Ukwelashwa Okukhulu Kwe-Cell Lunging Ranc ratical Ukwelashwa

I-Cell Cell Lung Cancer (LCLC) iyisigatshana esinamandla somdlavuza we-cell ongewona omncane (NSCLC). Izindlela zokwelashwa zivame ukubandakanya inhlanganisela yokuhlinzwa, i-chemotherapy, ukwelashwa kwemisebe, ukwelashwa okuhlosiwe, kanye ne-immunotherapy, ehambisana nesigaba sesiguli, impilo ephelele nezici ze-tumor. Intuthuko yakamuva yemithi ye-molecular kanye nezokwelapha ezenziwe ngezifiso zithuthukisa imiphumela yalabo abatholakele i-LCLC.Ukuqonda okukhulu komdlavuza wamaphaphu umdlavuza omkhulu weseli?Ukwelashwa okukhulu komdlavuza wamaphaphu (LCLC) uhlobo lomdlavuza wamaphaphu ongewona omncane. Kuthola igama laso emangqamuzane amakhulu, abukeka ngokungafanele abonile ngaphansi kwesibonakhulu. I-LCLC ivame ukukhula futhi isakazeka ngokushesha, yenza ukuxilongwa kusenesikhathi nokwelashwa kubalulekile. Ngenkathi kuvame ukwedlula ezinye izinhlobo ze-NSCLC, ukuqonda izici zayo kubalulekile ekuphathweni okusebenzayo. Ezinye izici zobungozi zifaka ukuvezwa kwentuthu ye-Secondhand, iRadon, asbestos, kanye nezinto ezithile zezimboni. Ukuyeka ukubhema, ukugwema ukuvezwa kuma-carcinogens owaziwayo, futhi ukulondolozela indlela yokuphila enempilo yizindlela ezinhle kakhulu zokuvimbela. Ukuhlolwa okujwayelekile kokuhlola nokuhlolwa komdlavuza wamaphaphu wengozi ephezulu kungasiza ekutholweni kusenesikhathi futhi kube ngcono ukuthuthuka ukwelashwa okukhulu komdlavuza wamaphaphu Izinketho ze-Outsomis.Streaty ze-Cell Cell Lung ConsarsurseryGery imvamisa zingumugqa wokuqala wokwelashwa we-LCLC yesigaba sokuqala, lapho isimilo sendawo sisendaweni futhi asikaze sisakaze kumasayithi akude. Inqubo yokuhlinza ingabandakanya ukususa ingxenye yokulungile kwamaphaphu (we-wedge noma i-segmetectomy), lonke lobe (loberctomy), noma ngisho lonke amaphaphu (pneumonectomy). Ukukhethwa kokuhlinzwa kuncike ngosayizi nendawo yendawo yesimila, kanye nomsebenzi wamaphaphu ophelele wamaphaphu. Amaqembu okuhlinza ama-Shandong Baafa Cancer Research Institute anolwazi kakhulu kulezi zinqubo.Chemotherapychemothemothery ukwelashwa okuhleliwe okusebenzisa izidakamizwa ukubulala umdlavuza emzimbeni wonke. Imvamisa isetshenziswa ngokuhlanganiswa nokuhlinzwa noma ukwelashwa kwemisebe, noma ukwelashwa okuyinhloko kwe-LCLC esezingeni eliphakeme. Ama-regimens ajwayelekile we-chemotherapy we-LCLC afaka izidakamizwa ezisuselwa kwiplatinamu (njenge-cisplatin noma i-carboplatin) ehlanganiswe namanye ama-chemotherapy agents. Imiphumela emibi ye-chemotherapy ingafaka i-nausea, ukukhathala, ukulahleka kwezinwele, kanye nengozi eyandayo yokutheleleka.Radiation therapyradiation therapy isebenzisa imisebe yomdlavuza ukuqondisa nokubhubhisa amaseli womdlavuza. Ingasetshenziswa ukwelapha i-LCLC ngezindlela eziningi: njengokwelashwa okuyinhloko kweziguli okungezona ama-ukhetho ngokuhlinzwa ngemuva kokuhlinzwa ngemuva kokubulala noma yimaphi amangqamuzana omdlavuza, noma ukuncipha kokuphefumula esifweni esisezingeni eliphakeme. Izinhlobo zokwelashwa kwemisebe ezisetshenziselwa i-LCLC zifaka ukwelashwa kwemisebe yangaphandle ye-beam (EBRT) kanye nokwelashwa kwemisebe yemisebe ye-stereotactic (SBT). Lezi zindlela zokwelapha zisebenza ngokukhethekile ezigulini ezinokuguqulwa okuthile kofuzo emigwaqweni yazo. Amatshe ajwayelekile ku-LCLC afaka i-EGFR, Alk, Ros1, ne-BRAF. Ngaphambi kokuqala ukwelashwa okuhlosiwe, iziguli zivame ukuhlolwa kwama-molecular ukunquma ukuthi izingelu zazo zinalezi zinguquko ezisebenzayo yini. Uma udinga usizo oluthile, Isikhungo Sokucwaninga Nge-Baofa Cancer cwaninga singanikela ngezinsizakalo zokuhlola izakhi zofuzo.Immunotherapyimmunotherapy harnesses amandla we-immuncy system uqobo ukuze alwe nomdlavuza womzimba ukuze alwe nomdlavuza. I-Imgve Phezulu I-inhibitors, njenge-pembrolikumab, nivolumab, ne-atezolikumab, uhlobo lwe-immunotherapy oluvimba amaprotheni avimbela amasosha omzimba ekuhlaseleni amaseli omdlavuza. I-ImmunoSatheraPy ikhombisile imiphumela ethembisayo ekwelapheni i-LCLC, ikakhulukazi ezigulini eziwumshuka ovelele amazinga aphezulu we-PD-L1. It can be used as a first-line treatment for advanced-stage LCLC or after chemotherapy has failed.Advances in Large Cell Lung Cancer TreatmentMolecular ProfilingMolecular profiling involves analyzing a patient's tumor tissue to identify specific genetic mutations or other molecular alterations that may be driving the cancer's growth. Lolu lwazi lungasiza odokotela ukuthi bakhethe ukwelashwa okufanelekile kakhulu noma i-immunotherapy yesiguli ngasinye. Ukulandelwa kwesizukulwane esilandelayo (ama-NGS) kuyindlela ejwayelekile esetshenziselwa ukufaka amaphrofayili ama-molecular, ukuvumela ukutholwa kanyekanye kwezakhi zofuzo eziningi.Imininingwane yemithi yemithi yemithi ukwelashwa okukhulu komdlavuza wamaphaphu esigulini ngasinye esisuselwa kuphrofayela ye-molefanelar yaso, impilo ephelele, kanye nezintandokazi. Le ndlela ihlose ukukhulisa ukusebenza kahle kokwelashwa ngenkathi kunciphisa imiphumela emibi. Umuthi owenziwe ngezifiso ubaluleke kakhulu ekuphathweni kwe-LCLC, ngoba uvumela odokotela ukuthi bakhethe isu elifanele kakhulu lokwelashwa kwezilingo zokufunda iziguli ezifundwayo ezihlola ukwelashwa okusha noma ukuhlanganiswa kokwelashwa kwe-LCLC. Ukubamba iqhaza kwecala lomtholampilo kunganikeza iziguli ukufinyelela ezokwelapha ezisikayo ezingatholakali kabanzi. Ukuvivinywa kwemitholampilo kuyingxenye ebalulekile yokuqhubekisela phambili ukunakekelwa komdlavuza, futhi iziguli kufanele zixoxe nodokotela baso noma ngabe zibambe iqhaza ekuhlolweni komtholampilo ziyindlela enhle ye-LCLC ziyahlukahlukana, kanye nempilo yesiguli, kanye nempendulo yokwelashwa jikelele. I-LCLC yesigaba sokuqala esiphathwe ngokuhlinzwa inesifo esingcono kune-LCLC esezingeni eliphakeme elisakazekele ezingosini ezikude. Intuthuko ekwelashweni, njengokwelashwa okuhlosiwe kanye ne-immunotherapy, bathuthukile amanani okusinda ezigulini nge-LCLC eminyakeni yamuva. Amanani weminyaka emi-5 yokusinda kwe-cell annowles, NSCLC) ngesilinganiso se-STAGE1 STAGE ASTIVAL Rate asendaweni engu-63% yesifunda esingu-63% Yonke indawo yokubhekisisa engu-26% Yonke indawo yokubuka umdlavuzo nge-LCLC ingaba inselelo yokusiza iziguli nemindeni yabo ibhekana nemiphumela yangempela nangokomzwelo yalesi sifo. Amaqembu okusekela, ukwelulekwa, kanye nokunakekelwa kwe-palliative kunganikeza usizo olubalulekile. Ukugcina impilo enempilo, kufaka phakathi ukudla okulinganiselayo nokuzivocavoca njalo, kungathuthukisa nekhwalithi yempilo. Ukuxoxa ukukhathazeka nemibuzo nethimba lakho lezempilo kubalulekile ekuphatheni i-LCLC ngempumelelo ye-LCLC.FisesNerous Izinhlangano zinikeza ukwesekwa kanye nezinsizakusebenza zabantu abatholakala nge-LCLC nemindeni yabo. Lezi zinsiza zifaka izinto zokufundisa, amaqembu okusekela, izinhlelo zosizo lwezezimali, kanye nemizamo yokumela. Ukuxhuma ngalezi zinsizakusebenza kunganikeza ukusekelwa okubalulekile nokuholwa kulo lonke uhambo lomdlavuza.Izinkomba: I-American Society of Clinical Oncology (ASCO): Umdlavuza wamaphaphu - iseli elingelona elincane: Izibalo.