Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza

Le ndatshana ihlinzeka ngesibukezo esibanzi se Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza, ukuhlola izindlela zalo, izinzuzo, izinselelo kanye nezinkomba zesikhathi esizayo. Sisebenzisa ngezindlela ezahlukahlukene, kufaka phakathi i-nanotechnology, ukuhlanganisa izidakamizwa eziphikisana nezidakamizwa, kanye nokwelashwa kwezakhi zofuzo, ukuhlola izinhlelo zabo zokwelashwa kanye nocwaningo oluqhubekayo. Funda ngezinzuzo zokwelashwa okuhlosiwe uma kuqhathaniswa nendabuko ye-chemotherapy kanye nemizamo eqhubekayo yokuthuthukisa ukusebenza kahle nokunciphisa imiphumela emibi.

Izindlela zokulethwa kwezidakamizwa okuhlosiwe

Ukulethwa kwezidakamizwa okususelwa ku-nanotechnology

I-Nanotechnology idlala indima ebalulekile kuyo Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza. Ama-Nanoparticles, ngenxa yobukhulu bawo obuncane kanye nekhono lokungena e-agetgeses, angahambisa ama-chemotherapeapeutic agents ngqo kumaseli ezithuthuthu, anciphise ukuvezwa kwezicubu ezinempilo. Izinhlobo ezahlukahlukene ze-nanoparticles, kufaka phakathi ama-liposomes, ama-nanoparticles we-polymeric, kanye nama-nanoparticles we-inorganic, ahlolisiswa ngamathuba awo okuthuthukisa ukusebenza kwezidakamizwa futhi anciphise ubuthi. Isibonelo, i-liposomal doxorubicin (doxil) iluhlelo lokulethwa kwezidakamizwa okuhlosiwe emtholampilo okunciphisa ama-cardioticity ngokuqhathaniswa ne-doxorubicin ejwayelekile. Ucwaningo luyaqhubeka nokwandisa ukwakhiwa kwe-nanoparticle design for ukuqondiswa kwesigigaba okuthuthukile kanye nezikhumba zokukhishwa kwezidakamizwa. Isikhungo Sokucwaninga Nge-Shandong Baafa Cancer Research sibandakanyeka ekuhlolweni kwentuthuko yakamuva kulo mkhakha.

Izimbotshana zezidakamizwa ze-antibody-Drug (ADCs)

I-ADCS imele elinye isu elibalulekile ngaphakathi Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza. Lawa ma-ejenti wokwelapha aqukethe umuthi we-cytotoxic oxhumene ne-antibon ye-monoclonal ehlose ngqo amaseli omdlavuza. Le ndlela iqinisekisa ukuthi umuthi ulethwa ngokukhethekile kumaseli womdlavuza, ukunciphisa imiphumela ye-off-okuqondiwe kanye nokwenza ngcono inkomba yokwelapha. Izibonelo ze-ADCS ezivunyiwe zifaka iTrastuzumab EMTansine (Kadcyla) yomdlavuza webele we-Her2 - I-Brentuximab Vedotin (Adcetris) yeHodgkin lymphoma. Ucwaningo oluqhubekayo lugxile ekuthuthukiseni ukucaciswa kwe-antibody Target kanye nokwakha amanoveli ama-cytotoxic.

UGene Therapy Usondela

UGene Therapy unikeza i-Avenue Ethembisayo Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza. Le ndlela ifaka ukuguqula izinhlobo zofuzo ngaphakathi kwamaseli womdlavuza ukuze ivimbele ukukhula kwesimila noma ukuthuthukisa amandla amasosha omzimba okulwa nomdlavuza. Ama-viral veectors asetshenziselwa ukuletha ufuzo lokwelapha ukuqondisa amaseli. Okwengeziwe ucwaningo luhlola amasu wokuhlela uGene afana neCrisprPR-CAS9 ngokuguqulwa kwe-gene okuqondile nokusebenza kahle.

Izinzuzo nezinselelo zokulethwa kwezidakamizwa okuhlosiwe

Izinhlelo zokulethwa kwezidakamizwa ezihlosiwe zinikeza izinzuzo eziningana ngaphezulu kwe-chemotherapy evamile, kufaka phakathi ukusebenza ngempumelelo, ubuthi obuncishisiwe, nokubekezelela iziguli. Kodwa-ke, izinselelo zikhona, okubandakanya ukuthuthukiswa kokumelana nezidakamizwa, isidingo sokwelashwa okuthuthukile kwesigigaba, kanye nezindleko eziphakeme zalezi zindlela zokwelapha.

Ithebula 1: Ukuqhathaniswa kwezindlela ezihlosiwe zokulethwa kwezidakamizwa

Izikhombisi zekusasa ekulethweni kwezidakamizwa okuhlosiwe komdlavuza

Ucwaningo oluqhubekayo lugxile ekubhekaneni nemikhawulo yezinhlelo zamanje ezihlosiwe kwezidakamizwa kanye nezindlela zokwakha amanoveli. Lokhu kufaka phakathi ukuthuthukisa ukucaciswa kokuqondisa izidakamizwa, ukuthuthukisa ama-kinetics okukhululwa kwezidakamizwa, nokunqoba ukumelana nezidakamizwa. Ukuhlanganiswa kwamasu wokuqondisa okuhlosiwe, izindlela ezenzelwe wena zemithi, kanye nokuthuthukiswa kwezinhlelo ezihlakaniphile zokulethwa kwezidakamizwa kulindeleke ukuthi zithuthukise ukusebenza kahle nokuphepha kwe Ukwelashwa okubhekiswe ekulethweni kwezidakamizwa komdlavuza. Ucwaningo olwengeziwe ezikhungweni ezinjenge I-Shandong Baafa Cancer Research Institute kubalulekile ekuthuthukiseni le nkambu.

Ukuzikhulula: Lolu lwazi lwenzelwe izinjongo zokufundisa kuphela futhi akufanele lubhekwe njengeluleke lwezokwelapha. Hlala uthintana nochwepheshe wezokunakekelwa kwempilo kunoma yikuphi ukukhathazeka ngempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo yakho noma yokwelashwa.

Izinkomba: (Faka phakathi izingcaphuno ezifanele lapha, ukubhekisisa izifundo ezithile nezincwadi ezisekela imininingwane eyethulwe. Sebenzisa isitayela sokucaphuna esingaguquki.)