Ukwelashwa kabusha kwe-cell cell carcinoma pathology

Ukwelashwa kwe-Renal Cell Carcinoma: I-pathology ihlu lwe-pathology ye-renal cell carcinoma: I-RCC), uhlobo oluvame kakhulu lomdlavuza wezinso, luveza izici ezihlukile ze-pathological ezithonya amasu okulashwa. Lo mhlahlandlela ubeka izici ezibalulekile ze Ukwelashwa kabusha kwe-cell cell carcinoma pathology, ukusiza ekuhlolweni kokuqonda kanye nokuphathwa. Lolu lwazi lwenzelwe izinjongo zokufundisa futhi alukhangeli izeluleko zezokwelapha. Hlala uthintana nochwepheshe wezokunakekelwa kwempilo kunoma yikuphi ukukhathazeka ngempilo.

Ukuhlukanisa i-Renal Cell Carcinoma

Ama-subtypes omlando

I-RCC ikhombisa ama-subtypes ahlukahlukene omlando, ngalinye linezimpawu ezihlukile ezithinta i-prognosis and ukwelashwa. Okuvame kakhulu yi-Cell RCC (CCRCC), ebonakala ngokucacile kwe-cytoplasm ngenxa yokuqongelelwa kwe-glycogen kanye ne-lipid. Amanye ama-subtypes abalulekile afaka i-papillary RCC (PRCC), i-Chromophobe RCC (Chrcc), kanye nokuqoqa i-DCC RCC (CDRCC). Lawa ma-subtypes ahlukile ekushintsheni kwawo kofuzo, amaphethini okukhula, nezimpendulo zokwelashwa. Ukuhlukaniswa okunembile kubalulekile ukuze kuqondiswe Ukwelashwa kabusha kwe-cell cell carcinoma pathology. Ngemininingwane enemininingwane enemininingwane eminingi kulezi zinto eziphansi, thintana nezinsizakusebenza ze-pathology ezidumile.

Ukulinganisa kanye Nezitayela

Uhlelo lweFuhrman Grading luhlola ibanga lenuzi le-RCC, elibonisa ubutha besimila. Amamaki aphezulu ahambelana nomqondo ompofu. Iziteleka, zisebenzisa uhlelo lwe-TNM (isimila, i-node, i-metastasis), zichaza ubukhulu bokusakazeka kwezimila, okubalulekile ekunqumeni izindlela zokwelashwa. Ukuqonda okuphelele kokubili ukufakwa kanye nokuzila okubalulekile ekuhleleni okusebenzayo kokwelashwa. Isigaba esifanele nebanga lizothonya kakhulu okwakho Ukwelashwa kabusha kwe-cell cell carcinoma pathology.

I-molecular pathology kanye nokwelapha okuhlosiwe

Izinguquko zofuzo

Ukuguqulwa okuthile kwezakhi zofuzo kanye nezinguquko zokushayela i-RCC Development and Progression. I-VHL (von Hippel-Lindau) yofuzo ivame ukubonwa ku-CCRCC, okuholela ekusebenzeni okungama-froxitis of hypoxia-factor (hif) indlela. Ukuqonda laba bashayeli bezakhi zofuzo kusiza ukukhethwa kwezindlela zokwelapha ezihlosiwe. Ukwazi lokhu kwehlukahluka kofuzo kungasiza ukudala okuthize Ukwelashwa kabusha kwe-cell cell carcinoma pathology.

Ukwelashwa okuhlosiwe

Izindlela zokwelapha ezihlosiwe zixhaphaza lobungcweti bezakhi zofuzo, zivimbela izindlela ezithile ze-molefanelar ezibandakanyeka ekukhuleni kwesimila. Izibonelo zifaka phakathi ama-tyrosine kinase inhibitors (TKIS), njenge-sunitinib ne-pazopanib, okuyinto eqondile ye-vascular endotherctor (vegf) receptors. Lezi zindlela zokwelapha zivame ukuba yingxenye yohlelo lokwelashwa olususelwa kokuqondile Ukwelashwa kabusha kwe-cell cell carcinoma pathology kukhonjwe.

Immunohistochemistry (IHC) e-RCC

IHC idlala indima ebalulekile ekuhlolweni nasekuhlosweni kwe-RCC. Amamaki afana ne-CD10 neVenimen kungasiza ukuhlukanisa ama-RCC ​​ama-subtypes. I-IHC nayo isetshenziselwa ukuhlola ama-biomaker angabikezela impendulo ekwelashweni okuhlosiwe.

Ukulingisa Ukuxilongwa kanye nokuqapha ukwelashwa

Amasu wokucabanga afana ne-CT Scans kanye nama-MRI Scans anikezela ngemininingwane ebalulekile mayelana nosayizi we-tumor, indawo, kanye ne-metastasis. Lezi yizinto ezibalulekile ekwakheni okuningiliziwe Ukwelashwa kabusha kwe-cell cell carcinoma pathology. Ukucabanga njalo kusetshenziselwa ukuqapha impendulo yokwelashwa nokuthola ukuphinda kuphinde

Amasu Wokulashwa

Ukukhethwa kokwelashwa kuncike ezicini eziningana, kufaka phakathi isigaba se-tumor, ibanga, kanye nezimpawu zeziguli. Izinketho zibandakanya ukuhlinzwa, ukwelashwa okuhlosiwe, i-immunotherapy, kanye nokwelashwa kwemisebe. Indlela engcono kakhulu inqunywa ngokucatshangelwa ngokucophelela okuqondile Ukwelashwa kabusha kwe-cell cell carcinoma pathology.

Iqhaza LeShandong Baofa Cancer Research Institute

Ukunakekelwa komdlavuza okugcwele, kufaka phakathi amandla okuxilonga athuthukile kanye namasu okuthola ukwelashwa okwenziwe ngezifiso ze-renal cell carcinoma, cabanga ngobuchwepheshe be-Shandong Baafa Cancer cwaninga Institute. Funda kabanzi ngocwaningo lwabo oluthuthukile nokuzibophezela ekunakekelweni okugxile kweziguli ngokuvakashela iwebhusayithi yabo: https://www.baofahospital.com/. Ukugxila kwabo ocwaningweni olunqenqemeni lomkhawulo kunomthelela ngqo ekuthuthukiseni ngcono Ukwelashwa kabusha kwe-cell cell carcinoma pathology.

Ithempeli le-Summary: I-RCC ephakeme

I-subtype	Izici	Ukubikezela kukadokotela ngokuhamba kwesifo
Sula I-Cell RCC	Sula i-cytoplasm, vhl genengactivation	Okuguqukayo, okuvame ukuhlotshaniswa ne-metastasis
I-Papillary RCC	Ukwakhiwa kwe-papillary, kwahlangana nezinguquko	Ngokuvamile kuyathandeka
I-Chromophobe RCC	I-Pale Cytoplasm, isimilo se-morphology	Ngokuvamile kuyathandeka

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nomuntu oqeqeshiwe wezokunakekelwa kwezempilo ukuze kuxilongwa kanye nokwelashwa kwanoma yisiphi isimo sezokwelapha.