I-renal cell carcinoma pathology

I-renal cell carcinoma pathology Ibandakanya ukuhlolwa kwemicroscopic nokuhlaziywa kwezicubu zezinso ukuthola nokuhlukanisa umdlavuza wezinso. Kuyisinyathelo esibalulekile ekunqumeni uhlobo, ibanga, kanye nesigaba somdlavuza, okwazisa izinqumo zokwelashwa futhi ubikezela ukufunwa. Ukuqonda izici ze-pathological kubalulekile kuzo zombili iziguli kanye nochwepheshe bezokwelapha. Lo mhlahlandlela uhlinzeka ngesibukezo esinemininingwane ye I-renal cell carcinoma pathology, kufaka phakathi ama-subtypes ajwayelekile, amasistimu wokulinganisa, izitebhisi, kanye neqhaza le-immunocistochemistry.uundong renal cell carcinoma (RCC)I-Renal Cell Carcinoma (RCC) Uhlobo oluvame kakhulu lomdlavuza wezinso kubantu abadala, abalwa cishe ama-90% abo bonke ama-migpancies ezinso. Kuvela kusuka ekulweni kwe-tubule ye-Proximal evumelanisiwe, amashubhu amancane kwizinso ezihlunga igazi futhi zikhiqiza umchamo. Ukuxilongwa okunembile kanye nokuhlukaniswa kwe-RCC kubaluleke kakhulu ekuqondiseni amasu okuhola aphumelelayo kanye nokuqagela ama-renal cell carcinomashereverevereves ahlukahlukene ama-RCC ​​akhona, ngalinye linezici ze-pathological ezihlukile, izici zofuzo kanye nokuziphatha komtholampilo. Lawa ma-subtypes angahlukaniswa ngaphansi kokuhlolwa kwezinto ezicashile futhi aqinisekiswe futhi yi-immunocistochemistry. Ama-subtypes amakhulu afaka phakathi: Sula iseli le-renal cell carcinoma (CCRCC) Sula i-RCC i-RCC etholakala kakhulu, ukubalwa kwemali cishe ngo-70-80% wawo wonke amacala e-RCC. Kuboniswa amaseli ane-cytoplasm ecacile noma ephaphathekile ngenxa yokuqukethwe okuphezulu kwe-glycogen kanye ne-lipid. Lawa maseli ajwayele ukwakha izidleke noma amashidi, futhi isimila ngokuvamile i-vapillarized.papillary renal cell cell cartinoma (PRCC) i-papillary RCC iyi-subtype yesibili evame kakhulu, okwenza ama-10-15% amacala e-RCC. Kubonakala ngokwakha i-papillary, okusho ukuthi amaseli e-tumor akhula ekwakhiweni okufana nomunwe. Kunezinhlobo ezimbili eziphambili ze-PRCC: Uhlobo 1 nohlobo 2 Amaseli e-CHCC ane-Eosinophilic Cytoplasm ephaphathekile ne-halo ehlukile ye-perinuclear. I-nuclei imvamisa yahlanganiswa noma ingekho emthethweni.collecting Duct Renal Cell Carcinoma (CDRCC) Ukuqoqa i-RCC kuyinto engajwayelekile futhi enobudlova obunamandla obuvela ekutholeni izinso. Kubalwa ngaphansi kwamaphesenti ayi-1 amacala e-RCC. Amangqamuzana e-Tumor akha ama-tumor arrebes kanye ne-papillae, imvamisa nge-desmoplary stroma. Lokhu okuhlukile kubonakaliswa yi-carcinoma engahlukaniswanga kahle ngokufakwa okuvelele kokuvuvukala kwe-frading kwe-renal cell carcinoma: Uhlelo lwe-FUHRMAN Systering kanye nohlelo lwe-Isup systession lwe-RCC lubonisa ubutha besimila ngokususelwa kumaseli ngaphansi kwesibonakli esincane. Uhlelo lweFuhrman Grading ngokwesiko lwalusetshenziswa ngokwesiko, kepha umphakathi wamazwe omhlaba we-Urogical Pathology (ISUp) uhlelo lwe-Grading manje selutholwe kakhulu. Uhlelo lwe-Isup Grading lubheka ukuvelela kwe-nucleolar kanye nokungahambi kahle kwenuzi. Amabanga aphezulu akhombisa ama-tumors anolaka kakhulu futhi ahlotshaniswa ne-prognosis ehlwempu. I-Isup Grade Consuregram grade 1 encane, i-nuclei eyunifomu ene-nucleoli engekho emthethweni noma engekho. Ibanga 2 likhudlwana kancane kancane nge-nucleoli ebonakalayo. Ibanga 3 elikhulu, i-nuclei engajwayelekile ene-nucleoli evelele. Ibanga 4 ngokungajwayelekile, i-pleomorphic nuclei enobukhulu obumangazayo noma umehluko we-sarcomatoid. Izitebhisi ze-Renal Cell Carcinoma: I-TNM SystemStaging ye-RCC ichaza ubukhulu bomdlavuza, kufaka phakathi usayizi wesimila esiyinhloko (t), ukubandakanyeka kwama-lymph node (n), kanye nokuba khona kwe-metastasis (n). Uhlelo lwe-TNM Stiaging luhlelo olusetshenziswa kakhulu lwe-RCC. Ukuzibandakanya okunembile kubalulekile ekunqumeni izinketho zokuthola amandla kanye nokwelashwa.Indlela ethile yezigaba ze-T, n, kanye ne-M, ubungako bezindawo, nokuba khona kwezikhukhula, kanye nokuba khona kwezitho ze-lymph noma izitho ezikude. Izazi ze-Pathologists zisebenzisa okutholakele ama-microscopic kanye nemiphumela yokucabanga ukunikeza i-TNM Stage.Immunohistochemistry eRenal Cell Carcinoma PazoloofiirmunoHistonoHistonoHistochemistry (IHC) iyithuluzi elibalulekile ngaphakathi I-renal cell carcinoma pathology. Kubandakanya ukusebenzisa ama-antibodies ukuthola amaprotheni athile kumasampula wezicubu. Le mbuzo yenqubo yokuhlukanisa phakathi kwama-RCC ​​ama-subtypes, eqinisekisa ukuxilongwa, nokuhlonza okuhlosiwe okungaba khona kokwelapha. Izimpawu ezijwayelekile ze-IHC ezisetshenzisiwe ku-RCC zifaka: I-PAX8: Umaki ovame ukuvezwa kuma-renal cell carcinomas, ikakhulukazi iseli eliphansi kanye ne-papillary subtypes. I-Caix: Kuvezwa kaningi kuma-carcinomas acacile we-cell cell. I-CK7: Iwusizo ekuhlukaniseni phakathi kwama-subtypes ahlukene we-RCC, evame ukuba nomuhle ePapillary ne-Chromophobe RCC. IVerinenIn: Imvamisa kune-Sarcomatoid RCC. I-CD117 (C-KIT): ingasiza ekuhlolweni kombiko we-Chromophobe RCC.Renology: Izinto ezibalulekile I-Pathology Reports idokhumenti elibalulekile elifingqa okutholakele kokuhlolwa kwe-pathological. Kubandakanya izinto ezibalulekile ezilandelayo: imininingwane yesineke nemininingwane ekhethekile. Incazelo ephelele yesimila. Ukuchazwa kwemicroscopic kwamaseli we-tumor kanye nezakhiwo. Ukuxilongwa kwe-RCC subtype. Ibanga le-Isup. Isigaba se-TNM. Imiphumela ye-immunohistochemical. Isimo seMargins (noma ngabe amaseli omdlavuza akhona emaphethelweni ezicubu ezisusiwe). Amazwana we-PathOlogist kanye nesifingqo.Imbani yeShandong Bandong Baafa Cancer Research Institunations okufana I-Shandong Baafa Cancer Research Institute dlala indima ebalulekile ekuthuthukiseni ukuqonda kwethu nokwelashwa kwethu kwamakhashane, kufaka phakathi renal cell carcinoma. Ngokwenza ucwaningo kanye novivinyo lwezempilo, lezi zikhungo zifaka isandla ekuthuthukisweni kwamathuluzi amasha okuxilonga kanye nokwelashwa, ekugcineni kuthuthukisa imiphumela yeziguli.ConclusionI-renal cell carcinoma pathology yinkambu eyinkimbinkimbi ehilela ukuhlolwa ngokucophelela nokuhlaziywa kwezicubu zezinso. Ukuqonda ama-subtypes ahlukile, amasistimu wokulinganisa, izitebhisi, kanye neqhaza le-immunohistochemistry kubalulekile ekutholeni ukuxilongwa okunembile, ukufunwa kwe-prognosis, kanye nokwelashwa. Ukusebenzisana phakathi kwezazi ze-pathologists, ama-oncologists, kanye nabanye ochwepheshe bezokunakekelwa kwempilo kubalulekile ekuhlinzekeni ukunakekelwa okungcono kakhulu kweziguli ezine-RCC.Ukuzikhulula: Lolu lwazi ngolwazi olujwayelekile kanye nezinhloso zolwazi kuphela, futhi alwenzi izeluleko zezokwelapha. Kubalulekile ukuthintana nochwepheshe wezempilo ofanelekayo nganoma yiziphi izinkathazo zezempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo yakho noma yokwelashwa.Izinkomba: I-American Cancer Society Isisekelo Sezinso Zozwe