Ukwelashwa kokulethwa kwezidakamizwa kwasendaweni komdlavuza

Le ndatshana ihlinzeka ngesibukezo esiphelele sezinhlelo zasendaweni zokulethwa kwezidakamizwa zokwelashwa komdlavuza, ukuhlola izindlela ezahlukahlukene, izinzuzo, ukulinganiselwa, kanye nezinkomba zesikhathi esizayo. Sisebenzisa izindlela, izinhlelo zemitholampilo, kanye nemizamo yokucwaninga eqhubekayo kule nkambu yokuvela ngokushesha. Funda ngentuthuko yakamuva kwezingoma ezihlosiwe ezihlose ukukhulisa ukusebenza kahle ngenkathi unciphisa imiphumela emibi ehleliwe.

Ukuqonda Ukulethwa Kwezidakamizwa Esendaweni

Kuyini ukulethwa kwezidakamizwa kwasendaweni?

Ukulethwa kwezidakamizwa okwenziwe endaweni Ngoba umdlavuza ubhekisa ezindleleni eziletha abenzeli bezokwelapha ngqo kwisiza se-tumor, benciphisa ukuvezwa kwezicubu ezinempilo. Le ndlela ebhekiswe kuyo ihlose ukuthuthukisa ukusebenza ngempumelelo, futhi ithuthukise ubuthi, futhi ithuthukise imiphumela yeziguli uma kuqhathaniswa nezindlela zokwelapha ezihlelekile zendabuko. Kuqashwa amasu ambalwa, ngalinye linezinzuzo zalo kanye nemikhawulo.

Izindlela zokulethwa kwezidakamizwa ezenziwe zasendaweni

Izindlela eziningana zisiza Ukulethwa kwezidakamizwa okwenziwe endaweni, kufaka phakathi: Ukufakwa kwamadivayisi athatha izidakamizwa (isb. Lezi zindlela zixhaphaza izici eziyingqayizivele ze-tumor microenvelorment ukuze zithuthukise ukugxilwa kwezidakamizwa endaweni okuhlosiwe.

Izinhlobo zezinhlelo ezenzelwe ukulethwa kwezidakamizwa zasendaweni

Amadivayisi angenakufinyeleleka

Amadivaysi angenakufinyeleleka, afana nama-polymers we-bioderlines kanye nama-microsmares, anikele ukukhishwa okuqhubekayo kwama-chemotherapeic agents ngokuhamba kwesikhathi. Le ndlela inciphisa imvamisa yokuphatha futhi kungenzeka ukuthi ithuthukise ukuthobela iziguli. Kodwa-ke, isilinganiso sokukhululwa nobude besikhathi badinga ukusebenza ngokucophelela ukufeza umphumela owuthandayo wezokwelapha. I-Shandong Bandong Bacco Cancer Research Institute isephambili ocwaningweni kulezi zindawo.

Imijovo

Umjovo oqondile wezidakamizwa esigxotsheni sesimila kungenye indlela evamile. Le ndlela ihlinzeka ngokugxila kwezidakamizwa okuphezulu kwezidakamizwa kodwa ingahle ingasebenzi kuzo zonke izinhlobo zama-tumor noma izindawo. Le ndlela ivame ukusetshenziswa ngokubambisana nezinye izindlela zokucabanga zokuqondisa okuqondile.

Ukulethwa Okusekelwe KwamaNanoparticle

I-nanoparticle-based Ukulethwa kwezidakamizwa okwenziwe endaweni Amasistimu athola amandla okuvuselelwa okuthuthukile kanye nokugcinwa (EPR) umphumela we-tumor vasculature. Lezi zinhlaka zakwama-nanoparticles ziphatha umuthi ku-turos, ziqongelelwa ngokukhethekile ngenxa yemithambo yegazi evuzayo. Kodwa-ke, ukuzuza ukuqondiswa kwesimila okusebenzayo nokulawula ukukhishwa kwe-nanoparticle kuhlale kuyizinselelo ezibalulekile. Ukuthuthukiswa kwama-nanoparticles anoveli anezakhiwo eziqondisiwe eziqondisiwe kuyindawo esebenzayo yocwaningo.

Izicelo zemitholampilo kanye nocwaningo oluqhubekayo

Izicelo zamanje zemitholampilo

Ukulethwa kwezidakamizwa okwenziwe endaweni Amasistimu njengamanje asetshenziswa ekwelashweni okuhlukahlukene komdlavuza, kufaka phakathi: ama-tulam abuchopho (asebenzisa ama-wafers afakiwe), umdlavuza we-prostate (usebenzisa i-brachytherapy), kanye nezinhlobo ezithile zomdlavuza webele. Indlela ethile ekhethiwe incike ngohlobo nesigaba somdlavuza.

Ithebula 1: Ukuqhathanisa okuhlukile Ukulethwa kwezidakamizwa okwenziwe endaweni Izindlela.

Izikhombisi Zekusasa

Ucwaningo lwesikhathi esizayo ku Ukulethwa kwezidakamizwa okwenziwe endaweni Sizogxila ekuthuthukiseni ukucaciswa kokuqondisa, ukulungiselela ama-kinetics okukhishwa kwezidakamizwa, kanye nokuthuthukisa izimoto zonoveli zokulethwa kwezidakamizwa. Ukuhlanganisa Ukulethwa kwezidakamizwa okwenziwe endaweni Ngazo ezinye izindlela zokwelapha, njengokuthi i-Im-immunotherapy, ingahle ithuthukise imiphumela yokwelashwa. Amandla okwenzelwe umuntu uqobo Ukulethwa kwezidakamizwa okwenziwe endaweni, ehambisana nezimpawu zesiguli ngazinye, nayo iyindawo ebalulekile yentshisekelo.

Ngeminye imininingwane ngocwaningo lomdlavuza kanye nezinketho zokwelashwa, sicela uvakashele I-Shandong Baafa Cancer Research Institute Iwebhusayithi.