Ukwelashwa kokulethwa kwezidakamizwa kwezidakamizwa ezibhedlela ezibhedlela

Le ndatshana ihlinzeka ngesibukezo esibanzi sokulethwa kwezidakamizwa okulondoloziwe kwezidakamizwa (SRDD) kanye nezinhlelo zayo ezisetshenziselwa ezibhedlela. Sizohlola izinhlobo ezahlukahlukene zezinhlelo ze-SRDD, izinzuzo zazo kanye nobubi, neqhaza elibalulekile abalidlalayo ekuthuthukiseni imiphumela yeziguli. Sizohlola nokucatshangelwa kokudla okuvela ezibhedlela ezisebenzisa izindlela zokwelapha ze-SRDD.

Yini ukwelashwa okulethwa kwezidakamizwa okuqhubekayo?

Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo, owaziwa nangokuthi ukukhishwa okulawulwayo noma ukwelashwa okudedelwe, kubandakanya ukuphathwa kwemithi ngendlela ekhipha kancane isidakamizwa isikhathi eside. Lokhu kuqhathaniswa nezindlela zokukhishwa ngokushesha, lapho kukhishwa khona umuthi ngokushesha. I-SRDD ihlose ukugcina ukugxila kwezidakamizwa kwezidakamizwa zezokwelapha isikhathi eside, kunciphisa imvamisa yokuphatha kanye nokwenza ngcono ukulandelwa kweziguli. Le ndlela inenzuzo ikakhulukazi yezidakamizwa ezinezimpilo ezimfishane noma ezidinga i-dosing ejwayelekile. Izinzuzo zinwebeka ukuze zithuthukise induduzo yeziguli futhi zinciphise imiphumela emibi ehambisana namazinga ezidakamizwa aguquguqukayo.

Izinhlobo zezinhlelo zokukhishwa kwezidakamizwa ezilondoloziwe

Izinhlelo eziningi ze-SRDD zikhona, ngalinye linezimpawu ezihlukile:

Amaphampu angenakufinyeleleka

Amaphampu angenakufinyeleleka anikeza ukukhishwa okuqhubekayo nokulawulwa kwemithi. Lokhu kuvame ukusetshenziselwa ukunikeza izidakamizwa ezidinga ukunqunyelwa okuqondile kwezikhathi ezengeziwe, njengokuphathwa kwezinhlungu noma ukuphathwa kwe-chemotherapy.

Amakatiri

Izinhlelo ze-matrix zifaka umuthi ngaphakathi kwe-matrix ye-polymer ekhipha kancane isidakamizwa ngokuhamba kwesikhathi. Izinga lokukhishwa lincike ezintweni ezifana nezakhiwo ze-polymer kanye ne-solubening yesidakamizwa.

Izinhlelo ze-Reservoir

Izinhlelo ze-Reservoir zihlanganisa umuthi esitsheni esitsheni, ngolwelwesi olungavunyelwe khona olulawulwa inani lokukhishwa. Lezi zinhlelo zinganikeza iphrofayili yokukhishwa engaguquki kunezinhlelo ze-matrix.

Ama-liposomes nama-nanoparticles

I-Liposomes nama-nanoparticles ama-vesicles amancane noma izinhlayiya ezihlanganisa umuthi. Banikela ngokulethwa okuqondisiwe, okwandisa ukugxilwa kwezidakamizwa esizeni sesenzo nokunciphisa imiphumela emibi.

Izinzuzo ze-SRDD ezibhedlela

Ukuqaliswa kwe Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo Ezibhedlela zinikeza izinzuzo eziningi ezibalulekile:

• Ukuthobela okuthuthukisiwe kwesiguli ngokunciphisa imvamisa ye-dosing
• Ukusebenza kahle kwezokwelapha okuthuthukisiwe ngokugcina amazinga wezidakamizwa angaguquki
• Imiphumela emibi encishisiwe ehlotshaniswa nokuguquguquka kwezidakamizwa okuguquguqukayo
• Ikhwalithi ethuthukisiwe yempilo yeziguli, ikakhulukazi lezo ezinezimo ezingamahlalakhona
• Amathuba okulondolozwa kwezindleko ngenxa yokuncishiswa kwesibhedlela nokuphathwa kwemithi

IZINSELELE NOKUFUNDA KWAMAHHALA

Naphezu kwezinzuzo, ukusebenzisa i-SRDD ezibhedlela kuveza izinselelo:

• Izindleko eziphakeme zokuqala zezinhlelo ze-SRDD ziqhathaniswa nokwakhiwa okujwayelekile
• Isidingo sokuqeqeshwa okukhethekile kochwepheshe bezokunakekelwa kwempilo ekuphatheni nasekuphatheni izinhlelo ze-SRDD
• Amathuba okuba nezinkinga, njengokungasebenzi kahle kwemishini noma ukutheleleka ngezinhlelo ezibonakalayo
• Ukuqapha ngokucophelela iziguli ezithola ukwelashwa kwe-SRDD kubalulekile ukuze kuqinisekiswe ukusebenza kahle futhi kubona izinkinga ezingaba khona

Iqhaza leShandong Baofa Cancer Research Institute e-SRDD

Izikhungo ezifana ne I-Shandong Baafa Cancer Research Institute dlala indima ebalulekile ekuthuthukiseni ucwaningo, ukuthuthukiswa, kanye nokwenziwa kwezokwelapha ezintsha Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo. Ukuzinikela kwabo ekuhlinzekeni umdlavuza wokusika umdlavuza wokusika kufaka phakathi ukuhlola nokwamukela izindlela zokwelashwa ezisebenza kahle kakhulu ezitholakalayo. Izindlela zokwelapha ezithuthukile, njenge-SRDD, ziyingxenye ebalulekile yokuzibophezela kwabo ekuhlinzekeni ukunakekelwa kweziguli ezisezingeni eliphakeme.

Izinkomba zesikhathi esizayo ze-SRDD

Ucwaningo luyaqhubeka nokwenza ngcono izinhlelo ze-SRDD, zigxile ku:

• Ukuhlakulela Okuhambisanayo Okuhambisanayo Kokufana Kokufana Kwe-BioComp3
• Ukwenza ngcono izindlela zokuqondisa ukulethwa kwezidakamizwa okuthuthukisiwe
• Ukuthuthukisa izinhlelo ezihlakaniphile eziphendula izinguquko zomzimba

Ikusasa le Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo Uphethe isithembiso esikhulu sokwenza ngcono ukunakekelwa kweziguli ezibhedlela emhlabeni jikelele.

Ukunqubekela phambili

Ngenkathi izifundo ezithile zibhekisa i-SRDD ezibhedlela ziningi futhi zisakazeka kuwo wonke amaphephabhuku ahlukahlukene, ukubuka konke okujwayelekile kobuchwepheshe obuxhaselelwayo kungatholakala emibhalweni eminingi yemithi nemininingwane yolwazi efana nePubMed. Ukuze uthole izifundo ezithile zamacala noma ucwaningo olwenziwe nguShandong Baafa Cancer Research Institute, sicela ubheke kuwebhusayithi yabo esemthethweni.