Ukwelashwa Metastatic Okungaphansi Kwe-Cell Lunging Roudlarth Terract

Ukwelashwa kwe-metastatic okungeyona incane ye-cancerthis Article kuhlinzeka ngesibukezo esiphelele sezinketho zokwelashwa ze-metstatic umdlavuza we-metastatic ongewona amaphaphu (NSCLC), kufaka phakathi i-chemotherapy, ukwelashwa okuhlosiwe, kanye nokwelashwa kwemisebe. Sihlola intuthuko yakamuva kanye nokucatshangelwa kokukhetha uhlelo lokwelashwa olusebenzayo olususelwa ezintweni ezithile zeziguli. Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uthole ukuholwa komuntu uqobo.

Ukuqonda umdlavuza we-metastatic ongewona omncane

Umdlavuza we-metastatic ongewona omncane weseli (NSCLC) Kwenzeka lapho amaseli womdlavuza avela emaphashini asakazeka kwezinye izingxenye zomzimba. Lesi yisimo esibi esidinga indlela ehlukahlukene yokwelashwa. Isu elithile lokwelashwa lincike ezicini eziningana, kufaka phakathi uhlobo nesigaba somdlavuza, impilo yesiguli ephelele, kanye nendawo yama-metastases. Ukuxilongwa kusenesikhathi kanye nokwelashwa okufanele kubalulekile ekuthuthukiseni imiphumela.

Izinketho zokwelashwa zeMetastatic NSCLC

Chemotherapy

I-Chemotherapy yindlela evamile yokwelashwa Umdlavuza we-metastatic ongewona omncane weseli, esebenzisa izidakamizwa ukubulala umdlavuza amaseli. Ama-regimens ahlukene we-chemotherapy akhona, futhi ukukhetha kuya ngezinto ezahlukahlukene, njengezempilo ejwayelekile yesiguli kanye nohlobo oluthile lwe-NSCLC. Izidakamizwa ezijwayelekile ze-chemotherapy ezisetshenzisiwe zifaka phakathi i-cisplatin, i-carboplatin, i-paclitaxel, ne-doncetaxel. Imiphumela emibi ingahluka kepha ivame ukufaka isicanucanu, ukukhathala, kanye nokulahleka kwezinwele. Le khasi I-National Cancer Institute Inikeza imininingwane enemininingwane kuma-regimens we-chemotherapy we-NSCLC.

Ukwelashwa okuhlosiwe

Ukwelashwa okuhlosiwe kusebenzisa izidakamizwa eziqondise ngqo amaseli omdlavuza ngokuguqulwa okuthile kofuzo. Lezi zindlela zokwelapha zisebenza ngokukhethekile ezigulini ezine-NSCLC egcina izinguquko ezithile zofuzo, njenge-egfr, alk, i-ros1, noma i-braf. Izibonelo zezidakamizwa zokwelapha ezihlosiwe zifaka i-Osimertinib (Tagrisso), Crizotinib (Xalkori), ne-Afatiinib (GiloTrif). Ngenkathi kusebenza ngempumelelo, izindlela zokwelapha ezihlosiwe nazo zingaholela emiphumeleni emibi, njengokuqhuma kwesikhumba, isifo sohudo, kanye nezinkinga zesibindi. Ukuhlolwa kwezakhi zofuzo kubalulekile ukukhomba iziguli okungenzeka zizuze ekwelashweni okuhlosiwe.

I-ImmunoSatherapy

I-ImmunoSatherapy ihlanganisa amasosha omzimba wokulwa nokulwa namaseli womdlavuza. Lezi zindlela zokwelapha zibaluleke kakhulu ekwelashweni kwe Umdlavuza we-metastatic ongewona omncane weseli. Ukuvimbela ama-incuneice point, njenge-pembrolikumab (Keytruda) kanye ne-nivolumab (OPDIVO), vimba amaprotheni avimbela amasosha omzimba ekuhlaseleni amaseli omdlavuza. Ngenkathi enikeza izimpendulo ezimangazayo kwezinye iziguli, ama-immunotherapy angaba nemiphumela emibi, kufaka phakathi ukukhathala, ukuqhekeka kanye nokuvuvukala. Ukufaneleka kwe-immunotherapy kuncike ezintweni ezifana nenkulumo ye-PD-L1 kanye nesimo esiguquliwe sesimingci.

Ukwelashwa kwemisebe

Ukwelashwa kwemisebe kusebenzisa imisebe ephezulu kakhulu ukubulala umdlavuza amaseli. Ingasetshenziswa ukwelapha ama-metastase enziwe endaweni noma ukunciphisa izimpawu ezibangelwa umdlavuza, njengobuhlungu noma ubunzima bokuphefumula. Izinhlobo ezahlukahlukene zokwelashwa kwemisebe zikhona, kufaka phakathi imisebe yangaphandle yangaphandle kanye ne-brachytherapy. Imiphumela emibi yokwelashwa kwemisebe ingafaka ukucasuka kwesikhumba, ukukhathala, kanye nesicanucanu.

Ukukhetha ukwelashwa kanye nezinto eziguli

Ukukhetha uhlelo lokwelashwa olufanele Umdlavuza we-metastatic ongewona omncane weseli idinga ukuhlolwa okuphelele kwezinto ezimbalwa. Lokhu kufaka phakathi impilo yesiguli, isimo sokusebenza, isigaba nezimpawu zomdlavuza, kanye nokuba khona kwanoma yikuphi ukuguqulwa kofuzo okuthile. Ithimba lama-Oncologinary of Oncologists, ama-radiologists, odokotela abahlinzayo, kanye nabanye ochwepheshe bezokunakekelwa kwempilo bavame ukubambisana ukuthuthukisa uhlelo lokwelashwa oluqondene nomuntu uqobo.

I-Shandong Bandoong BacceCancer Research Institute (https://www.baofahospital.com/) Kunikezelwe ekunikezeni ukunakekelwa komdlavuza okuthuthukile kanye nocwaningo, kusetshenziswa ubuchwepheshe obunqenqemeni kanye nendlela yokubambisana yokuletha imiphumela yeziguli ehlukile. Banikela ngezinsizakalo eziphelele zokuxilonga nezokwelapha ezinhlotsheni ezahlukahlukene zomdlavuza, kufaka phakathi Umdlavuza we-metastatic ongewona omncane weseli.

Ukucwaninga okuqhubekayo nezinkomba ezizayo

Ucwaningo luyaqhubeka ukuqhubekisela phambili ukuqonda nokwelashwa kwe Umdlavuza we-metastatic ongewona omncane weseli. Izindlela ezintsha zokwelapha ezihlosiwe, ama-accunotherapies, kanye nezinhlanganisela zalo zihlale zithuthukiswa futhi zihlolwe ekulingweni kwemitholampilo. Lezi zithuthuka zinikeza ithemba ngemiphumela yokwelashwa ethuthukisiwe kanye nekhwalithi yempilo ethuthukisiwe yeziguli.

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uthole ukuholwa komuntu uqobo mayelana nesimo sakho esithile.