I-Sustaged Reser Delivery Regived Therapy: Ukubuka okuphelele okuphelele

Ukwelashwa kwezidakamizwa okulondoloziwe kunikeza indlela yezinguquko ekuphathweni kwemithi, ukuhlinzeka ngamazinga wezidakamizwa angaguquguquki esikhathini esengeziwe. Lo mbhalo uhlola izindlela, izinzuzo, izinhlelo zokusebenza, kanye nezinkomba zesikhathi esizayo ze Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo, ukubhekana nokucatshangelwa okubalulekile kweziguli kanye nabaqeqeshiwe bezempilo.

Izindlela zokulethwa kwezidakamizwa okulondoloziwe kwezidakamizwa

Izinhlelo zokukhishwa ezilawulwayo

Izinhlelo ezahlukahlukene zisiza Ukulethwa kwezidakamizwa okulondoloziwe. Ngokwesibonelo, ngokwesibonelo, faka umuthi ngaphakathi kwe-matrix ye-polymeric ekhuphuka kancane kancane noma ukudicilela phansi, kukhipha umuthi ngesilinganiso esilawulwayo. Ngakolunye uhlangothi ama-reservoir systems, ngakolunye uhlangothi, uvumela umuthi ngaphakathi kolwelwesi, ukuvumela ukukhishwa okulawulwa ngokungemthetho. Lezi zinhlelo zinikezela ngezinzuzo ezihlukile ngokuya ngezidakamizwa kanye namaphrofayili wokukhipha afisa. Ukukhethwa kohlelo kuthinta kakhulu isikhathi nokuvumelana kokulethwa kwezidakamizwa. Ukuqonda lezi zinqubo kubalulekile ukuthola ukwelashwa okuhambisana nezidingo zeziguli ngazinye.

Izici ezithinta ama-Kinetics okukhululwa

Kunezici eziningana zithonya ama-Kinetics ezidakamizwa kusuka Izinhlelo zokulethwa kwezidakamizwa ezilondoloziwe. Lokhu kufaka phakathi izakhiwo ze-dlicochemical (i-solubity, i-permeability), izici ze-polymer (izinga lokuwohloka, izimpaphe), nokwakheka kohlelo (usayizi, ukwakheka kwejometri). Ukulawulwa okuqondile ngalezi zinto kubalulekile ukuze uzuze umphumela owuthandayo wezokwelapha ngenkathi unciphisa imiphumela emibi. Amasu wokumodeli athuthukile aya ngokuya esetshenziselwa ukubikezela nokwandisa amaphrofayili okukhishwa kwezidakamizwa.

Izinzuzo zokulethwa kwezidakamizwa okulethwa kwezidakamizwa

Ukutholwa okuthuthukile kweziguli

Inzuzo eyodwa enkulu ye Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo ukutholwa kweziguli okuthuthukisiwe. Imvamisa encishisiwe ye-dosing kusho ukuthi iziguli mancane amathuba okuthi ziphuthe imithamo, okuholela emiphumeleni engcono yokwelapha. Lokhu kuzuzisa ikakhulukazi izimo ezingamahlalakhona ezidinga umuthi wesikhathi eside. Ukusebenziseka kalula kwe-dosing evamile ekhulisa kakhulu ukunamathela kuRegimens yokwelashwa.

Imiphumela emibi encishisiwe

Ngokugcina amazinga wezidakamizwa angaguquki, Ukulethwa kwezidakamizwa okulondoloziwe kunganciphisa ukugxila kwe-peak plasma, ngaleyo ndlela kunciphise izehlakalo nobunzima bemiphumela emibi. Lokhu kubaluleke kakhulu kwizidakamizwa ezinama-indices aphansi wezokwelapha, lapho ukuguquguquka kwamazinga we-plasma kungalimaza. Iphrofayili yokukhishwa elawulwayo ivumela ukulethwa kwezidakamizwa okuhlosiwe, ukunciphisa ukuvezwa okuhleliwe nemiphumela emibi ehlobene.

Impumelelo yezokwelapha ethuthukisiwe

Ukugcina ukugxila kwezidakamizwa okungokwelashwa ngaphakathi kwebanga elifanele lezikhathi ezeluliwe zingathuthukisa kakhulu ukusebenza kwezokwelapha. Lokhu kungaholela ekuphathweni okuthuthukile kwezifo kanye nemiphumela yeziguli engcono. Isibonelo, ekwelashweni komdlavuza, Ukulethwa kwezidakamizwa okulondoloziwe kungathuthukisa ukusebenza kwe-chemotherapy ngokunikeza ukuvezwa okuqhubekayo kumaseli womdlavuza.

Izicelo zokwelashwa kwezidakamizwa zokulethwa kwezidakamizwa

Ukwelashwa komdlavuza

Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo ukhombise isithembiso esibalulekile ekwelashweni komdlavuza. Ivumela ukulethwa okuhlosiwe kwama-chemotherapeic agents ngqo kwisiza se-tumor, ukunciphisa ubuthi obuhlelekile. Le ndlela iguqule amasu okulashwa kumdlavuza othize, ukuthuthukisa amanani okusinda kanye nekhwalithi yempilo.

Ukuphathwa kwesifo sikashukela

Ekuphathweni kwesifo sikashukela, Izinhlelo zokulethwa kwezidingo ze-insulin uguqule izindlela zokwelashwa, ukuhlinzeka ngamaphethini wokukhishwa kwe-insuliolical insulical kanye nokwenza ngcono ukulawulwa kwe-glycemic. Lezi zinhlelo zinikeza ukuthuthuka okukhulu ekuphatheni amazinga kashukela wegazi ngokuqhathaniswa nemijovo yendabuko ye-insulin.

Ukuphathwa kobuhlungu

Kwezimo zobuhlungu ezingapheli, Ukulethwa kwezidakamizwa okulondoloziwe Inikeza impumuzo ebuhlungu esebenzayo ngemiphumela emibi embalwa uma iqhathaniswa nezimo ezijwayelekile zokukhishwa ngokushesha. Lokhu kunikeza iziguli ezinenduduzo eyengeziwe nekhwalithi yempilo ethuthukisiwe.

Izikhombisi zekusasa zokwelashwa kwezidakamizwa zokukhishwa kwezidakamizwa

Insimu ye Ukulethwa kwezidakamizwa okulondoloziwe kuyavela ngokuqhubekayo. Intuthuko nge-nanotechnology, i-biomodium, kanye nezinhlelo zokulethwa kwezidakamizwa zithembisa ukuthuthukisa ukusebenza kwezidakamizwa nokuphepha. Izindlela zomuntu ezenziwe umuthi futhi ziyahlolwa, ukuhambisana nezinhlelo zokulethwa kwezidakamizwa ezidinga izidingo zeziguli ngazinye ezisuselwa ezicini zofuzo neze-metabolic. Ukuhlanganiswa kobuchwepheshe obuhlakaniphile, njengezinzwa kanye nabenzi bokusebenza, izithembiso zokwenza ngcono ukukhishwa kwezidakamizwa nokubheka impendulo yokwelapha ngesikhathi sangempela.

Ukugcina

Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo imelela intuthuko ebalulekile kwisayensi yezemithi. Izinzuzo zayo, kufaka phakathi ukuhambisana okuthuthukile kweziguli, okuncishisiwe kwemiphumela emibi, kanye nokusebenza kahle kokwelapha okuthuthukisiwe, kwenze kube yindlela ebalulekile yokwelapha izifo ezahlukahlukene. Imizamo eqhubekayo yokucwaninga nemizamo yentuthuko iyaqhubeka ukwandisa izinhlelo zayo futhi ithuthukise ukusebenza kwayo.

Ngeminye imininingwane ngocwaningo lomdlavuza nokwelashwa, sicela uvakashele I-Shandong Baafa Cancer Research Institute.