ukwelashwa okutholakele, nezinye izinto. Ukutholwa kusenesikhathi nokwelashwa kungathuthukisa amathuba okusinda. Isigaba seminyaka engu-5 yokusinda kweminyaka engu-68-92% Isigaba II 53-60% Isigaba III 13-36% STAGE IV ngaphansi kuka-10% * Umthombo:www.canser.org) Ukuphila ne-NSclcliving nge-NSCLC kungaba inselele, kepha kunezinsizakusebenza eziningi zokusiza iziguli nemindeni yazo. Lezi zinsiza zifaka amaqembu okusekelana, izinsizakalo zokwelulekwa, kanye nezinhlelo zosizo lwezezimali.