Ukwelashwa komdlavuza wePSMA Prostate

Ukwelashwa komdlavuza wePSMA Prostate Imele intuthuko ebalulekile ekuphatheni umdlavuza we-Prostate, ikakhulukazi umdlavuza we-prostate omelana ne-metastatic castration (MCRPC). Lo mhlahlandlela uhlola okuhlukile Ukwelashwa komdlavuza wePSMA Prostate Izinketho, kufaka phakathi ukwelashwa kwe-radioligand, ukusebenza kwazo, imiphumela emibi, nokuthi zishintsha kanjani isimo sokunakekelwa komdlavuza wendlala yesinye. Funda ngesayensi ngemuva kwe-PSMA, izindlela zokwelapha ezahlukahlukene ezitholakalayo, nokuthi yiziphi iziguli ezingalindela ngesikhathi sokwelashwa i-membrate antigen (PSMA) yiproten echazwe kahle ebusweni be-Protate Cancer cell, Lokhu kwenza i-PSMA ibe yithagethi enhle yokuthola ukucabanga kokuthola nokubhebhethekiswa okubhekiswe kuyo .Ukuphi i-PSMA? Ngenkathi ukuqhamuka kwayo ngokomzimba nzima kusaphenywa, kuyaziwa ukuthi ukuvezwa kwe-PSMA kuphakeme kakhulu kumaseli womdlavuza we-Prostate kuqhathaniswa nezicubu ze-Prostate ezijwayelekile namanye amaseli emzimbeni. Le nkulumo ye-Over-Over-Inkomba ye-Prostate Canceling kanye nokwelashwa kwe-Prostate Cancer and Therapy Lokhu kukhetha kubalulekile ekunciphiseni imiphumela emibi kanye nokwenza ngcono inkomba yokwelapha yokwelashwa komdlavuza wendlala yesinye. Ngaphezu kwalokho, inkulumo ye-psma ivame ukwanda njengoba umdlavuza we-prostate athuthuka, okwenza kube yinhloso ebalulekile ngisho nasezigabeni ezithuthukile zesifo.types of therma-okuhlosiwe kwe-PSMA Ukwelashwa komdlavuza wePSMA Prostate Izindlela zenziwe, zifaka izici eziyingqayizivele ze-PSMA ukuletha ama-ejenti wezokwelapha ngokuqondile kuma-radioligand cell cell.prioling therapy (RLT) I-radioligand therapy (RLT) I-radioligand therapy (RLT) I-radioligand therapy (RLT) I-radioligand therapy (RLT Le radiopharmaceutical bese ifakwa esigulini, lapho ijikeleza khona ngegazi futhi ibopha i-PSMA-ukuveza amaseli womdlavuza we-Prostate. I-Isotope ye-Radioactive ikhipha imisebe elimaza noma ukubulala amaseli omdlavuza. Isibonelo esivelele yi-Lutetium-177 (177LU) PSMA-617.Kusebenza kanjani: I-molecule eqondiwe (e.g., i-PSMA-617) ibopha i-PSMA kumaseli womdlavuza we-Prostate. I-Isotope ye-Radioactive (E.G., Lutetium-177) iletha imisebe kumaseli womdlavuza. Imisebe ilimaza i-Carncers cell cell, okuholela ekufeni kwamaseli.Ukusebenza ngempumelelo: Izilingo zemitholampilo zikhombise ukusebenza ngempumelelo kwe-PSMA-okuqondiswe ku-RLT ekuthuthukiseni ukusinda okuphelele kanye nekhwalithi yempilo ezigulini ezine-MCRPC. Isibonelo, isivivinyo sombono, sikhombise inzuzo enkulu yokusinda nge-177LU-PSMA-617 kanye nezinga lokunakekelwa ngokuqhathaniswa nokunakekelwa kokunakekelwa kuphela. Vakashela I-Shandong Baafa Cancer Research Institute Ukuze ufunde kabanzi ngentuthuko ekwelashweni komdlavuza.Okuqhamuka uma udla imishanguzo: Imiphumela emibi evamile ye-RLT ye-PSMA ifaka ukukhathala, umlomo owomile, isicanucanu, ukucindezelwa kwamathambo (okuholela ekubalweni kwegazi okuphansi), nezinkinga zezinso. Le miphumela emibi ngokuvamile ingalawulwa ngokunakekelwa kwe-eptive.PSMA okubhekiswe kuyo izimbambo zezidakamizwa ze-antibody-dolnjugates aqukethe i-antibodges ehlanganisa i-PSMA, exhunyaniswe nomuthi onamandla we-chemotherapy. Lapho i-antibody ibopha e-PSMA esitokisini somdlavuza, i-ADC iye yangenisa ngaphakathi, futhi umuthi we-chemotherapy ukhishwe ngaphakathi kuseli, wayibulala.Kusebenza kanjani: I-antibody ibopha ePSMA kumaseli womdlavuza we-Prostate. I-ADC ingenziwa ngaphakathi kuseli. Umuthi we-chemotherapy ukhishwa ngaphakathi esitokisini, okuholela ekufeni kweseli.Ukusebenza ngempumelelo: I-AdCS ye-PSMA-okuhlosiwe isakhiwa, kepha izivivinyo zokuqala zemitholampilo zikhombisile imiphumela ethembisayo ezigulini ezine-MCRPC. Ukusebenza kungahluka ngokuya ngezimpawu ezithile ze-ADC neziguli.Okuqhamuka uma udla imishanguzo: Imiphumela emibi incike esingutsheni se-chemotherapy esisetshenziswe kwi-adc futhi ingafaka i-nausea, ukukhathala, ukulahleka kwezinwele, nokucabanga okuhlosiwe kwe-bonerma-okuqondisiwe kuhlanganisa ukusebenzisa amaseli we-PSSACT asebenzisa ngeso lengqondo amaseli we-pet / CT. Lokhu kuvumela odokotela ukuthi bakhombe indawo kanye nezinga lesifo, bahlole ukuphendula ekwelapheni, bese ukhetha iziguli okungenzeka ukuthi zizuze ekwelashweni okuhlosiwe kwePSMA. Le ndlela isibonelo nge-PROROOMESTICS, ihlanganisa nokuxilonga kanye nama-Therapeutics.Kusebenza kanjani: I-tracer ye-radioactive (e.g., Gallium-68 PSMA-11 noma i-fluorine-18 dcfpyl) ifakwe esigulini. I-tracer ibopha ePSMA kumaseli womdlavuza we-Prostate. I-Pet / CT Scan yenziwa ukuze ibone ngeso lengqondo indawo nobukhulu besifo.Ukusebenza ngempumelelo: Ukucabanga okuhlosiwe kwe-PSMA kuzwela kakhulu futhi kuqondile ukuthola umdlavuza wendlala yendlala, kufaka phakathi ama-metastase. Ikwazi ukubona izifo ezingabonakali kuma-modalities ajwayelekile ezimfanekiso. Lolu lwazi lungaqondisa izinqumo zokwelashwa futhi luthuthukise imiphumela yeziguli.Okuqhamuka uma udla imishanguzo: Ukucabanga okuhlosiwe kwe-PSMA kuphephile ngokuvamile, ngemiphumela emincane emibi. Ama-tracer anemisebe asetshenziswe enezimpilo ezimfishane futhi aqedwe ngokushesha emzimbeni. Ngubani umuntu ozongenela ukwelashwa okubhekiswe ePSMA?Ukwelashwa komdlavuza wePSMA Prostate Ngokuvamile kubhekwe iziguli ezinomdlavuza we-prostate we-metastatic castration-engahambisani nokwelashwa okujwayelekile njengokulashwa okuncishisiwe kanye ne-chemotherapy. Abavoti abafanele banenkulumo ephezulu ye-PSMA emathuni abo, njengoba kunqunywe yi-PSMA-PETINGIT.PATION CRIENTION CRITEATION CETYENTION for Ukwelashwa komdlavuza wePSMA Prostate kubalulekile ukukhulisa ukusebenza ngempumelelo futhi kunciphise ubungozi bemiphumela emibi. Izindlela ezibalulekile zifaka phakathi ukuthuthuka kwe-ProstaState Castration Castration (MECRPC) ekwelashweni okujwayelekile (e.g. kusuka ekwelashweni okuhlosiwe kwe-PSMA. Iziguli ezinenkulumo ephezulu ye-PSMA kumathumbu azo maningi amathuba okuthi aphendule ekwelashweni, ngenkathi lezo ezine-Psma ekhuluma zingazuzisako. Ukwelashwa komdlavuza wePSMA Prostate ingahluka ngokuya ngezokwelapha ezithile ezisetshenzisiwe. Kodwa-ke, kunezici ezithile ezijwayelekile zokuqaphela ukuphathwa kwe-.Treement Administration kanye ne-RLTPSMASMA-okuqondiswe kuyo ngokuvamile kulawulwa ngokungenayo ekuhlelweni okungaphandle. Iziguli zingathola imijikelezo eminingi yokwelashwa, ihlukaniswe amasonto ambalwa ihlukane. Ngesikhathi sokwelashwa, iziguli zibhekwe kakhulu ngemiphumela emibi kanye nokuphendula imiphumela emibi yezokwelapha.Imiphumela emibi eshiwo ngaphambili, imiphumela emibi ye-Psma ifaka ukukhathala, umlobi omile, isicanuko somongo wethambo, nezinkinga zezinso. Le miphumela emibi ngokuvamile ingalawulwa ngokunakekelwa okusekelwayo, njengemithi yokudambisa isicanucanu nobuhlungu, ukumpontshelwa igazi ukwelapha i-anemia, kanye ne-hydration ukusekela umsebenzi wezinso. Ukuqapha njalo kwamanani egazi kanye nomsebenzi wezinso kubalulekile ngesikhathi sokwelashwa.Ikusasa le-PSMA-okubhekiswe endlebeni ye Ukwelashwa komdlavuza wePSMA Prostate Uvela ngokushesha, ngocwaningo oluqhubekayo ukuhlola izindlela zokwelapha ezintsha nezithuthukile zokucwaninga kanye nezilingo zemitholampilo ziphenya ama-radioligands amasha aqondiswe ama-radioligands athuthukisiwe kanye namaphrofayili okuphepha. Izindlela zokwelapha ezihlanganisiwe, njengokuhlanganisa i-PSMA-okuhloswe ngazo i-RLT nezinye izindlela zokwelapha ezifana ne-immunotherapy noma i-chemotherapy, nazo ziyahlolwa. I-Shandong Baafa Cancer Research Institute uzibophezele ekuqhubekeni phambili kwalezi zithuthuka ze-PRMA-okuqondiswe ekwakhekeni kwe-PSMA-okuqondiswe e-PSMA kuthuthukisa izindlela zokwelashwa ezihlosiwe ezithuthukisiwe ze-Psma-okuhloswe ngazo ukulungiswa kwezimpawu zeziguli kanye ne-tumor biolookysma Ukwelashwa komdlavuza we-Prostate: IsifinyezoUkwelashwa komdlavuza wePSMA Prostate imele indlela ethembisayo yokuphatha umdlavuza we-prostate othuthukile. Ngokukhetha ngokukhetha i-PSMA-eveza amaseli womdlavuza we-Prostate Prostate, lezi zindlela zokwelapha zingathuthukisa imiphumela kanye nekhwalithi yempilo yeziguli ezine-MCRPC. Njengoba ucwaningo luqhubeka, singalindela ukubona okwengeziwe kulo mkhakha, okuholela ekwelashweni okusebenzayo ngokwengeziwe nokwenziwe ngezifiso komdlavuza we-Prostate. Ukuqhathaniswa kwe-PSMA-okuqondiswe ku-Therapy Izinhlobo zokwelapha zokwelashwa ngendlela esezingeni eliyisibonelo se-Psma-okuqondiswe kuyo i-radioligand therapy (i-ADCS) ihambisa ama-cmusma-617 avunyelwa amaseli we-antibiotheraps aqonde ngqo kumaseli wokuveza ama-psma (ahlukahlukene) Izilingo Zomtholampilo I-Psma-okuqondiswe ku-Imaing Vializes I-PSMA Expression yokuxilongwa kanye nokuhlelwa kokwelashwa Gallium-68, i-fluorine-18 dcfpyl ivunyelwe ukucabanga Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Sicela uthintane nochwepheshe ofanelekayo wezempilo wokuxilongwa kanye nezinketho zokwelashwa.