Ukwelashwa kokuhlinzekwa kwezidakamizwa okulondoloziwe kwezidakamizwa

Lo mhlahlandlela ophelele uhlola ubunzima be Ukwelashwa okulondolozwe kokwelashwa kwezidakamizwa kokulethwa kwezidakamizwa, Ukuhlola izindlela zako, izinzuzo, izinselelo kanye nezinkomba zesikhathi esizayo. Sisebenzisa izicelo ezahlukahlukene, sicabanga ngezinhlobo ezithile zezidakamizwa kanye neziguli zabantu, zinikeza ukuqonda okucacile kwale ndlela yokwelapha emisha.

Ukuqonda ukulethwa kwezidakamizwa okuqhubekayo

Yini ukwelashwa okulethwa kwezidakamizwa okuqhubekayo?

Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo, eyaziwa nangokuthi ukulethwa kwezidakamizwa okulawulwa okulawulwayo, kuyindlela yezemithi eklanyelwe ukulawula isilinganiso lapho umuthi ukhululwa khona kwifomu lawo lodosi. Ngokungafani nokwakheka kwemali okukhishwe ngokushesha lapho kukhishwa khona umuthi ngokushesha, izinhlelo ezisetshenziselwa ukubekelwa amandla zihlose ukuhlinzeka ngemiphumela yokwelapha engaguquki futhi ende ngaphezulu kwesikhathi esengeziwe. Le ndlela inciphisa ukuguquguquka kwezidakamizwa izidakamizwa, inciphisa imvamisa yokuphatha nokukhulisa ukuhambisana kwesiguli. Izindlela ezithile ezibandakanyekile ziyehluka ngokuya ngokwakha, futhi lezi zinhlelo zingafaka ubuchwepheshe obuhlukahlukene njenge-matrix systems, amasistimu we-reservoir, namaphampu we-osmotic. Umgomo wokugcina ulungiselelwe ukusebenza kwezokwelapha okulungiselelwe ngemiphumela yeziguli ethuthukisiwe.

Izindlela nobuchwepheshe

Izindlela eziningana zisekela ukusebenza kwe Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo. Lokhu kufaka phakathi izinhlelo ezilawulwa ukulawulwa, lapho umuthi uhluka khona nge-polymeric matrix; Izinhlelo ezilawulwa ukuguguleka, lapho i-matrix uqobo iyehla khona ngokuhamba kwesikhathi, ikhipha umuthi; Futhi amasistimu alawulwa yi-Osmotic, asebenzisa ingcindezi ye-osmotic yokulawula ukukhishwa kwezidakamizwa. Ukukhethwa kwendlela kanye nobuchwepheshe kuvame ukuhambisana nezici ezithile zezidakamizwa kanye nephrofayili yokukhishwa oyifunayo.

Izinzuzo kanye nokusetshenziswa kwezidakamizwa okulondolozwe okuqhubekayo

Impumelelo yezokwelapha ethuthukisiwe

Ngokugcina amazinga wezidakamizwa angaguquki, Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo kuvame ukuholela emiphumeleni yokwelapha ethuthukisiwe. Okuncishisiwe ukuguquguquka kunciphise bobabili ubungozi bamazinga ama-subtherapeutic (okuholela ekuhlulekeni kokwelashwa) kanye nokugxila okuphezulu okunobuthi. Lokhu kuzuzisa kakhulu izidakamizwa ezinenkomba yokwelapha emincane.

Ukutholwa okuthuthukile kweziguli

Enye yezinzuzo ezibaluleke kakhulu ukulandelwa kweziguli. Imvamisa encishisiwe ye-dosing ehlotshaniswa nokwakheka kokukhishwa okuqhubekayo kwenza kube lula ezigulini ukuba zithobele amaRegimens abekiwe wemithi. Lokhu kubalulekile ukuthi izimo ezingamahlalakhona zidinga ukwelashwa kwesikhathi eside.

Ukulethwa kwezidakamizwa okuhlosiwe

Yize kungahlali njalo kuzo zonke izinhlelo zokukhipha okuqhubekayo, ezinye izakhiwo ezithuthukile zifaka izindlela zokulethwa eziqondisiwe. Lezi zinhlelo zingaqondisa umuthi kwizicubu ezithile noma izitho ezithile, ngaleyo ndlela zandisa umphumela wokwelapha ngenkathi zinciphisa imiphumela emibi kwezinye izingxenye zomzimba. Le ndawo yocwaningo ivela ngokuqhubekayo, okuholela ezinhlelweni ezintsha.

Izibonelo zezinhlelo zokulethwa kwezidakamizwa ezilondoloziwe

Izidakamizwa eziningi zisebenzisa ubuchwepheshe obukhululiwe. Izibonelo zifaka phakathi kepha azilinganiselwe emithini yenhliziyo (e.g., ezinye izakhi zama-beta-blockers), ama-pain relievers (e.g., ama-analgesics athile we-opioid), kanye nama-antipsychotic. Ukukhethwa kohlelo lokulethwa kuncike ezintweni ezifana nezakhiwo ze-Dischemicochemical, iphrofayili yokukhishwa oyifunayo, kanye nezidingo zomuntu ngamunye.

Izinselelo Nokulinganiselwa

Ukuthuthukiswa Kwemininingwane

Ukuthuthukisa ukwakheka okuzinzile nokuthembekile okumele kube yinselele. Izici ezinjenge-solubity yezidakamizwa, ukuqina, nokusebenzisana okungaba khona ngohlelo lokulethwa ludinga ukucatshangelwa ngokucophelela.

Izindleko nokwenziwa

Izakhi ezisetshenziselwa ukukhishwa zivame ukubandakanya izinqubo zokukhiqiza eziyinkimbinkimbi kunokukhipha maqondana nokukhipha ngokushesha, okuholela ezindlekweni eziphakeme kakhulu.

Ukucatshangelwa Okucacisiwe

Ngenkathi zinenzuzo ngokujwayelekile, izakhiwo ze-Pharmacokinetic ne-Pharmacodynamic zezakhi ezisetshenziselwa ukukhishwa okuqhubekayo zingahluka ngokuya ngezinto ezifuywayo, kufaka phakathi iminyaka, imetabolism, kanye nezinto zokuhlangana. Ukuqapha ngokucophelela kubalulekile.

Izikhombisi zesikhathi esizayo ekwelashweni kokulethwa kwezidakamizwa okuqhubekayo

Ucwaningo luyaqhubeka nokucindezela imingcele ye Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo. Intuthuko nge-nanotechnology, i-biomitadium, namadivayisi angenakufinyeleleka athembisa amasistimu aqondile, ahlosiwe, futhi asebenzayo wokulethwa kwezidakamizwa ngokuzayo. Lokhu kufaka phakathi intuthuko kuma-polymers e-biodermers, amasistimu aphendulayo avuselelayo, kanye nezindlela zomuntu zokwelapha ezenzelwe izidingo zeziguli ngazinye.

Ukuthola eminye imininingwane ngentengo yomdlavuza kanye nezinsizakalo ezihlobene, sicela uvakashele I-Shandong Baafa Cancer Research Institute.